Wnt/beta-catenin signaling pathway in leukemia (WP3658)

The Wnt/Beta-catenin pathway mediates the transcription of proteins important for maintenance and growth of hematopoietic stem cells. The inhibition of Wnt leads to protein degradation through Beta-Catenin activation by the Axin/APC/CK1/GSK3B protein complex. This pathway is based on figure 5 from Misaghian et al. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3658 CPTAC Assay Portal]
last edited

Authors

AAR&Co , Linda Rieswijk , Kristina Hanspers , Mick Eikelhof , Andika Tan , Maintenance bot , and Eric Weitz

Cited In

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Organism

Homo sapiens

Communities

CPTAC Diseases

Annotations

Disease Ontology: leukemia

Pathway Ontology: altered Wnt signaling pathway

Participants

Label Type Compact Identifier
Phosphate Metabolite hmdb:HMDB0001429
Phosphate Metabolite hmdb:HMDB0001429
DKK GeneProduct ensembl:ENSG00000107984
c-MYC GeneProduct ensembl:ENSG00000136997
AML1 GeneProduct ensembl:LRG_482
TCF GeneProduct ensembl:ENSG00000071564
LEF GeneProduct ensembl:ENSG00000138795
PPARD GeneProduct ensembl:ENSG00000112033
GSK3B GeneProduct ensembl:ENSG00000082701
WNT GeneProduct ensembl:ENSG00000125084
RARA GeneProduct ensembl:ENSG00000131759
PLZF GeneProduct ensembl:ENSG00000109906
BCL9 GeneProduct ensembl:ENSG00000116128
RUNX1T1 GeneProduct ensembl:ENSG00000079102
FLT3 GeneProduct ensembl:ENSG00000122025
PML GeneProduct ensembl:ENSG00000140464
AKT GeneProduct ensembl:ENSG00000142208
RARA GeneProduct ensembl:ENSG00000131759
LRP6 GeneProduct ensembl:ENSG00000070018
APC GeneProduct ensembl:ENSG00000134982
CK1 GeneProduct ensembl:ENSG00000113712
LRP5 GeneProduct ensembl:ENSG00000162337
WIF1 GeneProduct ensembl:ENSG00000156076
AXIN GeneProduct ensembl:ENSG00000168646
SALL4 GeneProduct ensembl:ENSG00000101115
PYGO GeneProduct ensembl:ENSG00000171016
Junction plakoglobin Protein uniprot:P14923
Frizzled Protein uniprot:E5RGK8
cyclin-D1 Protein uniprot:P24385
Catenin beta-1 Protein uniprot:B4DGU4
Catenin beta-1 Protein uniprot:B4DGU4

References

  1. Misaghian N, Ligresti G, Steelman LS, Bertrand FE, Bäsecke J, Libra M, et al. Targeting the leukemic stem cell: the Holy Grail of leukemia therapy. Leukemia. 2009 Jan;23(1):25–42. PubMed Europe PMC Scholia