Hepatitis C and hepatocellular carcinoma (WP3646)

Pathway model based on hub miRNAs and their putative targets from network analysis. * From a set of differentially expressed genes in both chronic HCV (hepatitis C virus) and HCC (hepatocellular carcinoma) samples, a protein-protein network was constructed using STRING (http://string-db.org/) and GeneMANIA (http://genemania.org/). * After topological analysis and network visualization in Cytoscape, the top hub genes were identified. * miRNAs related to hub genes were identified using miRTarBase server and combined with the PPI network to constructed a miRNA-Hubgene network. Based on Figure 4 from Poortahmasebi et al, How Hepatitis C Virus Leads to Hepatocellular Carcinoma: A Network-Based Study. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3646 CPTAC Assay Portal]
last edited

Authors

Khanspers, Jmelius, AMTan, Mkutmon, Egonw, and Eweitz

Cited In

Organism

Homo sapiens

Communities

CPTAC Diseases

Annotations

Disease Ontology: hepatocellular carcinoma

Pathway Ontology: disease pathway

Participants

Label Type Compact Identifier
BIRC3 GeneProduct ensembl:ENSG00000023445
MAPK14 GeneProduct ensembl:ENSG00000112062
Angiogenesis Pathway wikipathways:WP1539
RRM2 GeneProduct ensembl:ENSG00000171848
VEGFA GeneProduct ensembl:ENSG00000112715
FASLG GeneProduct ensembl:ENSG00000117560
WNT Signaling Pathway wikipathways:WP428
COL4A2 GeneProduct ensembl:ENSG00000134871
RAC1 GeneProduct ensembl:ENSG00000136238
BCL2L1 GeneProduct ensembl:ENSG00000171552
CXCR1 GeneProduct ensembl:ENSG00000163464
BIRC5 GeneProduct ensembl:ENSG00000089685
PI3K Signaling Pathway None
MIR34A GeneProduct ensembl:ENSG00000284357
VAV2 GeneProduct ensembl:ENSG00000160293
STAT3 GeneProduct ensembl:ENSG00000168610
PODXL GeneProduct ensembl:ENSG00000128567
PTPN11 GeneProduct ensembl:ENSG00000179295
UCHL1 GeneProduct ensembl:ENSG00000154277
MAPK3 GeneProduct ensembl:ENSG00000102882
CCND1 GeneProduct ensembl:ENSG00000110092
VEGFA GeneProduct ensembl:ENSG00000112715
FRZB GeneProduct ensembl:ENSG00000162998
Cell Cycle Progression Pathway wikipathways:WP45
NFKB1 Signaling Pathway None
Cell Proliferation Pathway None
TP53 GeneProduct ensembl:ENSG00000141510
JAK1 GeneProduct ensembl:ENSG00000162434
IL8 GeneProduct ensembl:ENSG00000169429
MMP1 GeneProduct ensembl:ENSG00000196611
MAPK Signaling Pathway wikipathways:WP382
MIR744 GeneProduct ensembl:ENSG00000266297
NFKB1 GeneProduct ensembl:ENSG00000109320
AKT1 GeneProduct ensembl:ENSG00000142208
DNA Repair Pathway wikipathways:WP707
MYOF GeneProduct ensembl:ENSG00000138119
IL6R GeneProduct ensembl:ENSG00000160712
LEF1 GeneProduct ensembl:ENSG00000138795
BRCA1 GeneProduct ensembl:ENSG00000012048
CD44 GeneProduct ensembl:ENSG00000026508
IL6 GeneProduct ensembl:ENSG00000136244
SOS1 GeneProduct ensembl:ENSG00000115904
CASP9 GeneProduct ensembl:ENSG00000132906
CCND1 GeneProduct ensembl:ENSG00000110092
TGFB1 GeneProduct ensembl:ENSG00000105329
CTTN GeneProduct ensembl:ENSG00000085733
Cytoskeleton Activation Pathway None
Cell Migration Pathway None
Apoptosis Pathway wikipathways:WP254
SMAD3 GeneProduct ensembl:ENSG00000166949
PTGS2 GeneProduct ensembl:ENSG00000073756
E2F2 GeneProduct ensembl:ENSG00000007968
GRB2 GeneProduct ensembl:ENSG00000177885
HIF1A GeneProduct ensembl:ENSG00000100644
MYC GeneProduct ensembl:ENSG00000136997
CASP3 GeneProduct ensembl:ENSG00000164305
CDKN1A GeneProduct ensembl:ENSG00000124762
HNF1A GeneProduct ensembl:ENSG00000135100
MYC GeneProduct ensembl:ENSG00000136997
JUN GeneProduct ensembl:ENSG00000177606
CCND1 GeneProduct ensembl:ENSG00000110092
MYC GeneProduct ensembl:ENSG00000136997
MAPK Signaling Pathway wikipathways:WP382
MYC GeneProduct ensembl:ENSG00000136997
Cell Proliferation Pathway None
Cell Proliferation Pathway None
Angiogenesis Pathway wikipathways:WP1539
Apoptosis Pathway wikipathways:WP254
CASP9 GeneProduct ensembl:ENSG00000132906
CASP7 GeneProduct ensembl:ENSG00000165806
MIR34A GeneProduct ensembl:ENSG00000284357
MIR155 GeneProduct ensembl:ENSG00000283904
MIR34A GeneProduct ensembl:ENSG00000284357
MIR155 GeneProduct ensembl:ENSG00000283904
MIR34A GeneProduct ensembl:ENSG00000284357
MIR155 GeneProduct ensembl:ENSG00000283904
MIR24-1 GeneProduct ensembl:ENSG00000284459
MIR24-2 GeneProduct ensembl:ENSG00000284387
MIR92A1 GeneProduct hgnc.symbol:MIR92A1
MIR92A2 GeneProduct ensembl:ENSG00000284538
BIRC3 GeneProduct ensembl:ENSG00000023445
BCL2L1 GeneProduct ensembl:ENSG00000171552
Apoptosis Pathway wikipathways:WP254
NOS2 GeneProduct ensembl:ENSG00000007171
Angiogenesis Pathway wikipathways:WP1539
MIR34A GeneProduct ensembl:ENSG00000284357
MAPK Signaling Pathway wikipathways:WP382
MAPK8 GeneProduct ensembl:ENSG00000107643
JUN GeneProduct ensembl:ENSG00000177606
CCND1 GeneProduct ensembl:ENSG00000110092
IL8 GeneProduct ensembl:ENSG00000169429
MMP1 GeneProduct ensembl:ENSG00000196611
SMAD4 GeneProduct ensembl:ENSG00000141646
CDKN1A GeneProduct ensembl:ENSG00000124762
TGFBR1 GeneProduct ensembl:ENSG00000106799
MIR24-1 GeneProduct ensembl:ENSG00000284459
MIR24-2 GeneProduct ensembl:ENSG00000284387
MIR744 GeneProduct ensembl:ENSG00000266297
MAPK Signaling Pathway wikipathways:WP382
Apoptosis Pathway wikipathways:WP254
MIR155 GeneProduct ensembl:ENSG00000283904
Angiogenesis Pathway wikipathways:WP1539
TNFSS10 GeneProduct ensembl:ENSG00000117560
Cell Proliferation Pathway None
Cell Proliferation Pathway None

References

  1. Poortahmasebi V, Poorebrahim M, Najafi S, Jazayeri SM, Alavian SM, Arab SS, et al. How Hepatitis C Virus Leads to Hepatocellular Carcinoma: A Network-Based Study. Hepat Mon. 2016 Feb 20;16(2):e36005. PubMed Europe PMC Scholia