Microglia pathogen phagocytosis pathway (WP3937)

Pathogens are recognized by complement C1q or immunoglobulin (IgG) that bind to microglia complement receptors (e.g., ITGAM/ITGB2) or Fc-receptors (e.g., FCGR1) that signal via the immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptor molecules TYROBP or FCER1G, respectively. Alternatively, pathogens are directly recognized by classical innate immune receptors (e.g., TREM2) that require the interaction with TYROBP for further signaling. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3937 CPTAC Assay Portal]
last edited

Authors

Khanspers, DeSl, MaintBot, Eweitz, Ddigles, and AlexanderPico

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: Alzheimer's disease pathway innate immune response pathway Alzheimer's disease pathway innate immune response pathway

Cell Type Ontology: microglial cell microglial cell

Participants

Label Type Compact Identifier
Oxygen Metabolite hmdb:HMDB0001377
Pik3 GeneProduct None
IgG GeneProduct None
HCK GeneProduct ensembl:ENSG00000101336
C1QA GeneProduct ensembl:ENSG00000173372
TYROBP GeneProduct ensembl:ENSG00000011600
SYK GeneProduct ensembl:ENSG00000165025
PIK3R1 GeneProduct ensembl:ENSG00000145675
SIGLEC7 GeneProduct ensembl:ENSG00000168995
TREM1 GeneProduct ensembl:ENSG00000124731
PIP2 Metabolite wikidata:Q27088398
FCER1G GeneProduct ensembl:ENSG00000158869
FCGR1A GeneProduct ensembl:ENSG00000150337
ITGAM GeneProduct ensembl:ENSG00000169896
TREM2 GeneProduct ensembl:ENSG00000095970
TREM3 GeneProduct None
ITGB2 GeneProduct ensembl:ENSG00000160255
LYN GeneProduct ensembl:ENSG00000254087
PTPN6 GeneProduct ensembl:ENSG00000111679
PLCG2 GeneProduct ensembl:ENSG00000197943
LAT GeneProduct ensembl:ENSG00000213658
RAC1 GeneProduct ensembl:ENSG00000136238
RAC2 GeneProduct ensembl:ENSG00000128340
RAC3 GeneProduct ensembl:ENSG00000169750
VAV1 GeneProduct ensembl:ENSG00000141968
VAV2 GeneProduct ensembl:ENSG00000160293
VAV3 GeneProduct ensembl:ENSG00000134215
NCKAP1L GeneProduct ensembl:ENSG00000123338
ARPC1B GeneProduct ensembl:ENSG00000130429
NCF4 GeneProduct ensembl:ENSG00000100365
NCF2 GeneProduct ensembl:ENSG00000116701
NCF1 GeneProduct ensembl:ENSG00000158517
CYBB GeneProduct ensembl:ENSG00000165168
CYBA GeneProduct ensembl:ENSG00000051523
NCF1 GeneProduct ensembl:ENSG00000158517
NCF4 GeneProduct ensembl:ENSG00000100365
NCF2 GeneProduct ensembl:ENSG00000116701
RAC1 GeneProduct ensembl:ENSG00000136238
RAC2 GeneProduct ensembl:ENSG00000128340
RAC3 GeneProduct ensembl:ENSG00000169750
CYBB GeneProduct ensembl:ENSG00000165168
CYBA GeneProduct ensembl:ENSG00000051523
C1QB GeneProduct ensembl:ENSG00000173369
C1QC GeneProduct ensembl:ENSG00000159189
PIP3 Metabolite hmdb:HMDB0004249
PIK3CG GeneProduct ensembl:ENSG00000105851
PIK3CA GeneProduct ensembl:ENSG00000121879
PIK3CD GeneProduct ensembl:ENSG00000171608
PIK3CB GeneProduct ensembl:ENSG00000051382
PIK3R2 GeneProduct ensembl:ENSG00000105647
PIK3C3 GeneProduct ensembl:ENSG00000078142
PIK3C2A GeneProduct ensembl:ENSG00000011405
PIK3R6 GeneProduct ensembl:ENSG00000276231
PIK3R3 GeneProduct ensembl:ENSG00000117461

References

  1. Zhang B, Gaiteri C, Bodea L-G, Wang Z, McElwee J, Podtelezhnikov AA, et al. Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer’s disease. Cell. 2013 Apr 25;153(3):707–20. PubMed Europe PMC Scholia