Wnt signaling pathway (WP403)

Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. Source: [http://www.genome.jp/kegg/pathway/hsa/hsa04310.html KEGG].
last edited

Authors

M.Lieberman, MaintBot, Thomas, Ddigles, Cizar, Ariutta, Mkutmon, and Eweitz

Cited In

Organism

Mus musculus

Communities

Annotations

Pathway Ontology: Wnt signaling pathway

Participants

Label Type Compact Identifier
Dvl3 GeneProduct ncbigene:13544
Rhoa GeneProduct ncbigene:11848
Rac1 GeneProduct ncbigene:19353
Plau GeneProduct ncbigene:18792
Prkcb GeneProduct ncbigene:18751
Prkch GeneProduct ncbigene:18755
Frat1 GeneProduct ncbigene:14296
Gsk3b GeneProduct ncbigene:56637
Apc GeneProduct ncbigene:11789
Wnt3a GeneProduct ncbigene:22416
Fzd3 GeneProduct ncbigene:14365
Mapk9 GeneProduct ncbigene:26420
Csnk1e GeneProduct ncbigene:27373
Ccnd1 GeneProduct ncbigene:12443
Ldlr GeneProduct ncbigene:16835
Fzd8 GeneProduct ncbigene:14370
Prkd1 GeneProduct ncbigene:18760
Wnt7a GeneProduct ncbigene:22421
Wnt11 GeneProduct ncbigene:22411
Wnt1 GeneProduct ncbigene:22408
Prkca GeneProduct ncbigene:18750
Jun GeneProduct ncbigene:16476
Fzd10 GeneProduct ncbigene:93897
Fzd7 GeneProduct ncbigene:14369
Ppp2r5c GeneProduct ncbigene:26931
Wnt5b GeneProduct ncbigene:22419
Ctnnb1 GeneProduct ncbigene:12387
Wnt2 GeneProduct ncbigene:22413
Prkce GeneProduct ncbigene:18754
Wnt2b GeneProduct ncbigene:22414
Sfrp4 GeneProduct ncbigene:20379
Prkcc GeneProduct ncbigene:18752
Pafah1b1 GeneProduct ncbigene:18472
Dvl2 GeneProduct ncbigene:13543
Wnt6 GeneProduct ncbigene:22420
Ccnd3 GeneProduct ncbigene:12445
Wnt5a GeneProduct ncbigene:22418
Fzd1 GeneProduct ncbigene:14362
Wnt16 GeneProduct ncbigene:93735
Fzd6 GeneProduct ncbigene:14368
Wnt4 GeneProduct ncbigene:22417
Ppp2r5e GeneProduct ncbigene:26932
Wnt3 GeneProduct ncbigene:22415
Axin1 GeneProduct ncbigene:12005
Wnt10b GeneProduct ncbigene:22410
Prkcq GeneProduct ncbigene:18761
Fzd5 GeneProduct ncbigene:14367
Wnt7b GeneProduct ncbigene:22422
Dvl1 GeneProduct ncbigene:13542
Prkci GeneProduct ncbigene:18759
Wnt10a GeneProduct ncbigene:22409
Fosl1 GeneProduct ncbigene:14283
Mapk10 GeneProduct ncbigene:26414
Apoptosis Pathway wikipathways:1254
Myc GeneProduct ncbigene:17869
Prkcz GeneProduct ncbigene:18762
Ccnd2 GeneProduct ncbigene:12444
Fzd9 GeneProduct ncbigene:14371
Fbxw2 GeneProduct ncbigene:30050
Prkcd GeneProduct ncbigene:18753
TCF-1/LEF GeneProduct None
Wnt16 GeneProduct ncbigene:93735
Fzd2 GeneProduct ncbigene:57265

References

  1. Nusse R. Wnt signaling in disease and in development. Cell Res. 2005 Jan;15(1):28–32. PubMed Europe PMC Scholia