Apoptosis modulation by HSP70 (WP384)

This pathway summarizes the various ways by which HSP70 proteins can inhibit apoptosis. This pathway was originally adapted from rat. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP384 CPTAC Assay Portal]
last edited

Authors

I.Reyes, MaintBot, Khanspers, PaoloRomano, Jildau, AlexanderPico, Christine Chichester, Lorasimons, Egonw, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: apoptotic cell death pathway

Participants

Label Type Compact Identifier
TNFRSF1A GeneProduct ncbigene:7132
CASP9 GeneProduct ncbigene:842
CASP8 GeneProduct ncbigene:841
CASP2 GeneProduct ncbigene:835
FADD GeneProduct ncbigene:8772
MAP3K1 GeneProduct ncbigene:4214
RIPK1 GeneProduct ncbigene:8737
FADD GeneProduct ncbigene:8772
FAS GeneProduct ncbigene:355
CASP3 GeneProduct ncbigene:836
NF-kB Pathway Pathway None
NFKB1 GeneProduct ncbigene:4790
CYCS GeneProduct ncbigene:54205
HSPA1A GeneProduct ncbigene:3303
CASP6 GeneProduct ncbigene:839
HSPA1A GeneProduct ncbigene:3303
APAF1 GeneProduct ncbigene:317
CYCS GeneProduct ncbigene:54205
MAPK10 GeneProduct ncbigene:5602
CASP8 GeneProduct ncbigene:841
Apoptosis Pathway wikipathways:WP254
HSPA1A GeneProduct ncbigene:3303
FAS-Ligand GeneProduct ensembl:ENSG00000117560
BID GeneProduct ncbigene:637
CASP7 GeneProduct ncbigene:840
PDCD8 GeneProduct ncbigene:9131
TNF GeneProduct ensembl:ENSG00000204490

References

  1. Jäättelä M, Wissing D, Kokholm K, Kallunki T, Egeblad M. Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases. EMBO J. 1998 Nov 2;17(21):6124–34. PubMed Europe PMC Scholia
  2. Gabai VL, Meriin AB, Yaglom JA, Volloch VZ, Sherman MY. Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging. FEBS Lett. 1998 Oct 30;438(1–2):1–4. PubMed Europe PMC Scholia
  3. Schett G, Steiner CW, Gröger M, Winkler S, Graninger W, Smolen J, et al. Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70. FASEB J. 1999 May;13(8):833–42. PubMed Europe PMC Scholia
  4. Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES. Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat Cell Biol. 2000 Aug;2(8):476–83. PubMed Europe PMC Scholia
  5. Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, et al. The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mol Cell Biol. 2000 Oct;20(19):7146–59. PubMed Europe PMC Scholia
  6. Garrido C, Schmitt E, Candé C, Vahsen N, Parcellier A, Kroemer G. HSP27 and HSP70: potentially oncogenic apoptosis inhibitors. Cell Cycle. 2003;2(6):579–84. PubMed Europe PMC Scholia
  7. Gurbuxani S, Schmitt E, Cande C, Parcellier A, Hammann A, Daugas E, et al. Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor. Oncogene. 2003 Oct 2;22(43):6669–78. PubMed Europe PMC Scholia
  8. Orsini F, Migliaccio E, Moroni M, Contursi C, Raker VA, Piccini D, et al. The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential. J Biol Chem. 2004 Jun 11;279(24):25689–95. PubMed Europe PMC Scholia