Focal adhesion: PI3K-Akt-mTOR-signaling pathway (WP3932)

Cell-matrix adhesions play important roles in biological processes such as cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. Focal adhesions are structures formed at the cell-extracellular matrix contact points, consisting of bundles of actin filaments anchored to trans-membrane receptors of the integrin family through a complex of multiple proteins. In addition to participating in the structural link between membrane receptors and the actin cytoskeleton, focal adhesions also contain signaling molecules, such as protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent on the non-receptor tyrosine kinase activities of the FAK and src proteins and the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signaling events results in the reorganization of the actin cytoskeleton, which is essential for changes in cell shape and motility, and gene expression. Source: [https://www.genome.jp/dbget-bin/www_bget?pathway+map04510 KEGG] Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3932 CPTAC Assay Portal]
last edited

Authors

Khanspers, DeSl, and Eweitz

Cited In

Organism

Homo sapiens

Communities

CPTAC

Annotations

Pathway Ontology: mTOR signaling pathway cell adhesion signaling pathway signaling pathway

Participants

Label Type Compact Identifier
NOS2 GeneProduct ensembl:ENSG00000007171
NOS3 GeneProduct ensembl:ENSG00000164867
ITGA5 GeneProduct ensembl:ENSG00000161638
TSC1 GeneProduct ensembl:ENSG00000165699
LOC235580 GeneProduct None
PIK3CA GeneProduct ensembl:ENSG00000121879
CSF3 GeneProduct ensembl:ENSG00000108342
GRB2 GeneProduct ensembl:ENSG00000177885
JAK3 GeneProduct ensembl:ENSG00000105639
JAK2 GeneProduct ensembl:ENSG00000096968
EPO GeneProduct ensembl:ENSG00000130427
COL4A2 GeneProduct ensembl:ENSG00000134871
CHAD GeneProduct ensembl:ENSG00000136457
ITGB7 GeneProduct ensembl:ENSG00000139626
TNR GeneProduct ensembl:ENSG00000116147
STK11 GeneProduct ensembl:ENSG00000118046
COL11A2 GeneProduct ensembl:ENSG00000204248
LAMB3 GeneProduct ensembl:ENSG00000196878
IFNA7 GeneProduct ensembl:ENSG00000214042
CSH1 GeneProduct ensembl:ENSG00000136488
COMP GeneProduct ensembl:ENSG00000105664
ITGAE GeneProduct ensembl:ENSG00000083457
COL1A2 GeneProduct ensembl:ENSG00000164692
ITGB4 GeneProduct ensembl:ENSG00000132470
FN1 GeneProduct ensembl:ENSG00000115414
ITGAX GeneProduct ensembl:ENSG00000140678
ITGAD GeneProduct ensembl:ENSG00000156886
THBS2 GeneProduct ensembl:ENSG00000186340
IL3RA GeneProduct ensembl:ENSG00000185291
PIK3R1 GeneProduct ensembl:ENSG00000145675
COL5A1 GeneProduct ensembl:ENSG00000130635
AKT1 GeneProduct ensembl:ENSG00000142208
RELN GeneProduct ensembl:ENSG00000189056
PTK2 GeneProduct ensembl:ENSG00000169398
PIK3IP1 GeneProduct ensembl:ENSG00000100100
LAMC3 GeneProduct ensembl:ENSG00000050555
IL2RB GeneProduct ensembl:ENSG00000100385
IFNA7 GeneProduct ensembl:ENSG00000214042
LAMC2 GeneProduct ensembl:ENSG00000058085
IFNAR1 GeneProduct ensembl:ENSG00000142166
LAMB1 GeneProduct ensembl:ENSG00000091136
