Interleukin-1 induced activation of NF-kB (WP3656)

Interleukin-1 Induced activation of NF-kB through the phosphorylated TRAF6/Ajuba/PKCz/SQST1 complex. The pathway is defined by multiple binding steps to the TRAF6/Ajuba/PKCz/SQST1 complex. The small arrows constitute a earlier binding. After binding occurs the complex is phosphorylated and activates NF-kB. This pathway is based on figure 6 from Li et al.
last edited

Authors

AAR&Co, Jmelius, Khanspers, Egonw, MaintBot, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: signaling pathway

Participants

Label Type Compact Identifier
AJUBA GeneProduct ensembl:ENSG00000129474
PKCZ GeneProduct ensembl:ENSG00000067606
PKCZ GeneProduct ensembl:ENSG00000067606
IL-1 GeneProduct ensembl:ENSG00000115008
SQSTM1 GeneProduct ensembl:ENSG00000161011
ATP Metabolite hmdb:HMDB0000538
NF-KB GeneProduct uniprot:P19838
TRAF6 GeneProduct ensembl:ENSG00000175104
AJUBA GeneProduct ensembl:ENSG00000129474
TIFA GeneProduct ensembl:ENSG00000145365
SQSTM1 GeneProduct ensembl:ENSG00000161011
UEV1A GeneProduct ensembl:ENSG00000244687
TIFA GeneProduct ensembl:ENSG00000145365
UBC13 GeneProduct ensembl:ENSG00000177889
UEV1A GeneProduct ensembl:ENSG00000244687
ADP Metabolite hmdb:HMDB0001341
PKCZ GeneProduct ensembl:ENSG00000067606
UBC13 GeneProduct ensembl:ENSG00000177889
SQSTM1 GeneProduct ensembl:ENSG00000161011
TRAF6 GeneProduct ensembl:ENSG00000175104
IRAK1 GeneProduct ensembl:ENSG00000184216
IRAK1 GeneProduct ensembl:ENSG00000184216
AJUBA GeneProduct ensembl:ENSG00000129474
PKCZ GeneProduct ensembl:ENSG00000067606
TIFA GeneProduct ensembl:ENSG00000145365
SQSTM1 GeneProduct ensembl:ENSG00000161011
UBC13 GeneProduct ensembl:ENSG00000177889
UEV1A GeneProduct ensembl:ENSG00000244687
TRAF6 GeneProduct ensembl:ENSG00000175104
IRAK1 GeneProduct ensembl:ENSG00000184216

References

  1. Li F, Thiele I, Jamshidi N, Palsson BØ. Identification of potential pathway mediation targets in Toll-like receptor signaling. PLoS Comput Biol. 2009 Feb;5(2):e1000292. PubMed Europe PMC Scholia