The fatty acid synthesis of the roundworm C. Elegans is a highly conserved pathway evolutionary. This pathways is therefore of great importance to understand fat synthesis and nutrient sensing in adiposity regulation, which is key to understand the molecular mechanism behind obesity.

Authors

Kdahlquist , Maintenance bot , Chris Evelo , Egon Willighagen , Christine Chichester , Lauren J. Dupuis , Eric Weitz , Friederike Ehrhart , and Denise Slenter

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organism

Caenorhabditis elegans

Communities

Lipids and LIPID MAPS

Annotations

Pathway Ontology: fatty acid biosynthetic pathway

Participants

Label	Type	Compact Identifier
oxaloacetate	Metabolite	chebi:16452
3-ketoacyl-CoA	Metabolite	chebi:57347
Acetyl-CoA	Metabolite	hmdb:HMDB01206
Malonyl-CoA	Metabolite	hmdb:HMDB01175
Palmitate	Metabolite	chebi:15756
pyruvate	Metabolite	chebi:15361
citrate	Metabolite	chebi:133748
C32E8.9	GeneProduct	ncbigene:171951
F32H2.5	GeneProduct	ncbigene:172715
acs-17	GeneProduct	ncbigene:180859
F32H2.5	GeneProduct	ncbigene:172715
F32H2.5	GeneProduct	ncbigene:172715
Y25C1A.13	GeneProduct	ncbigene:173657
F32H2.5	GeneProduct	ncbigene:172715
Y65B4BL.5	GeneProduct	ncbigene:171643
pyc-1	GeneProduct	ncbigene:179616
F53C11.3	GeneProduct	ncbigene:179872
ech-2	GeneProduct	ncbigene:3564942
C36A4.9	GeneProduct	ncbigene:175500
D1005.1	GeneProduct	ncbigene:180485
fat-5	GeneProduct	ncbigene:180162
W09H1.5	GeneProduct	ncbigene:174963
F54C8.1	GeneProduct	ncbigene:186222
F32H2.5	GeneProduct	ncbigene:172715
ech-6	GeneProduct	ncbigene:176376
F32H2.5	GeneProduct	ncbigene:172715
F37C12.7	GeneProduct	ncbigene:176005
F32H2.5	GeneProduct	ncbigene:172715
Thiolases	GeneProduct	ncbigene:176756
F32H2.5	GeneProduct	ncbigene:172715

References

1. Watts JL. Fat synthesis and adiposity regulation in Caenorhabditis elegans. Trends Endocrinol Metab. 2009 Mar;20(2):58–65. PubMed Europe PMC Scholia