Gut-liver indole metabolism (WP3627)

Dietary tryptophane is metabolised by the gut microbiome to indole and IPA which reaches the human blood system. Indole is further metabolized into indoxyl sulfate which also reached the blood.
last edited

Authors

Egonw, Khanspers, Mkutmon, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: classic metabolic pathway

Participants

Label Type Compact Identifier
indoxyl Metabolite chebi:17840
IPA Metabolite chebi:43580
tryptophanase GeneProduct eccode:4.1.99.1
sulfotransferase GeneProduct None
indole Metabolite chebi:16881
dietarytryptophan Metabolite chebi:27897
CYP2E1 GeneProduct ensembl:ENSG00000130649
indole Metabolite chebi:16881
indole Metabolite chebi:16881
IPA Metabolite chebi:43580
indoxyl sulfate Metabolite chebi:43355
indoxyl sulfate Metabolite chebi:43355

References

  1. Wikoff WR, Anfora AT, Liu J, Schultz PG, Lesley SA, Peters EC, et al. Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3698–703. PubMed Europe PMC Scholia