T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection (WP3863)

This pathway is based on Figure 4 of "A Model of an Integrated Immune System Pathway in Homo sapiens and Its Interaction with Superantigen Producing Expression Regulatory Pathway in Staphylococcus aureus: Comparing Behavior of Pathogen Perturbed and Unperturbed Pathway"(see bibliography). The pathway displays the T-cell receptors of homo sapiens when infected with the disease Staphylococcus Enterotoxin B. The binding of a superantigen to the T cell receptor results in a protein signaling pathway resulting in cell proliferation, differentiation, and immune response due to altered DNA expression. SEB refers to Staphylococcal Enterotoxin B.
last edited

Authors

AAR&Co, Egonw, Mkutmon, Khanspers, AlexanderPico, Evelo, AMTan, MaintBot, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Diseases

Annotations

Pathway Ontology: infectious disease pathway immune response pathway

Cell Type Ontology: T cell

Disease Ontology: toxic shock syndrome

Participants

Label Type Compact Identifier
DAG1 GeneProduct ensembl:ENSG00000173402
SHP1 GeneProduct ensembl:ENSG00000111679
PIP3 Metabolite hmdb:HMDB0010147
PLCG1 GeneProduct ensembl:ENSG00000124181
NFKBIA GeneProduct ensembl:ENSG00000100906
PRKCQ GeneProduct ensembl:ENSG00000065675
RAF GeneProduct ensembl:ENSG00000132155
TNF GeneProduct ensembl:ENSG00000232810
IL2 GeneProduct ensembl:ENSG00000109471
GRB2 GeneProduct ensembl:ENSG00000177885
NCK GeneProduct ensembl:ENSG00000158092
NIK GeneProduct ensembl:ENSG00000006062
PTPRC GeneProduct ensembl:ENSG00000081237
RAS GeneProduct ensembl:ENSG00000126458
SLP76 GeneProduct ensembl:ENSG00000043462
CBL GeneProduct ensembl:ENSG00000110395
COT GeneProduct ensembl:ENSG00000107968
AKT GeneProduct ensembl:ENSG00000142208
JUN GeneProduct ensembl:ENSG00000177606
CHP1 GeneProduct ensembl:ENSG00000187446
GADS GeneProduct ensembl:ENSG00000100351
IL4 GeneProduct ensembl:ENSG00000113520
IP3 Metabolite pubchem.compound:439456
DLGH1 GeneProduct ensembl:ENSG00000075711
TRAJ10 GeneProduct ensembl:ENSG00000211879
IKBKG GeneProduct ensembl:ENSG00000269335
AP1 GeneProduct ensembl:ENSG00000177606
Calmodulin Protein ensembl:ENSG00000198668
ERK GeneProduct ensembl:ENSG00000102882
MEK2 GeneProduct ensembl:ENSG00000126934
MEK1 GeneProduct ensembl:ENSG00000169032
IKBKB GeneProduct ensembl:ENSG00000104365
CD8A GeneProduct ensembl:ENSG00000153563
LAT GeneProduct ensembl:ENSG00000213658
IL10 GeneProduct ensembl:ENSG00000136634
MALT1 GeneProduct ensembl:ENSG00000172175
PDK1 GeneProduct ensembl:ENSG00000152256
FYN GeneProduct ensembl:ENSG00000010810
PI3K GeneProduct ensembl:ENSG00000121879
LCK GeneProduct ensembl:ENSG00000182866
CTLA4 GeneProduct ensembl:ENSG00000163599
MKK7 GeneProduct ensembl:ENSG00000076984
CD3D GeneProduct ensembl:ENSG00000167286
AHSA1 GeneProduct ensembl:ENSG00000100591
NFKB1 GeneProduct ensembl:ENSG00000109320
CD40L GeneProduct ensembl:ENSG00000102245
JNK2 GeneProduct ensembl:ENSG00000050748
ITK GeneProduct ensembl:ENSG00000113263
IFNG GeneProduct ensembl:ENSG00000111537
CD4 GeneProduct ensembl:ENSG00000010610
CARMA1 GeneProduct ensembl:ENSG00000198286
PD1 GeneProduct ensembl:ENSG00000188389
IL5 GeneProduct ensembl:ENSG00000113525
BCL10 GeneProduct ensembl:ENSG00000142867
FOS GeneProduct ensembl:ENSG00000170345
PAK GeneProduct ensembl:ENSG00000149269
CSF2 GeneProduct ensembl:ENSG00000164400
TRBJ1-4 GeneProduct ensembl:ENSG00000281958
GSK3B GeneProduct ensembl:ENSG00000082701
SOS GeneProduct ensembl:ENSG00000115904
CD28 GeneProduct ensembl:ENSG00000178562
GRP1 GeneProduct uniprot:O08967
Calcium Metabolite hmdb:HMDB0000464
TAK1 GeneProduct ensembl:ENSG00000135341
CDK4 GeneProduct ensembl:ENSG00000135446
ICOS GeneProduct ensembl:ENSG00000163600
NFAT GeneProduct ensembl:ENSG00000101096
ZAP70 GeneProduct ensembl:ENSG00000115085
CHUK GeneProduct ensembl:ENSG00000213341
GRB2 GeneProduct ensembl:ENSG00000177885
RAS GeneProduct ensembl:ENSG00000126458
Calcium Metabolite hmdb:HMDB0000464
Calmodulin Protein uniprot:P62204

References

  1. Tomar N, De RK. A model of an integrated immune system pathway in Homo sapiens and its interaction with superantigen producing expression regulatory pathway in Staphylococcus aureus: comparing behavior of pathogen perturbed and unperturbed pathway. PLoS One. 2013 Dec 6;8(12):e80918. PubMed Europe PMC Scholia