Novel intracellular components of RIG-I-like receptor (RLR) pathway (WP3865)

Viral pathogen RNA are recognized by host helicases called RIG-I-like receptors (RLRs) that include DDX58 (RIG-I), DHX58 (LGP2), IFIH1 (MDA5), SNW1, and DDX17. These RLR proteins then go on to initiate signaling pathways, triggering the innate antiviral response via production of type I interferons and inflammatory cytokines. RLR pathway genes are characterized by rapid evolution, viral protein interactions, limited sets of protein domains, specific TF regulation, and densely connected interaction networks. The study by van der Lee et al. (2015) identfied novel components, DDX17 and SNW1, for the RIG-I pathway. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]
last edited


AlexanderPico, Yt, and Khanspers

Cited In


Homo sapiens



Pathway Ontology: signaling pathway signaling pathway in the innate immune response

Disease Ontology: viral infectious disease


Label Type Compact Identifier
MAPK8 GeneProduct ensembl:ENSG00000107643
MAPK14 GeneProduct ensembl:ENSG00000112062
MAPK13 GeneProduct ensembl:ENSG00000156711
MAPK12 GeneProduct ensembl:ENSG00000188130
MAPK11 GeneProduct ensembl:ENSG00000185386
DDX17 GeneProduct ensembl:ENSG00000100201
short dsRNA Rna None
Ub-mediated proteolysis Pathway wikipathways:WP183
DDX3Y GeneProduct ensembl:ENSG00000067048
TMEM173 GeneProduct ensembl:ENSG00000184584
CYLD GeneProduct ensembl:ENSG00000083799
CXCL8 GeneProduct ensembl:ENSG00000169429
Apoptosis Pathway wikipathways:WP254
DDX58 GeneProduct ensembl:ENSG00000107201
ISG15 GeneProduct ensembl:ENSG00000187608
TRIM25 GeneProduct ensembl:ENSG00000121060
ATG5 GeneProduct ensembl:ENSG00000057663
ATG12 GeneProduct ensembl:ENSG00000145782
NLRX1 GeneProduct ensembl:ENSG00000160703
MAVS GeneProduct ensembl:ENSG00000088888
DHX58 GeneProduct ensembl:ENSG00000108771
RNF125 GeneProduct ensembl:ENSG00000101695
IFIH1 GeneProduct ensembl:ENSG00000115267
DAK GeneProduct ensembl:ENSG00000149476
OTUD5 GeneProduct ensembl:ENSG00000068308
TRAF3 GeneProduct ensembl:ENSG00000131323
TRADD GeneProduct ensembl:ENSG00000102871
TANK GeneProduct ensembl:ENSG00000136560
AZI2 GeneProduct ensembl:ENSG00000163512
TBKBP1 GeneProduct ensembl:ENSG00000198933
FADD GeneProduct ensembl:ENSG00000168040
RIPK1 GeneProduct ensembl:ENSG00000137275
SIKE1 GeneProduct ensembl:ENSG00000052723
IKBKE GeneProduct ensembl:ENSG00000263528
TBK1 GeneProduct ensembl:ENSG00000183735
IKBKG GeneProduct ensembl:ENSG00000269335
CASP8 GeneProduct ensembl:ENSG00000064012
CASP10 GeneProduct ensembl:ENSG00000003400
DDX3X GeneProduct ensembl:ENSG00000215301
PIN1 GeneProduct ensembl:ENSG00000127445
IRF3 GeneProduct ensembl:ENSG00000126456
IRF7 GeneProduct ensembl:ENSG00000185507
IKBKG GeneProduct ensembl:ENSG00000269335
CHUK GeneProduct ensembl:ENSG00000213341
IKBKB GeneProduct ensembl:ENSG00000104365
NFKBIA GeneProduct ensembl:ENSG00000100906
NFKBIB GeneProduct ensembl:ENSG00000104825
NFKB1 GeneProduct ensembl:ENSG00000109320
RELA GeneProduct ensembl:ENSG00000173039
MAPK10 GeneProduct ensembl:ENSG00000109339
MAPK9 GeneProduct ensembl:ENSG00000050748
MAP3K7 GeneProduct ensembl:ENSG00000135341
MAP3K1 GeneProduct ensembl:ENSG00000095015
TRAF2 GeneProduct ensembl:ENSG00000127191
TRAF6 GeneProduct ensembl:ENSG00000175104
IRF3 GeneProduct ensembl:ENSG00000126456
IRF7 GeneProduct ensembl:ENSG00000185507
NFKB1 GeneProduct ensembl:ENSG00000109320
RELA GeneProduct ensembl:ENSG00000173039
IFNG GeneProduct ensembl:ENSG00000111537
IFNA1 GeneProduct ensembl:ENSG00000197919
IFNB1 GeneProduct ensembl:ENSG00000171855
IFNE GeneProduct ensembl:ENSG00000184995
IFNK GeneProduct ensembl:ENSG00000147896
TNFA Protein ensembl:ENSG00000232810
CXCL12 GeneProduct ensembl:ENSG00000107562
CXCL10 GeneProduct ensembl:ENSG00000169245
5ppp-RNA Rna None
long dsRNA Rna None
Ub-mediated proteolysis Pathway WikiPathways
MAPK signaling Pathway WikiPathways
ISG15 GeneProduct Ensembl
SNW1 GeneProduct Ensembl
viral RNA Rna None
viral RNA Rna None


  1. van der Lee R, Feng Q, Langereis MA, Ter Horst R, Szklarczyk R, Netea MG, et al. Integrative Genomics-Based Discovery of Novel Regulators of the Innate Antiviral Response. PLoS Comput Biol. 2015 Oct 20;11(10):e1004553. PubMed Europe PMC Scholia