Liver steatosis adverse outcome pathway (WP4010)

This liver steatosis AOP starts from the top with different molecular initiating events going down towards liver steatosis. The black nodes are Key Events and green nodes are molecular pathways. Adverse outcome pathway liver steatosis; the accumulation of lipids in hepatocytes, caused either by over-nutrition, visceral obesity, metabolic syndrome, or environmental toxins. Liver steatosis can be divided into three main categories: alcoholic liver disease (ALD), non-alcoholic liver disease (NAFLD), and toxicant-associated liver disease (TAFLD).[ Review on liver steatosis]
last edited


JJvdHeijden, AlexanderPico, Marvin M2, Jkearns445, ChesdeWindt, Eweitz, and Finterly

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Homo sapiens


Adverse Outcome Pathways


Cell Type Ontology: hepatocyte

Disease Ontology: fatty liver disease


Label Type Compact Identifier
KE66: Activation, ChREBP Event
KE228: demethylation, PPARg promoter Event
KE291: Accumulation, Triglyceride Event
KE466: Up Regulation, LDLR (low density lipoprotein receptor) Event
Lipid Metabolism Pathway Pathway wikipathways:WP3965
KE258: Activation, SCD-1 Event
KE116: Activation, FAS Event
NRF2 pathway Pathway wikipathways:WP2884
Mitochondrial LC-Fatty Acid Beta-Oxidation Pathway wikipathways:WP368
KE860: Decreased, Mitochondrial Fatty Acid Beta Oxidation Event
Liver X Receptor Pathway Pathway wikipathways:WP2874
Farnesoid X Receptor Pathway Pathway wikipathways:WP2879
KE54 Up Regulation, CD36 Event
KE474: Down Regulation, HMGCS2 Event
KE345: Liver steatosis Event
KE245: Activation, PXR/SXR Event
KE227: Activation, PPARĪ± Event
PPAR Alpha Pathway Pathway wikipathways:WP2878
KE232: Decreased, PPAR-beta activation Event
KE264: Activation, SREBP-1c Event
KE471: Inhibition, FoxA2 Event
KE115: Increase, FA Influx Event
Aryl Hydrocarbon Receptor Netpath Pathway wikipathways:WP2586
KE472: Down Regulation, CPT1A Event
Branched-chain amino acid catabolism Pathway wikipathways:WP3556
Metabolic pathway of LDL Pathway wikipathways:WP4522
KE18: Activation, AhR Event
KE1214: Altered gene expression specific to CAR activation, Hepatocytes Event
Angiopoietin Like Protein 8 Regulatory Pathway Pathway wikipathways:WP3915
Cholesterol metabolism Pathway wikipathways:WP4718
KE167: Activation, LXR Event
Pregnane X Receptor pathway Pathway wikipathways:WP2876
KE10106: Fatty Acid Lysis Event
Constitutive Androstane Receptor Pathway Pathway wikipathways:WP2875
KE140: Decreased, HSD17B10 expression Event
AMP-activated Protein Kinase (AMPK) Signaling Pathway wikipathways:WP1403
KE89: Synthesis, De Novo FA Event
Sterol Regulatory Element-Binding Proteins (SREBP) signalling Pathway wikipathways:WP1982
KE478: Activation, NRF2 Event
KE479: Activation, NR1H4 Event
Fatty acid transporters Pathway wikipathways:WP5061
Fatty Acid Biosynthesis Pathway wikipathways:WP357
PPAR Gamma Pathway Pathway wikipathways:WP5071
PPAR Beta/Delta pathway Pathway wikipathways:WP5073
Foxa2 Pathway Pathway wikipathways:WP5066