Angiotensin II signaling (acute) in thick ascending limbs (WP3887)

The thick ascending limb of the loop pf Henle reabsorbs 25 to 30 % of the NaCl filtered through the glomerulus. Abnormally elevated Na reabsorption by this segment is link to salt-sensitive hypertension. Ang II is an important regulator of transport in the thick ascending limb, in part due to its modulatory effects on the balance between nitric oxide and superoxide. This pathway features the acute effects of Ang II in NO and O2- production in thick ascending limb. The information presented here is based on both genomic and physiological data.
last edited


AgustinGV, AlexanderPico, Egonw, Khanspers, Susan, DeSl, MaintBot, and Mkutmon

Cited In


Rattus norvegicus



Pathway Ontology: angiotensin signaling pathway renin-angiotensin cascade pathway signaling pathway

Disease Ontology: renal hypertension

Cell Type Ontology: kidney loop of Henle thick ascending limb epithelial cell


Label Type Compact Identifier
PIP2 Metabolite chemspider:21169207
Itpr3 GeneProduct ncbigene:25679
Itpr1 GeneProduct ncbigene:25262
Superoxide Metabolite hmdb:HMDB0002168
Itpr2 GeneProduct ncbigene:81678
Ca2+ Metabolite hmdb:HMDB0000464
PKCa GeneProduct ncbigene:24680
IP3 Metabolite hmdb:HMDB0001498
cAMP Metabolite hmdb:HMDB0000058
Mas1 Protein ncbigene:25153
DAG Metabolite chebi:18035
PLC g2 GeneProduct ncbigene:29337
G alfa-Q GeneProduct ncbigene:81666
AT2R GeneProduct ncbigene:24182
PKA Protein rgd:3389
AT1a GeneProduct ncbigene:24180
NO Metabolite hmdb:HMDB0003378
PI3K Protein None
AT1b GeneProduct ncbigene:81638
AT1R AP GeneProduct ncbigene:298646
B-Arrestin 2 GeneProduct ncbigene:25388
Dynamin 1 GeneProduct ncbigene:140694
Dynamin 2 GeneProduct ncbigene:25751
G alfa-11 GeneProduct ncbigene:81662
PLC g1 GeneProduct ncbigene:25738
Ca2+ Metabolite hmdb:HMDB0000464
PIP2 Metabolite chemspider:21169207
PIP3 Metabolite wikidata:Q3078767
PTEN Protein ncbigene:50557
Akt2 / PKB Protein ncbigene:25233
Akt1 / PKB Protein ncbigene:24185
Akt3 / PKB Protein ncbigene:29414
NOS3 GeneProduct ncbigene:24600
Calmodulin 1 GeneProduct ncbigene:24242
Calmodulin 2 GeneProduct ncbigene:50663
Calmodulin 3 GeneProduct ncbigene:24244
NOX4 GeneProduct ncbigene:85431
Rac1 GeneProduct ncbigene:85431
PKCa GeneProduct ncbigene:24680
PKCg GeneProduct ncbigene:24681
AMP Metabolite hmdb:HMDB0003540
PDE 2a GeneProduct ncbigene:81743
Uncoupled NOSs GeneProduct ncbigene:24600
PDPK1 GeneProduct ncbigene:81745
PLA2 GeneProduct Entrez Gene
AA Metabolite chebi:15843
20-HETE Metabolite hmdb:HMDB0005998
cit-P450 GeneProduct Entrez Gene


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