IL-3 signaling pathway (WP373)

Interleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common beta chain, which is shared between all members of this cytokine family. Binding of IL-3 to IL3RA recruits the beta chain to the complex, which activates the JAK/STAT, MAPK and PI 3-kinase signaling modules. Source: NetPath
last edited


A.Pandey, MaintBot, Christine Chichester, and Eweitz

Cited In


Mus musculus



Pathway Ontology: interleukin-3 signaling pathway


Label Type Compact Identifier
IL3 GeneProduct ncbigene:16187
Stat1 GeneProduct ncbigene:20846
Raf1 GeneProduct ncbigene:110157
Stat5a GeneProduct ncbigene:20850
Fcer2a GeneProduct ncbigene:14128
Slc2a1 GeneProduct ncbigene:20525
Kcnip3 GeneProduct ncbigene:56461
Cbl GeneProduct ncbigene:12402
Ptpn6 GeneProduct ncbigene:15170
Atf2 GeneProduct ncbigene:11909
Shc1 GeneProduct ncbigene:20416
Mapk7 GeneProduct ncbigene:23939
Jak2 GeneProduct ncbigene:16452
Pxn GeneProduct ncbigene:19303
Ywhaz GeneProduct ncbigene:22631
Vcl GeneProduct ncbigene:22330
Stat6 GeneProduct ncbigene:20852
Gab1 GeneProduct ncbigene:14388
Tec GeneProduct ncbigene:21682
Tyk2 GeneProduct ncbigene:54721
Matk GeneProduct ncbigene:17179
Mapk1 GeneProduct ncbigene:26413
Ptk2 GeneProduct ncbigene:14083
Pik3cd GeneProduct ncbigene:18707
Gata2 GeneProduct ncbigene:14461
Pik3r1 GeneProduct ncbigene:18708
Lyn GeneProduct ncbigene:17096
Bad GeneProduct ncbigene:12015
Bcl2l11 GeneProduct ncbigene:12125
Grb2 GeneProduct ncbigene:14784
CSF2RB GeneProduct ncbigene:12983
Sos1 GeneProduct ncbigene:20662
Slc2a1 GeneProduct ncbigene:20525
ATF1 GeneProduct ncbigene:11908
Vav1 GeneProduct ncbigene:22324
Chek1 GeneProduct ncbigene:12649
Crk GeneProduct ncbigene:12928
Jak1 GeneProduct ncbigene:16451
Stat3 GeneProduct ncbigene:20848
Prkca GeneProduct ncbigene:18750
Id1 GeneProduct ncbigene:15901
PILRB GeneProduct None
Gnb2l1 GeneProduct ncbigene:14694
IL3 GeneProduct ncbigene:16187
Mapk8 GeneProduct ncbigene:26419
Gab2 GeneProduct ncbigene:14389
Stat5b GeneProduct ncbigene:20851
Prkaca GeneProduct ncbigene:18747
Bmx GeneProduct ncbigene:12169
CSF2RB GeneProduct ncbigene:12983
Lck GeneProduct ncbigene:16818
Ywhab GeneProduct ncbigene:54401
Mapk3 GeneProduct ncbigene:26417
Gm2423 GeneProduct ncbigene:100039786
Dnm1 GeneProduct ncbigene:13429
Birc5 GeneProduct ncbigene:11799
Mapk14 GeneProduct ncbigene:26416
Il3ra GeneProduct ncbigene:16188
Ppp2ca GeneProduct ncbigene:19052
Akt1 GeneProduct ncbigene:11651
Gene Symbol GeneProduct None
Nfkb1 GeneProduct ncbigene:18033
Rps6kb2 GeneProduct ncbigene:58988
Gsk3b GeneProduct ncbigene:56637
Tnfrsf1b GeneProduct ncbigene:21938
Bcl2 GeneProduct ncbigene:12043
Sfpi1 GeneProduct ncbigene:20375
Prkcb GeneProduct ncbigene:18751
Gata1 GeneProduct ncbigene:14460
Mras GeneProduct ncbigene:17532
Kras GeneProduct ncbigene:16653
Bad GeneProduct ncbigene:12015
Mmp9 GeneProduct ncbigene:17395
Ptpn11 GeneProduct ncbigene:19247
Creb1 GeneProduct ncbigene:12912
Rap1a GeneProduct ncbigene:109905
Rara GeneProduct ncbigene:19401
Shc1 GeneProduct ncbigene:20416
Mapk3 GeneProduct ncbigene:26417
Syk GeneProduct ncbigene:20963
Src GeneProduct ncbigene:20779
Pik3ca GeneProduct ncbigene:18706
Bax GeneProduct ncbigene:12028
Mapkapk2 GeneProduct ncbigene:17164
Cish GeneProduct ncbigene:12700
Pik3r2 GeneProduct ncbigene:18709
Mapk9 GeneProduct ncbigene:26420
IL3 GeneProduct ncbigene:16187
Hspb1 GeneProduct ncbigene:15507
Inpp5d GeneProduct ncbigene:16331
Crkl GeneProduct ncbigene:12929
Fes GeneProduct ncbigene:14159
Hras1 GeneProduct ncbigene:15461
Rac2 GeneProduct ncbigene:19354
Rapgef1 GeneProduct ncbigene:107746
Selp GeneProduct ncbigene:20344
Gsk3a GeneProduct ncbigene:606496
Foxo1 GeneProduct ncbigene:56458
Prkca GeneProduct ncbigene:18750
Pak1 GeneProduct ncbigene:18479
Il3ra GeneProduct ncbigene:16188
SOCS2 GeneProduct ncbigene:216233
Rxra GeneProduct ncbigene:20181
IL3 GeneProduct ncbigene:16187
Map2k1 GeneProduct ncbigene:26395
Hck GeneProduct ncbigene:15162
Nfkb1 GeneProduct ncbigene:18033
Mmp2 GeneProduct ncbigene:17390
Socs3 GeneProduct ncbigene:12702
Rac1 GeneProduct ncbigene:19353
Bcl2l1 GeneProduct ncbigene:12048
CDC42 GeneProduct ncbigene:12540
Fyn GeneProduct ncbigene:14360