Regulation of apoptosis by parathyroid hormone-related protein (WP3872)

This pathway is based on Figure 8 of "Parathyroid hormone-related protein regulates cell survival pathways via integrin alpha6beta4-mediated activation of phosphatidylinositol 3-kinase/Akt signaling."(See Bibliography). Parathyroid Hormone-related Protein Regulates Cell Survival Pathways via Integrin alpha6beta4-mediated Activation of PI3-K/Akt Signaling Intracrine PTHrP inhibits apoptosis by activating the PI3-K/Akt pathway by increasing levels of integrin A6B4, which signals in harmony with growth factor receptors. The activation of Akt increases the ratio of anti-apoptosis members to pro-apoptosis members in the Bcl-2 Family. The activation of Akt deactivates GSK-3 which leads to higher levels of c-myc, therefore leading to lower levels of apoptosis. Overall, intracrine PTHrP has the effect of increased cell survival on C4-2 cells. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3872 CPTAC Assay Portal]
last edited

Authors

AAR&Co, Fehrhart, Egonw, Khanspers, AlexanderPico, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: regulatory pathway

Disease Ontology: prostate cancer

Participants

Label Type Compact Identifier
GSK3A GeneProduct ensembl:ENSG00000105723
AKT1 GeneProduct ensembl:ENSG00000142208
BCL2L10 GeneProduct ensembl:ENSG00000137875
MCL-1 Protein uniprot:Q07820
Integrin A6 GeneProduct ensembl:ENSG00000091409
BOK GeneProduct ensembl:ENSG00000176720
BCL2L12 GeneProduct ensembl:ENSG00000126453
BCL2A1 GeneProduct ensembl:ENSG00000140379
BCL2L15 GeneProduct ensembl:ENSG00000188761
siRNA B4 Rna None
Integrin B4 GeneProduct ensembl:ENSG00000132470
Apoptosis Pathway wikipathways:WP254
siRNA A6 Rna None
GSK3B GeneProduct ensembl:ENSG00000082701
MYC GeneProduct ensembl:ENSG00000136997
Intracrine PTHrP GeneProduct ensembl:ENSG00000087494
Growth Factor Receptors GeneProduct None
BID GeneProduct ensembl:ENSG00000015475
BCL2L1 GeneProduct ensembl:ENSG00000171552
PI3-K GeneProduct ensembl:ENSG00000105851
BCL2L2 GeneProduct ensembl:ENSG00000129473
BAK1 GeneProduct ensembl:ENSG00000030110
BCL2L14 GeneProduct ensembl:ENSG00000121380
BCL2 GeneProduct ensembl:ENSG00000171791
BAX GeneProduct ensembl:ENSG00000087088
BCL2L13 GeneProduct ensembl:ENSG00000099968
BCL-2 family GeneProduct None

References

  1. Bhatia V, Mula RV, Weigel NL, Falzon M. Parathyroid hormone-related protein regulates cell survival pathways via integrin alpha6beta4-mediated activation of phosphatidylinositol 3-kinase/Akt signaling. Mol Cancer Res. 2009 Jul;7(7):1119–31. PubMed Europe PMC Scholia