Hematopoietic stem cell gene regulation by GABP alpha/beta complex (WP3657)

GABP alpha/beta complex mediates the maintenance of hematopoietic stem cells (HSCs) through control of proteins necessary for epigenetic modification and transcription regulation. The activation of key transcription factors and proteins required for HSC survival, self renewal, quiescence, differentiation, and aging is controlled by the GABP alpha/beta complex. This complex also down-regulates GZMB, protein important for inhibiting HSC survival. This pathway is based on figure 7 from Yu et al. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3657 CPTAC Assay Portal]
last edited

Authors

AAR&Co, Egonw, Fehrhart, Khanspers, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: DNA modification pathway

Cell Type Ontology: hematopoietic stem cell

Participants

Label Type Compact Identifier
SMARCA4 GeneProduct ensembl:ENSG00000127616
HSC self renewal Pathway kegg.pathway:map04550
BCL2 GeneProduct ensembl:ENSG00000171791
HSC differentiation Pathway wikipathways:WP2849
DNMT3B GeneProduct ensembl:ENSG00000088305
DNMT3A GeneProduct ensembl:ENSG00000119772
TERF2 GeneProduct ensembl:ENSG00000132604
ETV6 GeneProduct ensembl:ENSG00000139083
DNMT1 GeneProduct ensembl:ENSG00000130816
ZFX GeneProduct ensembl:ENSG00000005889
GZMB GeneProduct ensembl:ENSG00000100453
HSC aging Pathway kegg.pathway:map04213
SMAD4 GeneProduct ensembl:ENSG00000141646
GABPA GeneProduct ensembl:ENSG00000154727
PTEN GeneProduct ensembl:ENSG00000171862
BCL2L1 GeneProduct ensembl:ENSG00000171552
FOXO3 GeneProduct ensembl:ENSG00000118689
GABPB GeneProduct ensembl:ENSG00000104064
FLT3 GeneProduct ensembl:ENSG00000122025
CREBBP GeneProduct ensembl:ENSG00000005339
EP300 GeneProduct ensembl:ENSG00000100393
Chromatin remodeling and epigenetic modifications Pathway wikipathways:WP3362
HSC survival Pathway kegg.pathway:map04210
ATM GeneProduct ensembl:ENSG00000149311
HSC quiescence Pathway None
MCL1 GeneProduct ensembl:ENSG00000143384

References

  1. Yu S, Cui K, Jothi R, Zhao D-M, Jing X, Zhao K, et al. GABP controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells. Blood. 2011 Feb 17;117(7):2166–78. PubMed Europe PMC Scholia