Thick ascending limb transporters (WP3882)

This pathway shows the main transporters in the thick ascending limb of the Loop of Henle
last edited

Authors

AgustinGV, MaintBot, AlexanderPico, Khanspers, Egonw, DeSl, and Eweitz

Cited In

Organism

Rattus norvegicus

Communities

Annotations

Cell Type Ontology: transporting cell kidney loop of Henle thick ascending limb epithelial cell kidney epithelial cell

Pathway Ontology: transport pathway regulatory pathway

Disease Ontology: Bartter disease

Participants

Label Type Compact Identifier
NHE3 GeneProduct ncbigene:24784
Na Metabolite hmdb:HMDB0000588
NBCn1 GeneProduct ncbigene:117955
ROMK 2/3 GeneProduct ncbigene:24521
NKCC2 GeneProduct ncbigene:25065
ATP1A1 GeneProduct ncbigene:24211
K Metabolite hmdb:HMDB0000586
2 Cl Metabolite hmdb:HMDB0000492
K Metabolite hmdb:HMDB0000586
K Metabolite hmdb:HMDB0000586
2 K Metabolite hmdb:HMDB0000586
2 K Metabolite hmdb:HMDB0000586
3 Na Metabolite hmdb:HMDB0000588
3 Na Metabolite hmdb:HMDB0000588
Na Metabolite hmdb:HMDB0000588
Na Metabolite hmdb:HMDB0000588
H Metabolite hmdb:HMDB0059597
H Metabolite hmdb:HMDB0059597
CO2 Metabolite hmdb:HMDB0001967
H2O Metabolite hmdb:HMDB0002111
H Metabolite hmdb:HMDB0059597
HCO3 Metabolite hmdb:HMDB0000595
HCO3 Metabolite hmdb:HMDB0000595
Na Metabolite hmdb:HMDB0000588
HCO3 Metabolite hmdb:HMDB0000595
Na Metabolite hmdb:HMDB0000588
Cl Metabolite hmdb:HMDB0000492
Cl Metabolite hmdb:HMDB0000492
Barttin GeneProduct ncbigene:79430
Na Metabolite hmdb:HMDB0000588
K Metabolite hmdb:HMDB0000586
2 Cl Metabolite hmdb:HMDB0000492
KCC4 GeneProduct ncbigene:308069
K Metabolite hmdb:HMDB0000586
K Metabolite hmdb:HMDB0000586
Cl Metabolite hmdb:HMDB0000492
Cl Metabolite hmdb:HMDB0000492
Aquaporin 1 GeneProduct ncbigene:25240
H2O Metabolite hmdb:HMDB0002111
H2O Metabolite hmdb:HMDB0002111
CLC-K2 GeneProduct ncbigene:79430
CA2 GeneProduct ncbigene:54231
CA4 GeneProduct ncbigene:29242
CO2 Metabolite hmdb:HMDB0001967
H2O Metabolite hmdb:HMDB0002111
H Metabolite hmdb:HMDB0059597
HCO3 Metabolite hmdb:HMDB0000595
ATP Metabolite hmdb:HMDB0000538
ADP Metabolite hmdb:HMDB0001341
ATP1B1 GeneProduct ncbigene:25650
K Channels GeneProduct Entrez Gene
K Metabolite hmdb:HMDB0000586
K Metabolite hmdb:HMDB0000586
KCNK12 GeneProduct ncbigene:64119
KCNQ1 GeneProduct ncbigene:84020
KCNK13 GeneProduct ncbigene:64120
KCNJ13 GeneProduct ncbigene:94341
KCNJ16 GeneProduct ncbigene:29719
Fxyd2 GeneProduct ncbigene:29639
CLC-K1 GeneProduct ncbigene:79425
NHE2 GeneProduct ncbigene:24783

References

  1. Greger R. Ion transport mechanisms in thick ascending limb of Henle’s loop of mammalian nephron. Physiol Rev. 1985 Jul;65(3):760–97. PubMed Europe PMC Scholia
  2. Hebert SC, Andreoli TE. Control of NaCl transport in the thick ascending limb. Am J Physiol. 1984 Jun;246(6 Pt 2):F745-56. PubMed Europe PMC Scholia
  3. Féraille E, Doucet A. Sodium-potassium-adenosinetriphosphatase-dependent sodium transport in the kidney: hormonal control. Physiol Rev. 2001 Jan;81(1):345–418. PubMed Europe PMC Scholia
  4. Hamilton KL, Devor DC. Basolateral membrane K+ channels in renal epithelial cells. Am J Physiol Renal Physiol. 2012 May 1;302(9):F1069-81. PubMed Europe PMC Scholia
  5. Cabral PD, Herrera M. Membrane-associated aquaporin-1 facilitates osmotically driven water flux across the basolateral membrane of the thick ascending limb. Am J Physiol Renal Physiol. 2012 Sep;303(5):F621-9. PubMed Europe PMC Scholia
  6. Mount DB. Thick ascending limb of the loop of Henle. Clin J Am Soc Nephrol. 2014 Nov 7;9(11):1974–86. PubMed Europe PMC Scholia
  7. Lee JW, Chou C-L, Knepper MA. Deep Sequencing in Microdissected Renal Tubules Identifies Nephron Segment-Specific Transcriptomes. J Am Soc Nephrol. 2015 Nov;26(11):2669–77. PubMed Europe PMC Scholia