Insulin signaling in adipocytes (diabetic condition) (WP3635)

The paper describes insulin signaling in human adipocytes under normal and diabetic states using mathematical models based on experimental data. This model corresponds to insulin signaling under diabetic condition. Insulin signaling under normal condition is represented in WP3634. The model has been converted to GPML using the PathSBML plugin from PathVisio, importing the model BIOMD0000000449 from the BioModels Database directly. The layout has been improved manually.
last edited


Anwesha, Khanspers, AMTan, Egonw, and Eweitz

Cited In


Homo sapiens



Disease Ontology: diabetes mellitus

Pathway Ontology: insulin signaling pathway

Cell Type Ontology: fat cell


Label Type Compact Identifier
AS160 Protein uniprot:O60343
AS160p GeneProduct NA:PATO:0002220
GLUT4 Protein uniprot:P14672
GLUT4m Protein uniprot:P14672
IR Protein uniprot:P06213
IRS1 Protein uniprot:P35568
IRS1307 Protein uniprot:P35568
IRS1p Protein uniprot:P35568
IRS1p307 Protein uniprot:P35568
IRi Protein uniprot:P06213
IRins Protein uniprot:P06213
IRip Protein uniprot:P06213
IRp Protein uniprot:P06213
PKB Protein uniprot:P31751
PKB308p Protein uniprot:P31751
PKB308p473p Protein uniprot:P31751
PKB473p Protein uniprot:P31751
S6 Protein uniprot:P62753
S6K Protein uniprot:P23443
S6Kp Protein uniprot:P23443
S6p Protein uniprot:P62753
X Metabolite chebi:36080
Xp Metabolite kegg.compound:C00562
mTORC1 Protein uniprot:P42345
mTORC1a Protein uniprot:P42345
mTORC2 Protein uniprot:P42345
mTORC2a Protein uniprot:P42345


  1. Brännmark C, Nyman E, Fagerholm S, Bergenholm L, Ekstrand E-M, Cedersund G, et al. Insulin signaling in type 2 diabetes: experimental and modeling analyses reveal mechanisms of insulin resistance in human adipocytes. J Biol Chem. 2013 Apr 5;288(14):9867–80. PubMed Europe PMC Scholia