Leptin and adiponectin (WP3934)

Proposed mechanism by which leptin and adiponectin stimulate fatty acid oxidation. Adapted from fig 1 in [http://www.ncbi.nlm.nih.gov/pubmed/16497175 Dyck et al.]. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3934 CPTAC Assay Portal]
last edited


Khanspers and MaintBot

Cited In


Homo sapiens



Disease Ontology: glucose metabolism disease glucose metabolism disease

Pathway Ontology: leptin system pathway adiponectin signaling pathway adiponectin signaling pathway leptin system pathway


Label Type Compact Identifier
ADIPOR1 GeneProduct ensembl:ENSG00000159346
Fatty acid Metabolite chebi:35366
PRKAA1 GeneProduct ensembl:ENSG00000132356
PRKAB1 GeneProduct ensembl:ENSG00000111725
LEP GeneProduct ensembl:ENSG00000174697
Fatty acid Metabolite chebi:35366
ADIPOR2 GeneProduct ensembl:ENSG00000006831
ACACA GeneProduct ensembl:ENSG00000278540
Acetyl-CoA Metabolite chebi:15351
PRKAG1 GeneProduct ensembl:ENSG00000181929
LEPR GeneProduct ensembl:ENSG00000116678
CPT1A GeneProduct ensembl:ENSG00000110090
ADIPOQ GeneProduct ensembl:ENSG00000181092
Malonyl-CoA Metabolite chebi:15531


  1. Dyck DJ, Heigenhauser GJF, Bruce CR. The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity. Acta Physiol (Oxf). 2006 Jan;186(1):5–16. PubMed Europe PMC Scholia