Chemokine signaling pathway (WP3929)

Chemokines are small cytokines, or signaling proteins, secreted by cells. A major rol of chemokines is to act as chemoattractants in guiding migration of cells. Chemokine signals are transduced by G-protein coupled receptors, which dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. This pathway was adapted from [http://www.genome.jp/dbget-bin/www_bget?pathway:map04062 KEGG] Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3929 CPTAC Assay Portal]
last edited

Authors

Khanspers and Finterly

Cited In

Organism

Homo sapiens

Communities

CPTAC

Annotations

Pathway Ontology: chemokine mediated signaling pathway chemokine mediated signaling pathway

Participants

Label Type Compact Identifier
CX3CR1 GeneProduct ensembl:ENSG00000168329
ARRB2 GeneProduct ensembl:ENSG00000141480
CXCL16 GeneProduct ensembl:ENSG00000161921
GNGT2 GeneProduct ensembl:ENSG00000167083
CCL27 GeneProduct ensembl:ENSG00000213927
CRKL GeneProduct ensembl:ENSG00000099942
GNG4 GeneProduct ensembl:ENSG00000168243
CCL22 GeneProduct ensembl:ENSG00000102962
PIK3R1 GeneProduct ensembl:ENSG00000145675
VAV2 GeneProduct ensembl:ENSG00000160293
FOXO3 GeneProduct ensembl:ENSG00000118689
PRKACG GeneProduct ensembl:ENSG00000165059
ADCY2 GeneProduct ensembl:ENSG00000078295
CCL17 GeneProduct ensembl:ENSG00000102970
GSK3B GeneProduct ensembl:ENSG00000082701
Gm11787 GeneProduct None
PPBP GeneProduct ensembl:ENSG00000163736
CRK GeneProduct ensembl:ENSG00000167193
GNG10 GeneProduct ensembl:ENSG00000242616
PRKCB GeneProduct ensembl:ENSG00000166501
GNAI2 GeneProduct ensembl:ENSG00000114353
RAC2 GeneProduct ensembl:ENSG00000128340
RAC1 GeneProduct ensembl:ENSG00000136238
JAK2 GeneProduct ensembl:ENSG00000096968
CDC42 GeneProduct ensembl:ENSG00000070831
RAF1 GeneProduct ensembl:ENSG00000132155
Gm5741 GeneProduct None
PREX1 GeneProduct ensembl:ENSG00000124126
Calcium Metabolite kegg.compound:C00076
CCL4 GeneProduct ensembl:ENSG00000275302
GNB5 GeneProduct ensembl:ENSG00000069966
PIK3R2 GeneProduct ensembl:ENSG00000105647
Phosphatidylinositol-3,4,5-trisphosphate Metabolite kegg.compound:C05981
GNG5 GeneProduct ensembl:ENSG00000174021
CCR8 GeneProduct ensembl:ENSG00000179934
CCL7 GeneProduct ensembl:ENSG00000108688
D-myo-Inositol 1,4,5-trisphosphate Metabolite kegg.compound:C01245
NFKB1 GeneProduct ensembl:ENSG00000109320
CHUK GeneProduct ensembl:ENSG00000213341
MAPK signaling pathway GeneProduct None
CXCL11 GeneProduct ensembl:ENSG00000169248
PTK2 GeneProduct ensembl:ENSG00000169398
CSK GeneProduct ensembl:ENSG00000103653
TIAM1 GeneProduct ensembl:ENSG00000156299
GNB3 GeneProduct ensembl:ENSG00000111664
3,5-Cyclic AMP Metabolite kegg.compound:C00575
PIK3R3 GeneProduct ensembl:ENSG00000117461
PLCB4 GeneProduct ensembl:ENSG00000101333
DOCK2 GeneProduct ensembl:ENSG00000134516
BRAF GeneProduct ensembl:ENSG00000157764
Cytokine-cytokine receptor interaction GeneProduct None
CCR1 GeneProduct ensembl:ENSG00000163823
CCL15 GeneProduct ensembl:ENSG00000275718
