Exercise-induced circadian regulation (WP410)

Human genes regulated in the diurnal comparison with orthologues that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regulated (P < 0.05) hSkM genes identified in the diurnal comparison (0800 h and 2000 h) were subjected to an additional statistical filter of absolute fold change > 20% (n = 239) and linked to mouse circadianally regulated orthologues. This pathway represents the resultant 44 putative hSkM circadianally regulated genes; L, promoter for the light-responsive element; E, E-box (Clock/Bmal1 promoter). Orthologue information is denoted to the left of the gene boxes: mHrts and mLvrs, mouse orthologue was circadianally regulated as described (Storch 2002) in mouse heart or liver, respectively; mLvrp and mSCNp, mouse orthologue was diurnally regulated as described (Panda 2002) in mouse liver or SCN, respectively. Based on [https://www.ncbi.nlm.nih.gov/pubmed/14519196 Zambon et al, Genome Biol. 2003;4(10):R61]. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP410 CPTAC Assay Portal]
last edited


A.C.Zambon, MaintBot, Thomas, AlexanderPico, Khanspers, MartijnVanIersel, Mkutmon, AMTan, and Eweitz

Cited In


Homo sapiens



Pathway Ontology: regulatory pathway

Cell Type Ontology: cell of skeletal muscle


Label Type Compact Identifier
ZFR GeneProduct ncbigene:51663
NCKAP1 GeneProduct ncbigene:10787
CLDN5 GeneProduct ncbigene:7122
CRY1 GeneProduct ncbigene:1407
HLA-DMA GeneProduct ncbigene:3108
GENX-3414 GeneProduct ncbigene:8987
PPP2CB GeneProduct ncbigene:5516
GFRA1 GeneProduct ncbigene:2674
CEBPB GeneProduct ncbigene:1051
HERPUD1 GeneProduct ncbigene:9709
HSPA8 GeneProduct ncbigene:3312
CAST GeneProduct ncbigene:26059
QKI GeneProduct ncbigene:9444
TUBB3 GeneProduct ncbigene:10381
VAPA GeneProduct ncbigene:9218
TOB1 GeneProduct ncbigene:10140
PER1 GeneProduct ncbigene:5187
DAZAP2 GeneProduct ncbigene:9802
MYF6 GeneProduct ncbigene:4618
IDI1 GeneProduct ncbigene:3422
KLF9 GeneProduct ncbigene:687
GSTP1 GeneProduct ncbigene:2950
CRY2 GeneProduct ncbigene:1408
BTG1 GeneProduct ncbigene:694
GSTM3 GeneProduct ncbigene:2947
PPP1R3C GeneProduct ncbigene:5507
NCOA4 GeneProduct ncbigene:8031
CLOCK GeneProduct ncbigene:9575
SUMO1 GeneProduct ncbigene:7341
RBPMS GeneProduct ncbigene:11030
PURA GeneProduct ncbigene:5813
PIGF GeneProduct ncbigene:5281
NR1D2 GeneProduct ncbigene:9975
PSMA4 GeneProduct ncbigene:5685
ARNTL GeneProduct ncbigene:406
UGP2 GeneProduct ncbigene:7360
SUMO3 GeneProduct ncbigene:6612
MAP3K7IP2 GeneProduct ncbigene:23118
SF3A3 GeneProduct ncbigene:10946
EIF4G2 GeneProduct ncbigene:1982
DNAJA1 GeneProduct ncbigene:3301
PER2 GeneProduct ncbigene:8864
HIST1H2BN GeneProduct ncbigene:8341
UCP3 GeneProduct ncbigene:7352
CBX3 GeneProduct ncbigene:11335
G0S2 GeneProduct ncbigene:50486
ETV6 GeneProduct ncbigene:2120
AZIN1 GeneProduct ncbigene:51582
PER1 GeneProduct ncbigene:5187
PER2 GeneProduct ncbigene:8864
CRY1 GeneProduct ncbigene:1407
CRY2 GeneProduct ncbigene:1408
CRY2 GeneProduct ncbigene:1408
CRY1 GeneProduct ncbigene:1407
PER2 GeneProduct ncbigene:8864
PER1 GeneProduct ncbigene:5187


  1. Storch K-F, Lipan O, Leykin I, Viswanathan N, Davis FC, Wong WH, et al. Extensive and divergent circadian gene expression in liver and heart. Nature. 2002 May 2;417(6884):78–83. PubMed Europe PMC Scholia
  2. Panda S, Antoch MP, Miller BH, Su AI, Schook AB, Straume M, et al. Coordinated transcription of key pathways in the mouse by the circadian clock. Cell. 2002 May 3;109(3):307–20. PubMed Europe PMC Scholia
  3. Zambon AC, McDearmon EL, Salomonis N, Vranizan KM, Johansen KL, Adey D, et al. Time- and exercise-dependent gene regulation in human skeletal muscle. Genome Biol. 2003;4(10):R61. PubMed Europe PMC Scholia