NO Metabolite chebi:29120
ITGA7 GeneProduct ensembl:ENSG00000135424
ITGB6 GeneProduct ensembl:ENSG00000115221
ITGA2B GeneProduct ensembl:ENSG00000005961
ITGA9 GeneProduct ensembl:ENSG00000144668
ITGA2 GeneProduct ensembl:ENSG00000164171
ITGB2 GeneProduct ensembl:ENSG00000160255
PIK3R2 GeneProduct ensembl:ENSG00000105647
COL4A6 GeneProduct ensembl:ENSG00000197565
PELO GeneProduct ensembl:ENSG00000152684
OSMR GeneProduct ensembl:ENSG00000145623
DDIT4 GeneProduct ensembl:ENSG00000168209
ITGA3 GeneProduct ensembl:ENSG00000005884
TNC GeneProduct ensembl:ENSG00000041982
COL5A2 GeneProduct ensembl:ENSG00000204262
LAMA4 GeneProduct ensembl:ENSG00000112769
ITGA8 GeneProduct ensembl:ENSG00000077943
COL4A1 GeneProduct ensembl:ENSG00000187498
LAMA3 GeneProduct ensembl:ENSG00000053747
LAMC1 GeneProduct ensembl:ENSG00000135862
LAMB2 GeneProduct ensembl:ENSG00000172037
THBS4 GeneProduct ensembl:ENSG00000113296
COL2A1 GeneProduct ensembl:ENSG00000139219
JAK1 GeneProduct ensembl:ENSG00000162434
PIK3CB GeneProduct ensembl:ENSG00000051382
THBS3 GeneProduct ensembl:ENSG00000169231
ITGA10 GeneProduct ensembl:ENSG00000143127
ITGAV GeneProduct ensembl:ENSG00000138448
PRLR GeneProduct ensembl:ENSG00000113494
IL7R GeneProduct ensembl:ENSG00000168685
ITGA6 GeneProduct ensembl:ENSG00000091409
LAMA5 GeneProduct ensembl:ENSG00000130702
IL6R GeneProduct ensembl:ENSG00000160712
ITGB1 GeneProduct ensembl:ENSG00000150093
IBSP GeneProduct ensembl:ENSG00000029559
Insulin Metabolite chebi:5931
Itgam GeneProduct None
COL6A2 GeneProduct ensembl:ENSG00000142173
VWF GeneProduct ensembl:ENSG00000110799
TNXB GeneProduct ensembl:ENSG00000168477
ITGB5 GeneProduct ensembl:ENSG00000082781
TNN GeneProduct ensembl:ENSG00000120332
SPP1 GeneProduct ensembl:ENSG00000118785
PTEN GeneProduct ensembl:ENSG00000171862
LAMA2 GeneProduct ensembl:ENSG00000196569
CSF3R GeneProduct ensembl:ENSG00000119535
IL2RA GeneProduct ensembl:ENSG00000134460
EPOR GeneProduct ensembl:ENSG00000187266
COL3A1 GeneProduct ensembl:ENSG00000168542
ITGAL GeneProduct ensembl:ENSG00000005844
IL4R GeneProduct ensembl:ENSG00000077238
LAMA1 GeneProduct ensembl:ENSG00000101680
SOS1 GeneProduct ensembl:ENSG00000115904
ITGB3 GeneProduct ensembl:ENSG00000259207
TSC2 GeneProduct ensembl:ENSG00000103197
PIK3CD GeneProduct ensembl:ENSG00000171608
ITGB8 GeneProduct ensembl:ENSG00000105855
VTN GeneProduct ensembl:ENSG00000109072
THBS1 GeneProduct ensembl:ENSG00000137801
AKT3 GeneProduct ensembl:ENSG00000117020
COL1A1 GeneProduct ensembl:ENSG00000108821
COL11A1 GeneProduct ensembl:ENSG00000060718
PIK3R4 GeneProduct ensembl:ENSG00000196455
COL5A3 GeneProduct ensembl:ENSG00000080573
IL2RG GeneProduct ensembl:ENSG00000147168
IFNA7 GeneProduct ensembl:ENSG00000214042
IFNAR2 GeneProduct ensembl:ENSG00000159110
COL4A4 GeneProduct ensembl:ENSG00000081052
AKT2 GeneProduct ensembl:ENSG00000105221
ITGA4 GeneProduct ensembl:ENSG00000115232
GHR GeneProduct ensembl:ENSG00000112964
ITGA11 GeneProduct ensembl:ENSG00000137809
PIK3R5 GeneProduct ensembl:ENSG00000141506
