ATM signaling in development and disease (WP3878)

This pathway is modeled after Figure 4 in the article "The ATM signaling network in development and disease" (See Bibliography). When DNA is damaged, DDR begins to work on recuperating the damage through the appropriate cellular programs such as transcription, translation, etc etc. The ataxia-telangiectasia mutated (ATM) kinase acts as the main core of this pathway acting upon or receiving a lot of the reactions towards other gene products. ATM substrates use several different cell cycle checkpoints to determine the health of the DNA, and determine different types of disease/damage done to the DNA. The p38MAPK which is a reaction by ATM later leads to HSP27 which inhibits oxidative stress within the cell. DDR and ATM both work to help the cell recover from any damage it has received and understanding how ATM works will help increase doctors and scientists understanding of diseases, and their treatment. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3878 CPTAC Assay Portal]
last edited

Authors

AAR&Co, Khanspers, MaintBot, and Eweitz

Cited In

Organism

Homo sapiens

Communities

CPTAC

Annotations

Pathway Ontology: G1 phase pathway DNA repair pathway

Participants

Label Type Compact Identifier
Cdc25 GeneProduct ensembl:ENSG00000058335
HSP27 GeneProduct ensembl:ENSG00000106211
HMGN1 GeneProduct ensembl:ENSG00000205581
RNF20 GeneProduct ensembl:ENSG00000155827
RNF168 GeneProduct ensembl:ENSG00000163961
CHK1 GeneProduct ensembl:ENSG00000149554
ATR GeneProduct ensembl:ENSG00000175054
LKB1 GeneProduct ensembl:ENSG00000118046
ATM GeneProduct ensembl:ENSG00000149311
uH2A GeneProduct None
CDK GeneProduct ensembl:ENSG00000170312
ATM GeneProduct ensembl:ENSG00000149311
MRE11A GeneProduct ensembl:ENSG00000020922
CEP63 GeneProduct ensembl:ENSG00000182923
KAP1 GeneProduct ensembl:ENSG00000130726
G6PD GeneProduct ensembl:ENSG00000160211
PP5 GeneProduct ensembl:ENSG00000011485
PPP2R4 GeneProduct ensembl:ENSG00000119383
MRE11B GeneProduct ensembl:ENSG00000242537
Reactive Oxygen Species Metabolite hmdb:HMDB0003125
WIP1 GeneProduct ensembl:ENSG00000170836
ATF2 GeneProduct ensembl:ENSG00000115966
H2AX GeneProduct ensembl:ENSG00000188486
mTORC1 GeneProduct ensembl:ENSG00000198793
ATMIN GeneProduct ensembl:ENSG00000166454
RNF8 GeneProduct ensembl:ENSG00000112130
CHK2 GeneProduct ensembl:ENSG00000183765
NF-KB GeneProduct ensembl:ENSG00000109320
Artemis GeneProduct ensembl:ENSG00000152457
NEMO GeneProduct ensembl:ENSG00000269335
p38MAPK GeneProduct ensembl:ENSG00000197442
RIF1 GeneProduct ensembl:ENSG00000080345
HDAC4 GeneProduct ensembl:ENSG00000068024
MDC1 GeneProduct ensembl:ENSG00000137337
Nbs1 GeneProduct ensembl:ENSG00000104320
CDK5 GeneProduct ensembl:ENSG00000164885
53BP1 GeneProduct ensembl:ENSG00000067369
XLF GeneProduct ensembl:ENSG00000152457
Rad50 GeneProduct ensembl:ENSG00000113522
PPP2R4 GeneProduct ensembl:ENSG00000119383
Lamin-B GeneProduct ensembl:ENSG00000143815
CTIP GeneProduct ensembl:ENSG00000101773
HMGN1 GeneProduct ensembl:ENSG00000205581
SMC1 GeneProduct ensembl:ENSG00000072501
DNAPKcs GeneProduct ensembl:ENSG00000253729
uH2B GeneProduct None
p38 GeneProduct ensembl:ENSG00000176749
TIP60 GeneProduct ensembl:ENSG00000172977
Bub1 GeneProduct ensembl:ENSG00000169679
AMPK GeneProduct ensembl:ENSG00000132356
RNF40 GeneProduct ensembl:ENSG00000103549
Cell Cycle Pathway wikipathways:WP45
Aurora B GeneProduct ensembl:ENSG00000178999
TSC2 GeneProduct ensembl:ENSG00000103197
ATM GeneProduct ensembl:ENSG00000149311
ATM GeneProduct ensembl:ENSG00000149311
ATM GeneProduct ensembl:ENSG00000149311
MRE11A GeneProduct ensembl:ENSG00000020922
Rad50 GeneProduct ensembl:ENSG00000113522
Nbs1 GeneProduct ensembl:ENSG00000104320
ATM GeneProduct ensembl:ENSG00000149311
Nbs1 GeneProduct ensembl:ENSG00000104320
MRE11A GeneProduct ensembl:ENSG00000020922
Rad50 GeneProduct ensembl:ENSG00000113522
ATM GeneProduct ensembl:ENSG00000149311
ATM GeneProduct ensembl:ENSG00000149311
MRE11B GeneProduct ensembl:ENSG00000242537
MRE11B GeneProduct ensembl:ENSG00000242537

References

  1. Stracker TH, Roig I, Knobel PA, Marjanović M. The ATM signaling network in development and disease. Front Genet. 2013 Mar 25;4:37. PubMed Europe PMC Scholia