Wnt signaling in kidney disease (WP3857)

This pathway is modeled after Figure 5 of the article "Glomerulocystic kidney disease" (Bissler, et al. 2010). The gene product Wnt signals two different paths titled canonical and non-canonical. The non-canonical path is mediated by the membrane bound protein Disheveled (Dvl) which then controls the planar cell Polarity. The canonical path on the other hand is mediated by the cytoplasmic protein Disheveled (Dvl) and then is effected through b-catenin transcription. The complex of Nphp2 and Nphp3 seem to help facilitate the process by controlling the Wnt signaling. Bergmann, et al. (2008) showed that Nphp3 deficiency in Xenopus resulted to planar cell polarity defects.
last edited

Authors

AAR&Co , Martina Summer-Kutmon , Alex Pico , Kristina Hanspers , Maintenance bot , Agustin Gonzalez-Vicente , and Eric Weitz

Cited In

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Organism

Mus musculus

Communities

Diseases

Annotations

Pathway Ontology: Wnt signaling pathway Wnt signaling, the planar cell polarity pathway

Disease Ontology: kidney disease

Participants

Label Type Compact Identifier
Calcium Metabolite hmdb:HMDB0000464
Nphp3 GeneProduct ncbigene:216799
Rhoa GeneProduct ncbigene:11848
beta-catenin GeneProduct ncbigene:12387
Nphp2 GeneProduct ncbigene:16348
Lrp5 GeneProduct ncbigene:16973
Lrp6 GeneProduct ncbigene:228357
Wnt1 GeneProduct ncbigene:22408
Wnt10a GeneProduct ncbigene:22409
Wnt10b GeneProduct ncbigene:22410
Wnt7a GeneProduct ncbigene:22421
Wnt16 GeneProduct ncbigene:93735
Wnt6 GeneProduct ncbigene:22420
Wnt5a GeneProduct ncbigene:22418
Wnt2b GeneProduct ncbigene:22414
Wnt11 GeneProduct ncbigene:22411
Wnt4 GeneProduct ncbigene:22417
Wnt3a GeneProduct ncbigene:22416
Wnt5b GeneProduct ncbigene:22419
Wnt9b GeneProduct ncbigene:22412
Wnt2 GeneProduct ncbigene:22413
Wnt3 GeneProduct ncbigene:22415
Wnt7b GeneProduct ncbigene:22422
Fzd1 GeneProduct ncbigene:14362
Fzd8 GeneProduct ncbigene:14370
Fzd4 GeneProduct ncbigene:14366
Fzd2 GeneProduct ncbigene:57265
Fzd7 GeneProduct ncbigene:14369
Fzd9 GeneProduct ncbigene:14371
Fzd5 GeneProduct ncbigene:14367
Fzd6 GeneProduct ncbigene:14368
Fzd3 GeneProduct ncbigene:14365
Fzd1 GeneProduct ncbigene:14362
Fzd8 GeneProduct ncbigene:14370
Fzd4 GeneProduct ncbigene:14366
Fzd2 GeneProduct ncbigene:57265
Fzd7 GeneProduct ncbigene:14369
Fzd9 GeneProduct ncbigene:14371
Fzd5 GeneProduct ncbigene:14367
Fzd6 GeneProduct ncbigene:14368
Fzd3 GeneProduct ncbigene:14365
Dvl2 GeneProduct ncbigene:13543
Dvl3 GeneProduct ncbigene:13544
Dvl1 GeneProduct ncbigene:13542
Mapk9 GeneProduct ncbigene:26420
Mapk10 GeneProduct ncbigene:26414
Mapk8 GeneProduct ncbigene:26419
Dvl2 GeneProduct ncbigene:13543
Dvl3 GeneProduct ncbigene:13544
Dvl1 GeneProduct ncbigene:13542
Gsk3B GeneProduct ncbigene:56637
Axin GeneProduct ncbigene:12005
Kitl GeneProduct ncbigene:17311
CsnK1a1 GeneProduct ncbigene:93687
APC GeneProduct ncbigene:11789
Btrc GeneProduct ncbigene:12234

References

  1. Bergmann C, Fliegauf M, Brüchle NO, Frank V, Olbrich H, Kirschner J, et al. Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia. Am J Hum Genet. 2008 Apr;82(4):959–70. PubMed Europe PMC Scholia
  2. Bissler JJ, Siroky BJ, Yin H. Glomerulocystic kidney disease. Pediatr Nephrol. 2010 Oct;25(10):2049–56; quiz 2056–9. PubMed Europe PMC Scholia
  3. Stamos JL, Weis WI. The β-catenin destruction complex. Cold Spring Harb Perspect Biol. 2013 Jan 1;5(1):a007898. PubMed Europe PMC Scholia