Lung fibrosis (WP3632)

(Nanoparticle) induced lung fibrosis pathway. Note! Mouse homologues for SERPINA1 and SFTPA2 are missing and the pathway currently contains the human equivalents. Other users are encouraged to add this information when available.
last edited

Authors

Fehrhart, Khanspers, MaintBot, Penny, Mkutmon, Jmelius, Egonw, and Laurent

Cited In

Organism

Mus musculus

Communities

Adverse Outcome Pathways

Annotations

Disease Ontology: pulmonary fibrosis

Pathway Ontology: respiratory system disease pathway

Participants

Label Type Compact Identifier
Cytokinesand inflammatoryresponse Pathway wikipathways:WP222
TGF betasignaling Pathway wikipathways:WP258
NRF2signaling Pathway wikipathways:WP2884
Toll-like receptorsignaling Pathway wikipathways:WP1271
Matrixmetalloproteinases Pathway wikipathways:WP441
DifferentiationPathway Pathway wikipathways:WP2848
Apoptosis Pathway wikipathways:WP1254
Rtel1 GeneProduct ensembl:ENSMUSG00000038685
Cxcl2 GeneProduct ensembl:ENSMUSG00000058427
Spp1 GeneProduct ensembl:ENSMUSG00000029304
Dpp9 GeneProduct ensembl:ENSMUSG00000001229
Fgf1 GeneProduct ensembl:ENSMUSG00000036585
Ccl4 GeneProduct ensembl:ENSMUSG00000018930
Smad7 GeneProduct ensembl:ENSMUSG00000025880
Terc GeneProduct ensembl:ENSMUSG00000064796
Ctgf GeneProduct ensembl:ENSMUSG00000019997
SFTPA2 GeneProduct ensembl:ENSG00000185303
Parn GeneProduct ensembl:ENSMUSG00000022685
MAPKsignaling Pathway wikipathways:WP493
Ccl2 GeneProduct ensembl:ENSMUSG00000035385
SERPINA1 GeneProduct ensembl:ENSG00000197249
Skil GeneProduct ensembl:ENSMUSG00000027660
Tnf GeneProduct ensembl:ENSMUSG00000024401
Sftpa1 GeneProduct ensembl:ENSMUSG00000021789
Il6 GeneProduct ensembl:ENSMUSG00000025746
Oxidative Stress Pathway wikipathways:WP412
Edn1 GeneProduct ensembl:ENSMUSG00000021367
Eln GeneProduct ensembl:ENSMUSG00000029675
Csf3 GeneProduct ensembl:ENSMUSG00000038067
Grem1 GeneProduct ensembl:ENSMUSG00000074934
Inflammasomeactivation Pathway wikipathways:WP1256
Dsp GeneProduct ensembl:ENSMUSG00000054889
Tert GeneProduct ensembl:ENSMUSG00000021611
Mecp2 GeneProduct ensembl:ENSMUSG00000031393
Cxcl15 GeneProduct ensembl:ENSMUSG00000029375
Obfc1 GeneProduct ensembl:ENSMUSG00000042694
Calca GeneProduct ensembl:ENSMUSG00000030669
Tgfa GeneProduct ensembl:ENSMUSG00000029999
Il13 GeneProduct ensembl:ENSMUSG00000020383
Il1b GeneProduct ensembl:ENSMUSG00000027398
Ccr3 GeneProduct ensembl:ENSMUSG00000035448
Ccl5 GeneProduct ensembl:ENSMUSG00000035042
Pdgfa GeneProduct ensembl:ENSMUSG00000025856
NADPHoxidase Pathway wikipathways:WP3396
Ccl11 GeneProduct ensembl:ENSMUSG00000020676
Atp11a GeneProduct ensembl:ENSMUSG00000031441
Fgf2 GeneProduct ensembl:ENSMUSG00000037225
Inflammation Pathway wikipathways:WP458
Cma1 GeneProduct ensembl:ENSMUSG00000022225
Il5 GeneProduct ensembl:ENSMUSG00000036117
Coagulation disturbances Pathway wikipathways:WP449
Egf GeneProduct ensembl:ENSMUSG00000028017
Timp1 GeneProduct ensembl:ENSMUSG00000001131
NF-KB Pathway kegg.pathway:mmu04064
Il12b GeneProduct ensembl:ENSMUSG00000004296
Bmp7 GeneProduct ensembl:ENSMUSG00000008999
Pdgfb GeneProduct ensembl:ENSMUSG00000000489
Ptx3 GeneProduct ensembl:ENSMUSG00000027832
Nfe2l2 GeneProduct ensembl:ENSMUSG00000015839
Mmp9 GeneProduct ensembl:ENSMUSG00000017737
Fgf7 GeneProduct ensembl:ENSMUSG00000027208
Muc5b GeneProduct ensembl:ENSMUSG00000066108
Cebpb GeneProduct ensembl:ENSMUSG00000056501
Cysltr2 GeneProduct ensembl:ENSMUSG00000033470
Hmox1 GeneProduct ensembl:ENSMUSG00000005413
p38 MAPK Pathway wikipathways:WP350
Mmp2 GeneProduct ensembl:ENSMUSG00000031740
Hgf GeneProduct ensembl:ENSMUSG00000028864
Sftpc GeneProduct ensembl:ENSMUSG00000022097
Ccr2 GeneProduct ensembl:ENSMUSG00000049103
Il4 GeneProduct ensembl:ENSMUSG00000000869
Csf2 GeneProduct ensembl:ENSMUSG00000018916
Elmod2 GeneProduct ensembl:ENSMUSG00000035151
Plau GeneProduct ensembl:ENSMUSG00000021822
Fam13a GeneProduct ensembl:ENSMUSG00000037709
Ccl3 GeneProduct ensembl:ENSMUSG00000000982
Mt2 GeneProduct ensembl:ENSMUSG00000031762
Igf1 GeneProduct ensembl:ENSMUSG00000020053
Tgfb1 GeneProduct ensembl:ENSMUSG00000002603
NF-KB Pathway kegg.pathway:mmu04064
Inflammasomeactivation Pathway wikipathways:WP1256
Chondrocytedifferentiation Pathway wikipathways:WP1270
Stressfibre assembly Pathway wikipathways:WP2666
Collagen producton Pathway wikipathways:WP2798

