TYROBP causal network in microglia (WP3945)

The direct and indirect causal inputs upstream and downstream of Tyrobp in microglial cells. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3945 CPTAC Assay Portal]
last edited

Authors

Khanspers, AlexanderPico, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Cell Type Ontology: microglial cell microglial cell

Disease Ontology: Alzheimer's disease

Pathway Ontology: innate immune response pathway Alzheimer's disease pathway innate immune response pathway

Participants

Label Type Compact Identifier
GIMAP2 GeneProduct ensembl:ENSG00000106560
TCIRG1 GeneProduct ensembl:ENSG00000110719
DPYD GeneProduct ensembl:ENSG00000188641
SAMSN1 GeneProduct ensembl:ENSG00000155307
IL13RA1 GeneProduct ensembl:ENSG00000131724
GPX1 GeneProduct ensembl:ENSG00000233276
LGALS9C GeneProduct ensembl:ENSG00000171916
ITGAM GeneProduct ensembl:ENSG00000169896
BIN2 GeneProduct ensembl:ENSG00000110934
PPP1R18 GeneProduct ensembl:ENSG00000146112
IGSF6 GeneProduct ensembl:ENSG00000140749
PYCARD GeneProduct ensembl:ENSG00000103490
NCKAP1L GeneProduct ensembl:ENSG00000123338
SLC1A5 GeneProduct ensembl:ENSG00000105281
FKBP15 GeneProduct ensembl:ENSG00000119321
NPC2 GeneProduct ensembl:ENSG00000119655
CXCL16 GeneProduct ensembl:ENSG00000161921
TYROBP GeneProduct ensembl:ENSG00000011600
HLX GeneProduct ensembl:ENSG00000136630
CD4 GeneProduct ensembl:ENSG00000010610
ABCC4 GeneProduct ensembl:ENSG00000125257
SLC7A7 GeneProduct ensembl:ENSG00000155465
RBM47 GeneProduct ensembl:ENSG00000163694
APBB1IP GeneProduct ensembl:ENSG00000077420
C1QC GeneProduct ensembl:ENSG00000159189
ITGB2 GeneProduct ensembl:ENSG00000160255
ADAP2 GeneProduct ensembl:ENSG00000184060
TMEM106A GeneProduct ensembl:ENSG00000184988
CAPG GeneProduct ensembl:ENSG00000042493
STAT5A GeneProduct ensembl:ENSG00000126561
ELF4 GeneProduct ensembl:ENSG00000102034
RPS6KA1 GeneProduct ensembl:ENSG00000117676
SPP1 GeneProduct ensembl:ENSG00000118785
CREB3L2 GeneProduct ensembl:ENSG00000182158
ZFP36L2 GeneProduct ensembl:ENSG00000152518
RUNX3 GeneProduct ensembl:ENSG00000020633
PLEK GeneProduct ensembl:ENSG00000115956
NRROS GeneProduct ensembl:ENSG00000174004
LYL1 GeneProduct ensembl:ENSG00000104903
LOXL3 GeneProduct ensembl:ENSG00000115318
C3 GeneProduct ensembl:ENSG00000125730
NCF2 GeneProduct ensembl:ENSG00000116701
GAPT GeneProduct ensembl:ENSG00000175857
CD37 GeneProduct ensembl:ENSG00000104894
TGFBR1 GeneProduct ensembl:ENSG00000106799
GAL3ST4 GeneProduct ensembl:ENSG00000197093
CD84 GeneProduct ensembl:ENSG00000066294
ITGAX GeneProduct ensembl:ENSG00000140678
RNASE6 GeneProduct ensembl:ENSG00000169413
HCLS1 GeneProduct ensembl:ENSG00000180353
IL10RA GeneProduct ensembl:ENSG00000110324
SH2B3 GeneProduct ensembl:ENSG00000111252
CYTL1 GeneProduct ensembl:ENSG00000170891
TNFRSF1B GeneProduct ensembl:ENSG00000028137
RGS1 GeneProduct ensembl:ENSG00000090104
IL18 GeneProduct ensembl:ENSG00000150782
KCNE3 GeneProduct ensembl:ENSG00000175538
SFT2D2 GeneProduct ensembl:ENSG00000213064
MAF GeneProduct ensembl:ENSG00000178573
LHFPL2 GeneProduct ensembl:ENSG00000145685

References

  1. Zhang B, Gaiteri C, Bodea L-G, Wang Z, McElwee J, Podtelezhnikov AA, et al. Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer’s disease. Cell. 2013 Apr 25;153(3):707–20. PubMed Europe PMC Scholia