PPAR signaling pathway (WP3942)

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3942 CPTAC Assay Portal]
last edited

Authors

Khanspers, DeSl, and MaintBot

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: signaling pathway peroxisome proliferator-activated receptor signaling pathway peroxisome proliferator-activated receptor signaling pathway

Cell Type Ontology: cell of skeletal muscle white fat cell

Participants

Label Type Compact Identifier
ACAA1 GeneProduct ensembl:ENSG00000060971
PPARD GeneProduct ensembl:ENSG00000112033
PPARG GeneProduct ensembl:ENSG00000132170
Ubc GeneProduct None
PCK2 GeneProduct ensembl:ENSG00000100889
CYP4A11 GeneProduct ensembl:ENSG00000187048
CYP8B1 GeneProduct ensembl:ENSG00000180432
UCP1 GeneProduct ensembl:ENSG00000109424
SLC27A1 GeneProduct ensembl:ENSG00000130304
HMGCS2 GeneProduct ensembl:ENSG00000134240
CYP4A11 GeneProduct ensembl:ENSG00000187048
RXRB GeneProduct ensembl:ENSG00000204231
AQP7 GeneProduct ensembl:ENSG00000165269
SCD GeneProduct ensembl:ENSG00000099194
ACOX1 GeneProduct ensembl:ENSG00000161533
CYP4A11 GeneProduct ensembl:ENSG00000187048
Adipocytokine signaling pathway GeneProduct None
SCD GeneProduct ensembl:ENSG00000099194
SCD GeneProduct ensembl:ENSG00000099194
NR1H3 GeneProduct ensembl:ENSG00000025434
RXRA GeneProduct ensembl:ENSG00000186350
ACSBG2 GeneProduct ensembl:ENSG00000130377
FABP1 GeneProduct ensembl:ENSG00000163586
CYP4A11 GeneProduct ensembl:ENSG00000187048
RXRG GeneProduct ensembl:ENSG00000143171
RXRB GeneProduct ensembl:ENSG00000204231
ACSL6 GeneProduct ensembl:ENSG00000164398
ANGPTL4 GeneProduct ensembl:ENSG00000167772
CYP27A1 GeneProduct ensembl:ENSG00000135929
ACSL3 GeneProduct ensembl:ENSG00000123983
FABP7 GeneProduct ensembl:ENSG00000164434
ACADM GeneProduct ensembl:ENSG00000117054
CPT1B GeneProduct ensembl:ENSG00000205560
CPT1C GeneProduct ensembl:ENSG00000169169
RXRA GeneProduct ensembl:ENSG00000186350
CYP4A11 GeneProduct ensembl:ENSG00000187048
FABP3 GeneProduct ensembl:ENSG00000121769
CYP4A11 GeneProduct ensembl:ENSG00000187048
FABP2 GeneProduct ensembl:ENSG00000145384
ACSL4 GeneProduct ensembl:ENSG00000068366
DBI GeneProduct ensembl:ENSG00000155368
SLC27A2 GeneProduct ensembl:ENSG00000140284
SLC27A4 GeneProduct ensembl:ENSG00000167114
APOA2 GeneProduct ensembl:ENSG00000158874
CD36 GeneProduct ensembl:ENSG00000135218
SLC27A1 GeneProduct ensembl:ENSG00000130304
FABP1 GeneProduct ensembl:ENSG00000163586
ME1 GeneProduct ensembl:ENSG00000065833
ADIPOQ GeneProduct ensembl:ENSG00000181092
APOC3 GeneProduct ensembl:ENSG00000110245
ACSL5 GeneProduct ensembl:ENSG00000197142
FABP4 GeneProduct ensembl:ENSG00000170323
PPARA GeneProduct ensembl:ENSG00000186951
FADS2 GeneProduct ensembl:ENSG00000134824
RXRG GeneProduct ensembl:ENSG00000143171
CYP7A1 GeneProduct ensembl:ENSG00000167910
PLTP GeneProduct ensembl:ENSG00000100979
GK3P GeneProduct ensembl:ENSG00000229894
Primary bile acid biosynthesis GeneProduct None
PLIN1 GeneProduct ensembl:ENSG00000166819
SLC27A5 GeneProduct ensembl:ENSG00000083807
ACOX3 GeneProduct ensembl:ENSG00000087008
APOA5 GeneProduct ensembl:ENSG00000110243
ACOX2 GeneProduct ensembl:ENSG00000168306
PCK1 GeneProduct ensembl:ENSG00000124253
CPT2 GeneProduct ensembl:ENSG00000157184
ACSL1 GeneProduct ensembl:ENSG00000151726
FABP6 GeneProduct ensembl:ENSG00000170231
RXRB GeneProduct ensembl:ENSG00000204231
MMP1 GeneProduct ensembl:ENSG00000196611
OLR1 GeneProduct ensembl:ENSG00000173391
SLC27A4 GeneProduct ensembl:ENSG00000167114
CYP4A11 GeneProduct ensembl:ENSG00000187048
CD36 GeneProduct ensembl:ENSG00000135218
MMP1 GeneProduct ensembl:ENSG00000196611
SLC27A6 GeneProduct ensembl:ENSG00000113396
CYP4A11 GeneProduct ensembl:ENSG00000187048
ACSBG1 GeneProduct ensembl:ENSG00000103740
unsaturated fatty acids Metabolite chebi:27208
SCP2 GeneProduct ensembl:ENSG00000116171
SCD GeneProduct ensembl:ENSG00000099194
cytochrome P450 4A14-like GeneProduct None
LPL GeneProduct ensembl:ENSG00000175445
Glycerophospholipid metabolism GeneProduct None
ILK GeneProduct ensembl:ENSG00000166333
APOA1 GeneProduct ensembl:ENSG00000118137
Synthesis and degradation of ketone bodies GeneProduct None
GK2 GeneProduct ensembl:ENSG00000196475
FABP3 GeneProduct ensembl:ENSG00000121769
Fatty acid metabolism GeneProduct None
RXRG GeneProduct ensembl:ENSG00000143171
CPT1A GeneProduct ensembl:ENSG00000110090
RXRA GeneProduct ensembl:ENSG00000186350
SORBS1 GeneProduct ensembl:ENSG00000095637
FABP4 GeneProduct ensembl:ENSG00000170323
FABP5 GeneProduct ensembl:ENSG00000164687
EHHADH GeneProduct ensembl:ENSG00000113790
PDPK1 GeneProduct ensembl:ENSG00000140992
ACADL GeneProduct ensembl:ENSG00000115361
ACAA1 GeneProduct ensembl:ENSG00000060971
saturated fatty acids Metabolite chebi:26607
eicosanoid Metabolite chebi:23899
ciprofibrate Metabolite chebi:50867
NSAIDs Metabolite chebi:35475
9-cis-Retinoic acid Metabolite hmdb:HMDB0002369
unsaturated fatty acids Metabolite chebi:27208
9-cis-Retinoic acid Metabolite hmdb:HMDB0002369
unsaturated fatty acids Metabolite chebi:27208
eicosanoid Metabolite chebi:23899
NSAIDs Metabolite chebi:35475
Thiazolidine derivative Metabolite chebi:35622
9-cis-Retinoic acid Metabolite hmdb:HMDB0002369

References

  1. Fujii H. PPARs-mediated intracellular signal transduction. Nihon Rinsho. 2005 Apr;63(4):565–71. PubMed Europe PMC Scholia