G1 to S cell cycle control (WP413)

In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=69615&
last edited

Authors

A.C.Zambon, Nsalomonis, MaintBot, Khanspers, Christine Chichester, and Mkutmon

Cited In

Organism

Mus musculus

Communities

Annotations

Pathway Ontology: G1/S DNA damage checkpoint pathway

Participants

Label Type Compact Identifier
Ccne1 GeneProduct ncbigene:12447
Ccnd3 GeneProduct ncbigene:12445
E2f3 GeneProduct ncbigene:13557
Wee1 GeneProduct ncbigene:22390
Cdkn1a GeneProduct ncbigene:12575
Cdk7 GeneProduct ncbigene:12572
Prim1 GeneProduct ncbigene:19075
CyclinD GeneProduct None
Orc6l GeneProduct ncbigene:56452
Pola2 GeneProduct ncbigene:18969
Ccne2 GeneProduct ncbigene:12448
Cdkn2a GeneProduct ncbigene:12578
Tfdp2 GeneProduct ncbigene:211586
Ccnb1-rs1 GeneProduct ncbigene:12429
Ccnd2 GeneProduct ncbigene:12444
Mnat1 GeneProduct ncbigene:17420
Ccnh GeneProduct ncbigene:66671
Rb GeneProduct None
E2f5 GeneProduct ncbigene:13559
E2f1 GeneProduct ncbigene:13555
Cdk7 GeneProduct ncbigene:12572
Pole GeneProduct ncbigene:18973
Orc4l GeneProduct ncbigene:26428
Cdk6 GeneProduct ncbigene:12571
Cdk6 GeneProduct ncbigene:12571
Gadd45a GeneProduct ncbigene:13197
E2f4 GeneProduct ncbigene:104394
Mdm2 GeneProduct ncbigene:17246
Pole2 GeneProduct ncbigene:18974
Myc GeneProduct ncbigene:17869
Cdc45l GeneProduct ncbigene:12544
Cdkn2c GeneProduct ncbigene:12580
Rpa2 GeneProduct ncbigene:19891
Cdc2a GeneProduct ncbigene:12534
Pcna GeneProduct ncbigene:18538
Orc2l GeneProduct ncbigene:18393
Cdk4 GeneProduct ncbigene:12567
dp1 GeneProduct None
Cdk GeneProduct None
Mcm4 GeneProduct ncbigene:17217
Cdk GeneProduct None
Orc3l GeneProduct ncbigene:50793
Rbl1 GeneProduct ncbigene:19650
Orc1l GeneProduct ncbigene:18392
Mcm6 GeneProduct ncbigene:17219
Tfdp1 GeneProduct ncbigene:21781
Cdkn1c GeneProduct ncbigene:12577
Cdc25a GeneProduct ncbigene:12530
Rpa1 GeneProduct ncbigene:68275
Orc5l GeneProduct ncbigene:26429
Cdkn1b GeneProduct ncbigene:12576
Mcm5 GeneProduct ncbigene:17218
Cdk4 GeneProduct ncbigene:12567
Cdc2a GeneProduct ncbigene:12534
Trp53 GeneProduct ncbigene:22059
Cdkn2d GeneProduct ncbigene:12581
E2f GeneProduct None
Cdk GeneProduct None
p53 GeneProduct None
Cdk GeneProduct None
Pkmyt1 GeneProduct ncbigene:268930
Ccng2 GeneProduct ncbigene:12452
Prim2 GeneProduct ncbigene:19076
Rb GeneProduct None
E2f2 GeneProduct ncbigene:242705
Mcm7 GeneProduct ncbigene:17220
Ccna1 GeneProduct ncbigene:12427
Rpa3 GeneProduct ncbigene:68240
Cdkn2b GeneProduct ncbigene:12579
CyclinE GeneProduct None
Mcm2 GeneProduct ncbigene:17216
CyclinE GeneProduct None
E2f GeneProduct None
Cdk2 GeneProduct ncbigene:12566
E2f6 GeneProduct ncbigene:50496
Ccnd1 GeneProduct ncbigene:12443
Rb1 GeneProduct ncbigene:19645
CyclinD GeneProduct None
Atm GeneProduct ncbigene:11920
Mcm3 GeneProduct ncbigene:17215

References

  1. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA. GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure. J Invest Dermatol. 2002 Jul;119(1):22–6. PubMed Europe PMC Scholia