References

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  2. Naumanen P, Lappalainen P, Hotulainen P. Mechanisms of actin stress fibre assembly. J Microsc. 2008 Sep;231(3):446–54. PubMed Europe PMC Scholia
  3. Todd NW, Luzina IG, Atamas SP. Molecular and cellular mechanisms of pulmonary fibrosis. Fibrogenesis Tissue Repair. 2012 Jul 23;5(1):11. PubMed Europe PMC Scholia
  4. Montojo J, Zuberi K, Rodriguez H, Bader GD, Morris Q. GeneMANIA: Fast gene network construction and function prediction for Cytoscape. F1000Res. 2014 Jul 1;3:153. PubMed Europe PMC Scholia
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  6. Vietti G, Lison D, van den Brule S. Mechanisms of lung fibrosis induced by carbon nanotubes: towards an Adverse Outcome Pathway (AOP). Part Fibre Toxicol. 2016 Feb 29;13:11. PubMed Europe PMC Scholia
  7. Labib S, Williams A, Yauk CL, Nikota JK, Wallin H, Vogel U, et al. Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes. Part Fibre Toxicol. 2016 Mar 15;13:15. PubMed Europe PMC Scholia
  8. Nymark P, Rieswijk L, Ehrhart F, Jeliazkova N, Tsiliki G, Sarimveis H, et al. A Data Fusion Pipeline for Generating and Enriching Adverse Outcome Pathway Descriptions. Toxicol Sci. 2018 Mar 1;162(1):264–75. PubMed Europe PMC Scholia