Wnt myofibroblastic activation of hepatic stellate cells (WP3649)

This pathway is modeled after figure 5 from Kweon et al. The WNT signaling pathway activates Beta-catenin which inhibits serine and cysteine proteases. This inhibition of these proteins increases MeCP2 stability and induces epigenetic repression of Ppar-y leading to hepatic stellate cell myofibroblastic activation causing liver fibrosis which can lead to liver cirrhosis.
last edited

Authors

AAR&Co, Egonw, MirellaKalafati, Khanspers, and Eweitz

Cited In

Organism

Rattus norvegicus

Communities

Annotations

Pathway Ontology: signaling pathway

Cell Type Ontology: hepatic stellate cell

Disease Ontology: liver cirrhosis

Participants

Label Type Compact Identifier
Leupeptin Metabolite pubchem.compound:72429
Ser/Cys Peptidases Protein None
Ppar-y Protein ensembl:ENSRNOG00000008839
Wnt-3a Protein ensembl:ENSRNOT00000064505
FJ9 Metabolite None
DPI Metabolite pubchem.compound:3101
MeCP2 Protein ensembl:ENSRNOG00000056659
Beta-Catenin GeneProduct ncbigene:84353

References

  1. Kweon S-M, Chi F, Higashiyama R, Lai K, Tsukamoto H. Wnt Pathway Stabilizes MeCP2 Protein to Repress PPAR-γ in Activation of Hepatic Stellate Cells. PLoS One. 2016 May 23;11(5):e0156111. PubMed Europe PMC Scholia