Liver steatosis adverse outcome pathway (WP4010)

This liver steatosis AOP starts from the top with different molecular initiating events going down towards liver steatosis. The black nodes are Key Events and green nodes are molecular pathways. Adverse outcome pathway liver steatosis; the accumulation of lipids in hepatocytes, caused either by over-nutrition, visceral obesity, metabolic syndrome, or environmental toxins. Liver steatosis can be divided into three main categories: alcoholic liver disease (ALD), non-alcoholic liver disease (NAFLD), and toxicant-associated liver disease (TAFLD).[https://pubmed.ncbi.nlm.nih.gov/28210688/ Review on liver steatosis]
last edited

Authors

JJvdHeijden, AlexanderPico, Marvin M2, Jkearns445, ChesdeWindt, Eweitz, and Finterly

Cited In

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Organism

Homo sapiens

Communities

Adverse Outcome Pathways

Annotations

Cell Type Ontology: hepatocyte

Disease Ontology: fatty liver disease

Participants

Label Type Compact Identifier
KE66: Activation, ChREBP Event aop.events:66
KE228: demethylation, PPARg promoter Event aop.events:228
KE291: Accumulation, Triglyceride Event aop.events:291
KE466: Up Regulation, LDLR (low density lipoprotein receptor) Event aop.events:466
Lipid Metabolism Pathway Pathway wikipathways:WP3965
KE258: Activation, SCD-1 Event aop.events:258
KE116: Activation, FAS Event aop.events:116
NRF2 pathway Pathway wikipathways:WP2884
Mitochondrial LC-Fatty Acid Beta-Oxidation Pathway wikipathways:WP368
KE860: Decreased, Mitochondrial Fatty Acid Beta Oxidation Event aop.events:860
Liver X Receptor Pathway Pathway wikipathways:WP2874
Farnesoid X Receptor Pathway Pathway wikipathways:WP2879
KE54 Up Regulation, CD36 Event aop.events:54
KE474: Down Regulation, HMGCS2 Event aop.events:474
KE345: Liver steatosis Event aop.events:345
KE245: Activation, PXR/SXR Event aop.events:245
KE227: Activation, PPARĪ± Event aop.events:227
PPAR Alpha Pathway Pathway wikipathways:WP2878
KE232: Decreased, PPAR-beta activation Event aop.events:232
KE264: Activation, SREBP-1c Event aop.events:264
KE471: Inhibition, FoxA2 Event aop.events:471
KE115: Increase, FA Influx Event aop.events:115
Aryl Hydrocarbon Receptor Netpath Pathway wikipathways:WP2586
KE472: Down Regulation, CPT1A Event aop.events:472
Branched-chain amino acid catabolism Pathway wikipathways:WP3556
Metabolic pathway of LDL Pathway wikipathways:WP4522
KE18: Activation, AhR Event aop.events:18
KE1214: Altered gene expression specific to CAR activation, Hepatocytes Event aop.events:1214
Angiopoietin Like Protein 8 Regulatory Pathway Pathway wikipathways:WP3915
Cholesterol metabolism Pathway wikipathways:WP4718
KE167: Activation, LXR Event aop.events:167
Pregnane X Receptor pathway Pathway wikipathways:WP2876
KE10106: Fatty Acid Lysis Event aop.events:10106
Constitutive Androstane Receptor Pathway Pathway wikipathways:WP2875
KE140: Decreased, HSD17B10 expression Event aop.events:140
AMP-activated Protein Kinase (AMPK) Signaling Pathway wikipathways:WP1403
KE89: Synthesis, De Novo FA Event aop.events:89
Sterol Regulatory Element-Binding Proteins (SREBP) signalling Pathway wikipathways:WP1982
KE478: Activation, NRF2 Event aop.events:478
KE479: Activation, NR1H4 Event aop.events:479
Fatty acid transporters Pathway wikipathways:WP5061
Fatty Acid Biosynthesis Pathway wikipathways:WP357
PPAR Gamma Pathway Pathway wikipathways:WP5071
PPAR Beta/Delta pathway Pathway wikipathways:WP5073
Foxa2 Pathway Pathway wikipathways:WP5066

References