Wnt signaling pathway (WP375)

Wnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Binding of Wnt to its receptors leads to activation of at least 3 distinct pathways: i) the canonical beta catenin pathway, ii) the planar cell polarity pathway, and, iii) the calcium pathway. In the canonical beta catenin pathway, binding of Wnt to its receptors leads to stabilization of beta catenin in the cytosol followed by its translocation into the nucleus where it activates the transcription factor Tcf/Lef leading to upregulation of target genes. The non canonical planar cell polarity pathway involves activation of Dishevelled, small G proteins (Rho/Rac) and JNK. The non canonical calcium pathway involves activation of calcium sensitive kinases, PKC and CAMKII by Dishevelled. The Wnt signaling pathway is similar to the Hedgehog pathway in many respects. Abnormalities in the Wnt signaling pathway are associated with a large variety of human malignancies including tumors of breast, colon, pancreas, liver and bone. Source: [http://www.netpath.org/pathways?path_id=NetPath_8 NetPath] '''Additional comments:''' This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, pleaes cite the Cancer Cell Map and NetPath websites until the pathway is published.
last edited

Authors

A.Pandey, MaintBot, Thomas, Ddigles, Mkutmon, Egonw, and Eweitz

Cited In

Organism

Rattus norvegicus

Communities

Annotations

Pathway Ontology: Wnt signaling pathway

Participants

Label Type Compact Identifier
MGC112790 GeneProduct ncbigene:364754
Cdc2a GeneProduct ncbigene:54237
Csnk1d GeneProduct ncbigene:64462
Camk2d GeneProduct ncbigene:24246
Tcfap2a GeneProduct ncbigene:306862
Btrc GeneProduct ncbigene:361765
DVL2 GeneProduct ncbigene:303251
Bcl9 GeneProduct ensembl:ENSRNOG00000017516
Wnt5a GeneProduct ncbigene:64566
Wnt3 GeneProduct ncbigene:24882
Csnk2a2 GeneProduct ncbigene:307641
Mapk3 GeneProduct ncbigene:50689
Apc GeneProduct ncbigene:24205
Smad4 GeneProduct ensembl:ENSRNOG00000051965
LOC503000 GeneProduct ncbigene:503000
Raf1 GeneProduct ncbigene:24703
Dvl1 GeneProduct ncbigene:83721
Gsk3b GeneProduct ncbigene:84027
Smad3 GeneProduct ncbigene:25631
Jup GeneProduct ncbigene:81679
Tbp GeneProduct ncbigene:117526
Fzd1 GeneProduct ncbigene:58868
Dkk1 GeneProduct ncbigene:293897
Skp1a GeneProduct ncbigene:287280
Wnt1 GeneProduct ncbigene:24881
Mapk1 GeneProduct ncbigene:116590
Ctnnb1 GeneProduct ncbigene:84353
Dlgh2 GeneProduct ncbigene:64053
Pax2 GeneProduct ncbigene:293992
Fzd1 GeneProduct ncbigene:58868
Dlgh4 GeneProduct ncbigene:29495
Rhoa GeneProduct ncbigene:117273
Ctnnb1 GeneProduct ncbigene:84353
Arrb1 GeneProduct ncbigene:25387
Mapk9 GeneProduct ncbigene:50658
Ctbp2 GeneProduct ncbigene:81717
Cdc25c GeneProduct ncbigene:307511
Csnk2a1 GeneProduct ncbigene:116549
SOX1 GeneProduct None
Dab2 GeneProduct ncbigene:79128
Vangl2 GeneProduct ncbigene:289229
Map3k7 GeneProduct ncbigene:313121
Fzd1 GeneProduct ncbigene:58868
Wnt1 GeneProduct ncbigene:24881
Btrc GeneProduct ncbigene:361765
Camk2g GeneProduct ncbigene:171140
Sumo1 GeneProduct ncbigene:301442
Mapk8ip GeneProduct ncbigene:116457
Tcfe2a GeneProduct ncbigene:171046
Ppp2ca GeneProduct ncbigene:24672
Wnt1 GeneProduct ncbigene:24881