EFNA1 GeneProduct ensembl:ENSG00000169242
FGF1 GeneProduct ensembl:ENSG00000113578
FGF11 GeneProduct ensembl:ENSG00000161958
FGF10 GeneProduct ensembl:ENSG00000070193
EFNA2 GeneProduct ensembl:ENSG00000099617
EGF GeneProduct ensembl:ENSG00000138798
FGF12 GeneProduct ensembl:ENSG00000114279
CSF1 GeneProduct ensembl:ENSG00000184371
ANGPT4 GeneProduct ensembl:ENSG00000101280
ANGPT2 GeneProduct ensembl:ENSG00000091879
ANGPT1 GeneProduct ensembl:ENSG00000154188
VEGFA GeneProduct ensembl:ENSG00000112715
EFNA3 GeneProduct ensembl:ENSG00000143590
EFNA4 GeneProduct ensembl:ENSG00000243364
EFNA5 GeneProduct ensembl:ENSG00000184349
FGF14 GeneProduct ensembl:ENSG00000102466
FGF13 GeneProduct ensembl:ENSG00000129682
FGF19 GeneProduct ensembl:ENSG00000162344
FGF17 GeneProduct ensembl:ENSG00000158815
FGF18 GeneProduct ensembl:ENSG00000156427
FGF2 GeneProduct ensembl:ENSG00000138685
FGF3 GeneProduct ensembl:ENSG00000186895
FGF4 GeneProduct ensembl:ENSG00000075388
FGF6 GeneProduct ensembl:ENSG00000111241
FGF7 GeneProduct ensembl:ENSG00000140285
FGF8 GeneProduct ensembl:ENSG00000107831
FGF9 GeneProduct ensembl:ENSG00000102678
VEGFD GeneProduct ensembl:ENSG00000165197
HGF GeneProduct ensembl:ENSG00000019991
IGF1 GeneProduct ensembl:ENSG00000017427
INS GeneProduct ensembl:ENSG00000254647
INS GeneProduct ensembl:ENSG00000254647
KITLG GeneProduct ensembl:ENSG00000049130
Kik1b4 GeneProduct None
Kik1b4 GeneProduct None
VEGFC GeneProduct ensembl:ENSG00000150630
VEGFB GeneProduct ensembl:ENSG00000173511
PDGFB GeneProduct ensembl:ENSG00000100311
PGF GeneProduct ensembl:ENSG00000119630
PDGFA GeneProduct ensembl:ENSG00000197461
NGF GeneProduct ensembl:ENSG00000134259
PDGFC GeneProduct ensembl:ENSG00000145431
FGF21 GeneProduct ensembl:ENSG00000105550
Fgf23 GeneProduct None
FGF22 GeneProduct ensembl:ENSG00000070388
PDGFD GeneProduct ensembl:ENSG00000170962
FGF20 GeneProduct ensembl:ENSG00000078579
FGF16 GeneProduct ensembl:ENSG00000196468
FGFR2 GeneProduct ensembl:ENSG00000066468
KDR GeneProduct ensembl:ENSG00000128052
INSR GeneProduct ensembl:ENSG00000171105
FGFR3 GeneProduct ensembl:ENSG00000068078
IGF1R GeneProduct ensembl:ENSG00000140443
KIT GeneProduct ensembl:ENSG00000157404
FGFR1 GeneProduct ensembl:ENSG00000077782
EPHA2 GeneProduct ensembl:ENSG00000142627
EGFR GeneProduct ensembl:ENSG00000146648
CSF1R GeneProduct ensembl:ENSG00000182578
FGFR4 GeneProduct ensembl:ENSG00000160867
FLT1 GeneProduct ensembl:ENSG00000102755
FLT4 GeneProduct ensembl:ENSG00000037280
NGFR GeneProduct ensembl:ENSG00000064300
MET GeneProduct ensembl:ENSG00000105976
PDGFRA GeneProduct ensembl:ENSG00000134853
PDGFRB GeneProduct ensembl:ENSG00000113721
TEK GeneProduct ensembl:ENSG00000120156
AKT1S1 GeneProduct ensembl:ENSG00000204673
IFNA7 GeneProduct ensembl:ENSG00000214042
IFNA7 GeneProduct ensembl:ENSG00000214042
IFNA7 GeneProduct ensembl:ENSG00000214042
IFNA7 GeneProduct ensembl:ENSG00000214042
IFNA7 GeneProduct ensembl:ENSG00000214042
IFNA7 GeneProduct ensembl:ENSG00000214042
IFNB1 GeneProduct ensembl:ENSG00000171855
