Proximal tubule transporters (WP3881)

The proximal tubule of the nephron reabsorbs approximately two-thirds of the Na filtered through the glomerulus. Na extrusion from the cell by the basolateral Na/K-ATPase provides the gradient for apical Na entry, and for reabsorption of glucose, phosphate, amino acids and other component of the ultrafiltrate. This pathway organizes several of the transporters present in the proximal tubule by their function and it is based in deep-sequencing and physiological data.
last edited

Authors

AgustinGV, AlexanderPico, Khanspers, and Eweitz

Cited In

Organism

Rattus norvegicus

Communities

Annotations

Pathway Ontology: ion transport pathway transport pathway regulatory pathway

Cell Type Ontology: nephron tubule epithelial cell epithelial cell of proximal tubule kidney proximal convoluted tubule epithelial cell

Participants

Label Type Compact Identifier
NHE3 GeneProduct ncbigene:24784
NHE3 RegP1 GeneProduct ncbigene:59114
NHE3 RegP2 GeneProduct ncbigene:116501
NHE8 GeneProduct ncbigene:311651
CA II GeneProduct ncbigene:54231
CA VII GeneProduct ncbigene:291819
CA IV GeneProduct ncbigene:29242
CA XII GeneProduct ncbigene:363085
CA XIV GeneProduct ncbigene:791259
CA XV GeneProduct ncbigene:288360
PAT1 GeneProduct ncbigene:301010
SAT1 GeneProduct ncbigene:64076
OAT1 GeneProduct ncbigene:29509
OAT3 GeneProduct ncbigene:83500
NaPi-2a GeneProduct ncbigene:25548
NaPi-2b GeneProduct ncbigene:84395
Pit-2 GeneProduct ncbigene:29502
NAS1 GeneProduct ncbigene:58980
NBC GeneProduct ncbigene:84484
NaDC-1 GeneProduct ncbigene:65202
NaDC-3 GeneProduct ncbigene:64846
Atp1a1 GeneProduct ncbigene:24211
Atp1b1 GeneProduct ncbigene:25650
Atp1b3 GeneProduct ncbigene:25390
Gamma 1 GeneProduct ncbigene:29639
CHIF GeneProduct ncbigene:64190
B*AT1 GeneProduct ncbigene:664630
E. Glutam. Tr. GeneProduct ncbigene:25550
SNAT7 GeneProduct ncbigene:291840
LAT3-4F2hc GeneProduct ncbigene:307811
OCTN2 GeneProduct ncbigene:29726
BAT-1 GeneProduct ncbigene:116726
LAT1-4F2hc GeneProduct ncbigene:83509
LAT3-4F2hc GeneProduct ncbigene:84551
TAT1 GeneProduct ncbigene:170566
Atp6v1a GeneProduct ncbigene:685232
Atp6v1b1 GeneProduct ncbigene:312488
Atp6v1b2 GeneProduct ncbigene:117596
Atp6v1c1 GeneProduct ncbigene:299971
Atp6v1d GeneProduct ncbigene:299159
Atp6v1e1 GeneProduct ncbigene:297566
Atp6v1f GeneProduct ncbigene:116664
Atp6v1g1 GeneProduct ncbigene:298103
Atp6v1g3 GeneProduct ncbigene:289407
Atp6v1h GeneProduct ncbigene:297797
Atp6v0a1 GeneProduct ncbigene:29757
Atp6v0a2 GeneProduct ncbigene:116455
Atp6v0a4 GeneProduct ncbigene:296981
Atp6v0b GeneProduct ncbigene:298451
Atp6v0c GeneProduct ncbigene:170667
Atp6v0d1 GeneProduct ncbigene:291969
Atp6v0d2 GeneProduct ncbigene:297932
Atp6v0e1 GeneProduct ncbigene:94170
Atp6v0e2 GeneProduct ncbigene:436582

References

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  2. Purkerson JM, Schwartz GJ. The role of carbonic anhydrases in renal physiology. Kidney Int. 2007 Jan;71(2):103–15. PubMed Europe PMC Scholia
  3. Curthoys NP, Moe OW. Proximal tubule function and response to acidosis. Clin J Am Soc Nephrol. 2014 Sep 5;9(9):1627–38. PubMed Europe PMC Scholia
  4. Lee JW, Chou C-L, Knepper MA. Deep Sequencing in Microdissected Renal Tubules Identifies Nephron Segment-Specific Transcriptomes. J Am Soc Nephrol. 2015 Nov;26(11):2669–77. PubMed Europe PMC Scholia