Wnt1 GeneProduct ncbigene:24881
Lrp5 GeneProduct ncbigene:293649
Lrp1 GeneProduct ncbigene:299858
CRYBB2 GeneProduct ncbigene:25422
Lef1 GeneProduct ncbigene:161452
Sfrp1 GeneProduct ncbigene:84402
Axin1 GeneProduct None
Fzd2 GeneProduct ncbigene:64512
Csnk2a1 GeneProduct ncbigene:116549
Magi3 GeneProduct ncbigene:245903
Prkca GeneProduct ncbigene:24680
RGD1561602 GeneProduct ncbigene:497961
SMT3H2 GeneProduct None
Rac1 GeneProduct ncbigene:363875
Fzd6 GeneProduct ncbigene:282581
Senp2 GeneProduct ncbigene:78973
Prkcb1 GeneProduct ncbigene:25023
Fzd1 GeneProduct ncbigene:58868
Sall1 GeneProduct ncbigene:307740
Fzd4 GeneProduct ncbigene:64558
FZD7 GeneProduct ncbigene:301440
Wnt2 GeneProduct ncbigene:114487
Apc GeneProduct ncbigene:24205
Fzd9 GeneProduct ncbigene:266608
Runx2 GeneProduct ncbigene:367218
Arrb2 GeneProduct ncbigene:25388
Akt1 GeneProduct ncbigene:24185
Map3k7 GeneProduct ncbigene:313121
Camk2a GeneProduct ncbigene:25400
Lef1 GeneProduct ncbigene:161452
Cul1 GeneProduct ncbigene:362356
Dvl1 GeneProduct ncbigene:83721
Axin2 GeneProduct ncbigene:29134
Csnk1e GeneProduct ncbigene:58822
HIPK2 GeneProduct ncbigene:362342
Ctnnb1 GeneProduct ncbigene:84353
Ctbp1 GeneProduct ncbigene:29382
Mark2 GeneProduct ncbigene:60328
Apc GeneProduct ncbigene:24205
Arrb2 GeneProduct ncbigene:25388
Axin1 GeneProduct ncbigene:79257
Apc GeneProduct ncbigene:24205
Cxxc4 GeneProduct ncbigene:83824
Map1b GeneProduct ncbigene:29456
Daam1 GeneProduct ncbigene:314212
Lrp6 GeneProduct ncbigene:312781
Cdc2a GeneProduct ncbigene:54237
Csnk2a2 GeneProduct ncbigene:307641
Ccnd1 GeneProduct ncbigene:58919
Wnt4 GeneProduct ncbigene:84426
Fhl2 GeneProduct ncbigene:63839
Sfrp2 GeneProduct ncbigene:310552
MYB GeneProduct ncbigene:293405
Akt1 GeneProduct ncbigene:24185
Wnt7a GeneProduct ncbigene:114850
Apc GeneProduct ncbigene:24205
Prkcc GeneProduct ncbigene:24681
Nr5a1 GeneProduct ncbigene:83826
Camk2b GeneProduct ncbigene:24245
Brd7 GeneProduct ncbigene:361374
Wnt1 GeneProduct ncbigene:24881
Pias4 GeneProduct ncbigene:362827
Ep300 GeneProduct ncbigene:170915
Mapk8 GeneProduct ncbigene:116554
TAX1BP3 GeneProduct ncbigene:360564
Fzd5 GeneProduct ncbigene:317674
Wnt3a GeneProduct ncbigene:303181
Tcf4 GeneProduct ncbigene:84382
Wnt2 GeneProduct ncbigene:114487
SOX9 GeneProduct ncbigene:140586
Wnt4 GeneProduct ncbigene:84426
Wnt3a GeneProduct ncbigene:303181
Cdh1 GeneProduct ncbigene:83502
DVL2 GeneProduct ncbigene:303251
Pin1 GeneProduct ncbigene:298696
Lrp6 GeneProduct ncbigene:312781
Fzd4 GeneProduct ncbigene:64558
Dlgh1 GeneProduct ncbigene:25252
Ror2 GeneProduct ncbigene:306782
Nkd1 GeneProduct ncbigene:364952
Axin1 GeneProduct ncbigene:79257
FRAT2 GeneProduct None
Gsk3b GeneProduct ncbigene:84027
Ruvbl1 GeneProduct ncbigene:65137
Csnk2b GeneProduct ncbigene:81650
LOC500430 GeneProduct ncbigene:500430
Csnk1a1 GeneProduct ncbigene:113927
Jun GeneProduct ncbigene:24516
Dvl1 GeneProduct ncbigene:83721
FRAT1 GeneProduct None
Dvl3 GeneProduct ncbigene:303811

References

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GSS, Venugopal AK, et al. NetPath: a public resource of curated signal transduction pathways. Genome Biol. 2010 Jan 12;11(1):R3. PubMed Europe PMC Scholia