IL2 GeneProduct ensembl:ENSG00000109471
OSM GeneProduct ensembl:ENSG00000099985
PRL GeneProduct ensembl:ENSG00000172179
IFNA7 GeneProduct ensembl:ENSG00000214042
Gm12597 GeneProduct None
Ifna12 GeneProduct None
IFNA7 GeneProduct ensembl:ENSG00000214042
CHRM1 GeneProduct ensembl:ENSG00000168539
LPAR1 GeneProduct ensembl:ENSG00000198121
F2R GeneProduct ensembl:ENSG00000181104
CHRM2 GeneProduct ensembl:ENSG00000181072
LPAR5 GeneProduct ensembl:ENSG00000184574
LPAR2 GeneProduct ensembl:ENSG00000064547
LPAR3 GeneProduct ensembl:ENSG00000171517
LPAR6 GeneProduct ensembl:ENSG00000139679
LPAR4 GeneProduct ensembl:ENSG00000147145
GNG5 GeneProduct ensembl:ENSG00000174021
GNB2 GeneProduct ensembl:ENSG00000172354
GNB1 GeneProduct ensembl:ENSG00000078369
Gm5741 GeneProduct None
GNB4 GeneProduct ensembl:ENSG00000114450
GNGT1 GeneProduct ensembl:ENSG00000127928
GNG10 GeneProduct ensembl:ENSG00000242616
GNG12 GeneProduct ensembl:ENSG00000172380
GNB3 GeneProduct ensembl:ENSG00000111664
GNG2 GeneProduct ensembl:ENSG00000186469
GNG3 GeneProduct ensembl:ENSG00000162188
GNG4 GeneProduct ensembl:ENSG00000168243
GNG5 GeneProduct ensembl:ENSG00000174021
GNG7 GeneProduct ensembl:ENSG00000176533
GNG8 GeneProduct ensembl:ENSG00000167414
GNGT2 GeneProduct ensembl:ENSG00000167083
GNG13 GeneProduct ensembl:ENSG00000127588
GNG11 GeneProduct ensembl:ENSG00000127920
PIK3CG GeneProduct ensembl:ENSG00000105851
NRAS GeneProduct ensembl:ENSG00000213281
KRAS GeneProduct ensembl:ENSG00000133703
HRAS GeneProduct ensembl:ENSG00000174775
STRADA GeneProduct ensembl:ENSG00000266173
CAB39 GeneProduct ensembl:ENSG00000135932
CAB39L GeneProduct ensembl:ENSG00000102547
PRKAA1 GeneProduct ensembl:ENSG00000132356
PRKAA2 GeneProduct ensembl:ENSG00000162409
MLST8 GeneProduct ensembl:ENSG00000167965
RHEB GeneProduct ensembl:ENSG00000106615
MTOR GeneProduct ensembl:ENSG00000198793
RPTOR GeneProduct ensembl:ENSG00000141564
HIF1A GeneProduct ensembl:ENSG00000100644
ULK1 GeneProduct ensembl:ENSG00000177169
CRTC2 GeneProduct ensembl:ENSG00000160741
CDC37 GeneProduct ensembl:ENSG00000105401
HSP90AB1 GeneProduct ensembl:ENSG00000096384
PHLPP1 GeneProduct ensembl:ENSG00000081913
TCL1A GeneProduct ensembl:ENSG00000100721
PDPK1 GeneProduct ensembl:ENSG00000140992
Gm2436 GeneProduct None
PPP2CB GeneProduct ensembl:ENSG00000104695
PPP2CA GeneProduct ensembl:ENSG00000113575
Gm2446 GeneProduct None
PPP2R5D GeneProduct ensembl:ENSG00000112640
PPP2R5B GeneProduct ensembl:ENSG00000068971
PPP2R2B GeneProduct ensembl:ENSG00000156475
PPP2R1B GeneProduct ensembl:ENSG00000137713
Ppp2r3d GeneProduct None
PPP2R3A GeneProduct ensembl:ENSG00000073711
PPP2R5C GeneProduct ensembl:ENSG00000078304
PPP2R5E GeneProduct ensembl:ENSG00000154001
PPP2R2C GeneProduct ensembl:ENSG00000074211
PPP2R1A GeneProduct ensembl:ENSG00000105568
PPP2R2D GeneProduct ensembl:ENSG00000175470
PPP2R5A GeneProduct ensembl:ENSG00000066027
PPP2R3C GeneProduct ensembl:ENSG00000092020
HSP90AA1 GeneProduct ensembl:ENSG00000080824
HSP90B1 GeneProduct ensembl:ENSG00000166598