CX3CL1 GeneProduct ensembl:ENSG00000006210
LYN GeneProduct ensembl:ENSG00000254087
PRKACB GeneProduct ensembl:ENSG00000142875
ADCY5 GeneProduct ensembl:ENSG00000173175
CCR3 GeneProduct ensembl:ENSG00000183625
XCR1 GeneProduct ensembl:ENSG00000173578
PXN GeneProduct ensembl:ENSG00000089159
Ubiquitin mediated proteolysis GeneProduct None
SHC1 GeneProduct ensembl:ENSG00000160691
CCR10 GeneProduct ensembl:ENSG00000184451
Diacylglycerol Metabolite kegg.compound:C00165
GNG11 GeneProduct ensembl:ENSG00000127920
PF4 GeneProduct ensembl:ENSG00000163737
Gm12844 GeneProduct None
JAK3 GeneProduct ensembl:ENSG00000105639
PAK1 GeneProduct ensembl:ENSG00000149269
WASL GeneProduct ensembl:ENSG00000106299
CXCL5 GeneProduct ensembl:ENSG00000163735
BCAR1 GeneProduct ensembl:ENSG00000050820
GNG2 GeneProduct ensembl:ENSG00000186469
RASGRP2 GeneProduct ensembl:ENSG00000068831
STAT1 GeneProduct ensembl:ENSG00000115415
SHC3 GeneProduct ensembl:ENSG00000148082
PIK3CB GeneProduct ensembl:ENSG00000051382
CCL1 GeneProduct ensembl:ENSG00000108702
PIK3CD GeneProduct ensembl:ENSG00000171608
CCR7 GeneProduct ensembl:ENSG00000126353
Leukocyte transendothelial migration GeneProduct None
AC006486.9 GeneProduct ensembl:ENSG00000268643
CCR1 GeneProduct ensembl:ENSG00000163823
GRK2 GeneProduct ensembl:ENSG00000173020
VAV1 GeneProduct ensembl:ENSG00000141968
STAT2 GeneProduct ensembl:ENSG00000170581
CCL11 GeneProduct ensembl:ENSG00000172156
GRK6 GeneProduct ensembl:ENSG00000198055
PLCB3 GeneProduct ensembl:ENSG00000149782
CXCL9 GeneProduct ensembl:ENSG00000138755
SHC2 GeneProduct ensembl:ENSG00000129946
PIK3R5 GeneProduct ensembl:ENSG00000141506
CXCR6 GeneProduct ensembl:ENSG00000172215
CXCL14 GeneProduct ensembl:ENSG00000145824
Ccl8 GeneProduct None
CCL7 GeneProduct ensembl:ENSG00000108688
GNAI3 GeneProduct ensembl:ENSG00000065135
STAT5B GeneProduct ensembl:ENSG00000173757
CCR4 GeneProduct ensembl:ENSG00000183813
SHC4 GeneProduct ensembl:ENSG00000185634
GNG7 GeneProduct ensembl:ENSG00000176533
CXCR4 GeneProduct ensembl:ENSG00000121966
GNB1 GeneProduct ensembl:ENSG00000078369
MAPK1 GeneProduct ensembl:ENSG00000100030
PRKCZ GeneProduct ensembl:ENSG00000067606
Gm4356 GeneProduct None
ITK GeneProduct ensembl:ENSG00000113263
Regulation of actin cytoskeleton GeneProduct None
GRB2 GeneProduct ensembl:ENSG00000177885
PIK3CA GeneProduct ensembl:ENSG00000121879
ROCK1 GeneProduct ensembl:ENSG00000067900
PRKX GeneProduct ensembl:ENSG00000183943
ROCK2 GeneProduct ensembl:ENSG00000134318
CCL21 GeneProduct ensembl:ENSG00000137077
RELA GeneProduct ensembl:ENSG00000173039
SOS1 GeneProduct ensembl:ENSG00000115904
CXCR3 GeneProduct ensembl:ENSG00000186810
GNG12 GeneProduct ensembl:ENSG00000172380
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like GeneProduct None
GNG8 GeneProduct ensembl:ENSG00000167414
ADCY7 GeneProduct ensembl:ENSG00000121281
RAP1A GeneProduct ensembl:ENSG00000116473
KRAS GeneProduct ensembl:ENSG00000133703
XCL1 GeneProduct ensembl:ENSG00000143184
SOS2 GeneProduct ensembl:ENSG00000100485
