Kit receptor signaling pathway (WP407)

Kit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets among others. Binding of Kit receptor to stem cell factor leads to an intracellular cascade of events that includes activation of PI 3-kinase, Src family kinases and PLC gamma. Activating mutations in the Kit receptor are associated with several human malignancies include leukemias, gastrointestinal stromal tumors and mastocytomas. Source: NetPath
last edited


A.Pandey, MaintBot, AlexanderPico, Ddigles, and Eweitz

Cited In


Mus musculus



Pathway Ontology: Stem Cell Factor signaling pathway


Label Type Compact Identifier
Stat1 GeneProduct ncbigene:20846
Cish GeneProduct ncbigene:12700
Kitl GeneProduct ncbigene:17311
Dok1 GeneProduct ncbigene:13448
Btk GeneProduct ncbigene:12229
Vav1 GeneProduct ncbigene:22324
Stat5a GeneProduct ncbigene:20850
Jak2 GeneProduct ncbigene:16452
Mpdz GeneProduct ncbigene:17475
Ptpn6 GeneProduct ncbigene:15170
Rps6ka1 GeneProduct ncbigene:20111
Prkcb GeneProduct ncbigene:18751
Grb7 GeneProduct ncbigene:14786
Socs5 GeneProduct ncbigene:56468
Sh2b2 GeneProduct ncbigene:23921
Map2k1 GeneProduct ncbigene:26395
Vav2 GeneProduct ncbigene:22325
Dok1 GeneProduct ncbigene:13448
Abl1 GeneProduct ncbigene:11350
Pik3r1 GeneProduct ncbigene:18708
Src GeneProduct ncbigene:20779
Raf1 GeneProduct ncbigene:110157
Kit GeneProduct ncbigene:16590
Ptpru GeneProduct ncbigene:19273
Inpp5d GeneProduct ncbigene:16331
Fgr GeneProduct ncbigene:14191
Yes1 GeneProduct ncbigene:22612
Stat5b GeneProduct ncbigene:20851
Akt1 GeneProduct ncbigene:11651
Kitl GeneProduct ncbigene:17311
Socs4 GeneProduct ncbigene:67296
Grap GeneProduct ncbigene:71520
Matk GeneProduct ncbigene:17179
Hck GeneProduct ncbigene:15162
Pik3cg GeneProduct ncbigene:30955
Plcg1 GeneProduct ncbigene:18803
Crkl GeneProduct ncbigene:12929
Kit GeneProduct ncbigene:16590
Tnfrsf10b GeneProduct ncbigene:21933
Ep300 GeneProduct ncbigene:328572
Rasa1 GeneProduct ncbigene:218397
Socs1 GeneProduct ncbigene:12703
Ptpn11 GeneProduct ncbigene:19247
Fes GeneProduct ncbigene:14159
CSF2RB GeneProduct ncbigene:12983
Socs6 GeneProduct ncbigene:54607
Spred1 GeneProduct ncbigene:114715
Spred2 GeneProduct ncbigene:114716
Cltc GeneProduct ncbigene:67300
Mapk1 GeneProduct ncbigene:26413
Grb2 GeneProduct ncbigene:14784
Bad GeneProduct ncbigene:12015
Lyn GeneProduct ncbigene:17096
Cblb GeneProduct ncbigene:208650
Pik3r2 GeneProduct ncbigene:18709
Epor GeneProduct ncbigene:13857
Fyn GeneProduct ncbigene:14360
Grb10 GeneProduct ncbigene:14783
Prkca GeneProduct ncbigene:18750
Crk GeneProduct ncbigene:12928
Hras1 GeneProduct ncbigene:15461
Mitf GeneProduct ncbigene:17342
Plce1 GeneProduct ncbigene:74055
Sos1 GeneProduct ncbigene:20662
Shc1 GeneProduct ncbigene:20416
Stat3 GeneProduct ncbigene:20848
Tec GeneProduct ncbigene:21682
Stap1 GeneProduct ncbigene:56792
Sh3kbp1 GeneProduct ncbigene:58194
Cbl GeneProduct ncbigene:12402