PHLPP2 GeneProduct ensembl:ENSG00000040199
Mtcp1 GeneProduct None
TCL1B GeneProduct ensembl:ENSG00000213231
TCL1B GeneProduct ensembl:ENSG00000213231
RAF1 GeneProduct ensembl:ENSG00000132155
MAP2K2 GeneProduct ensembl:ENSG00000126934
MAP2K1 GeneProduct ensembl:ENSG00000169032
MAPK1 GeneProduct ensembl:ENSG00000100030
MAPK3 GeneProduct ensembl:ENSG00000102882
GSK3B GeneProduct ensembl:ENSG00000082701
FOXO3 GeneProduct ensembl:ENSG00000118689
FOXO1 GeneProduct ensembl:ENSG00000150907
IKBKB GeneProduct ensembl:ENSG00000104365
BAD GeneProduct ensembl:ENSG00000002330
CASP9 GeneProduct ensembl:ENSG00000132906
MDM2 GeneProduct ensembl:ENSG00000135679
IKBKG GeneProduct ensembl:ENSG00000269335
CDKN1B GeneProduct ensembl:ENSG00000111276
CDKN1A GeneProduct ensembl:ENSG00000124762
ATF2 GeneProduct ensembl:ENSG00000115966
CREB3 GeneProduct ensembl:ENSG00000107175
CREB1 GeneProduct ensembl:ENSG00000118260
ATF4 GeneProduct ensembl:ENSG00000128272
CREB3L2 GeneProduct ensembl:ENSG00000182158
CREB3L3 GeneProduct ensembl:ENSG00000060566
ATF6B GeneProduct ensembl:ENSG00000213676
CREB3L1 GeneProduct ensembl:ENSG00000157613
CREB3L4 GeneProduct ensembl:ENSG00000143578
CREB5 GeneProduct ensembl:ENSG00000146592
TBC1D1 GeneProduct ensembl:ENSG00000065882
RAB8A GeneProduct ensembl:ENSG00000167461
RAB2A GeneProduct ensembl:ENSG00000104388
RAB10 GeneProduct ensembl:ENSG00000084733
RAB11B GeneProduct ensembl:ENSG00000185236
RAB14 GeneProduct ensembl:ENSG00000119396
SLC2A4 GeneProduct ensembl:ENSG00000181856
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SLC2A3 GeneProduct ensembl:ENSG00000059804
SLC2A2 GeneProduct ensembl:ENSG00000163581
PPARGC1A GeneProduct ensembl:ENSG00000109819
GYS1 GeneProduct ensembl:ENSG00000104812
GYS2 GeneProduct ensembl:ENSG00000111713
PFKFB2 GeneProduct ensembl:ENSG00000123836
PFKFB1 GeneProduct ensembl:ENSG00000158571
PFKFB3 GeneProduct ensembl:ENSG00000170525
PFKFB4 GeneProduct ensembl:ENSG00000114268
LIPE GeneProduct ensembl:ENSG00000079435
SREBF1 GeneProduct ensembl:ENSG00000072310
FOXA1 GeneProduct ensembl:ENSG00000129514
ACACA GeneProduct ensembl:ENSG00000278540
ELAVL1 GeneProduct ensembl:ENSG00000066044
NOS1 GeneProduct ensembl:ENSG00000089250
EPAS1 GeneProduct ensembl:ENSG00000116016
HIF3A GeneProduct ensembl:ENSG00000124440
RPS6KB2 GeneProduct ensembl:ENSG00000175634
EIF4EBP1 GeneProduct ensembl:ENSG00000187840
EIF4B GeneProduct ensembl:ENSG00000063046
RPS6KB1 GeneProduct ensembl:ENSG00000108443
RPS6 GeneProduct ensembl:ENSG00000137154
EIF4E GeneProduct ensembl:ENSG00000151247
EIF4E2 GeneProduct ensembl:ENSG00000135930
EIF4E1B GeneProduct ensembl:ENSG00000175766
PIK3C2B GeneProduct ensembl:ENSG00000133056
PIK3C2A GeneProduct ensembl:ENSG00000011405
Pik3c2g GeneProduct None
IRS1 GeneProduct ensembl:ENSG00000169047
IRS4 GeneProduct ensembl:ENSG00000133124
Irs3 GeneProduct None
IRS2 GeneProduct ensembl:ENSG00000185950
Insr GeneProduct None
Ins1 GeneProduct None
Ins2 GeneProduct None

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