PLCB2 GeneProduct ensembl:ENSG00000137841
AKT2 GeneProduct ensembl:ENSG00000105221
CCR2 GeneProduct ensembl:ENSG00000121807
CCR2 GeneProduct ensembl:ENSG00000121807
GNG5 GeneProduct ensembl:ENSG00000174021
CXCL12 GeneProduct ensembl:ENSG00000107562
CXCL3 GeneProduct ensembl:ENSG00000163734
NCF1 GeneProduct ensembl:ENSG00000158517
GNGT1 GeneProduct ensembl:ENSG00000127928
CXCL10 GeneProduct ensembl:ENSG00000169245
CCL24 GeneProduct ensembl:ENSG00000106178
GRK4 GeneProduct ensembl:ENSG00000125388
CCR6 GeneProduct ensembl:ENSG00000112486
CCL3 GeneProduct ensembl:ENSG00000277632
AKT3 GeneProduct ensembl:ENSG00000117020
CCR9 GeneProduct ensembl:ENSG00000173585
PLCB1 GeneProduct ensembl:ENSG00000182621
IKBKB GeneProduct ensembl:ENSG00000104365
CCL15 GeneProduct ensembl:ENSG00000275718
HRAS GeneProduct ensembl:ENSG00000174775
CCL28 GeneProduct ensembl:ENSG00000151882
PARD3 GeneProduct ensembl:ENSG00000148498
TIAM2 GeneProduct ensembl:ENSG00000146426
Ccl2 GeneProduct None
AKT1 GeneProduct ensembl:ENSG00000142208
CXCR2 GeneProduct ensembl:ENSG00000180871
Cxcl15 GeneProduct None
VAV3 GeneProduct ensembl:ENSG00000134215
NRAS GeneProduct ensembl:ENSG00000213281
FGR GeneProduct ensembl:ENSG00000000938
PTK2B GeneProduct ensembl:ENSG00000120899
GNB4 GeneProduct ensembl:ENSG00000114450
WAS GeneProduct ensembl:ENSG00000015285
CCL19 GeneProduct ensembl:ENSG00000172724
PRKCZ GeneProduct ensembl:ENSG00000067606
CCL25 GeneProduct ensembl:ENSG00000131142
MAPK3 GeneProduct ensembl:ENSG00000102882
ADCY3 GeneProduct ensembl:ENSG00000138031
CCL19 GeneProduct ensembl:ENSG00000172724
GRK1 GeneProduct ensembl:ENSG00000185974
ADCY4 GeneProduct ensembl:ENSG00000129467
ADCY8 GeneProduct ensembl:ENSG00000155897
CCL27 GeneProduct ensembl:ENSG00000213927
Gm3785 GeneProduct None
GNG13 GeneProduct ensembl:ENSG00000127588
Jak-STAT signaling pathway GeneProduct None
Rhoa GeneProduct None
ELMO1 GeneProduct ensembl:ENSG00000155849
c-C motif chemokine 12-like GeneProduct None
HCK GeneProduct ensembl:ENSG00000101336
CXCL13 GeneProduct ensembl:ENSG00000156234
GNAI1 GeneProduct ensembl:ENSG00000127955
NFKBIA GeneProduct ensembl:ENSG00000100906
STAT3 GeneProduct ensembl:ENSG00000168610
CXCR5 GeneProduct ensembl:ENSG00000160683
CCL26 GeneProduct ensembl:ENSG00000006606
ADCY9 GeneProduct ensembl:ENSG00000162104
MAP2K1 GeneProduct ensembl:ENSG00000169032
PRKCD GeneProduct ensembl:ENSG00000163932
GNB2 GeneProduct ensembl:ENSG00000172354
CCL5 GeneProduct ensembl:ENSG00000271503
NFKBIB GeneProduct ensembl:ENSG00000104825
GRK5 GeneProduct ensembl:ENSG00000198873
RAP1B GeneProduct ensembl:ENSG00000127314
ARRB1 GeneProduct ensembl:ENSG00000137486
CCL21 GeneProduct ensembl:ENSG00000137077
CXCL3 GeneProduct ensembl:ENSG00000163734
IKBKG GeneProduct ensembl:ENSG00000269335
ADCY1 GeneProduct ensembl:ENSG00000164742
CCL20 GeneProduct ensembl:ENSG00000115009
GNG3 GeneProduct ensembl:ENSG00000162188
CXCR2 GeneProduct ensembl:ENSG00000180871
ADCY6 GeneProduct ensembl:ENSG00000174233
PIK3CG GeneProduct ensembl:ENSG00000105851

References