Macrophage markers (WP4146)

Overview of macrophage markers. Macrophages are cells within the tissues that originate from specific white blood cells called monocytes. Based on [ this list] and tissue-specific gene expression from [ GeneAtlas]. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]
last edited


Mkutmon, Khanspers, and AlexanderPico

Cited In


Homo sapiens



Cell Type Ontology: macrophage


Label Type Compact Identifier
CD83 GeneProduct ensembl:ENSG00000112149
CD14 GeneProduct ensembl:ENSG00000170458
CD68 GeneProduct ensembl:ENSG00000129226
F3 GeneProduct ensembl:ENSG00000117525
CD163 GeneProduct ensembl:ENSG00000177575
CD86 GeneProduct ensembl:ENSG00000114013
CD74 GeneProduct ensembl:ENSG00000019582
Cd52 GeneProduct None
RAC2 GeneProduct ensembl:ENSG00000128340
LYZ GeneProduct ensembl:ENSG00000090382


  1. Mahnke K, Becher E, Ricciardi-Castagnoli P, Luger TA, Schwarz T, Grabbe S. CD14 is expressed by subsets of murine dendritic cells and upregulated by lipopolysaccharide. Adv Exp Med Biol. 1997;417:145–59. PubMed Europe PMC Scholia
  2. Aperlo C, Sevilla L, Guerin S, Pognonec P, Boulukos KE. Synergistic effects of colony-stimulating factor 1 and leukemia inhibitory factor in inducing early myeloid cell differentiation. Cell Growth Differ. 1998 Nov;9(11):929–37. PubMed Europe PMC Scholia
  3. Fonseca JE, Edwards JCW, Blades S, Goulding NJ. Macrophage subpopulations in rheumatoid synovium: reduced CD163 expression in CD4+ T lymphocyte-rich microenvironments. Arthritis Rheum. 2002 May;46(5):1210–6. PubMed Europe PMC Scholia
  4. Brettschneider J, Ecker D, Bitsch A, Bahner D, Bogumil T, Dressel A, et al. The macrophage activity marker sCD14 is increased in patients with multiple sclerosis and upregulated by interferon beta-1b. J Neuroimmunol. 2002 Dec;133(1–2):193–7. PubMed Europe PMC Scholia
  5. Lau SK, Chu PG, Weiss LM. CD163: a specific marker of macrophages in paraffin-embedded tissue samples. Am J Clin Pathol. 2004 Nov;122(5):794–801. PubMed Europe PMC Scholia
  6. Hiraoka A, Horiike N, Akbar SMF, Michitaka K, Matsuyama T, Onji M. Expression of CD163 in the liver of patients with viral hepatitis. Pathol Res Pract. 2005;201(5):379–84. PubMed Europe PMC Scholia
  7. Töröcsik D, Bárdos H, Nagy L, Adány R. Identification of factor XIII-A as a marker of alternative macrophage activation. Cell Mol Life Sci. 2005 Sep;62(18):2132–9. PubMed Europe PMC Scholia
  8. Kunz-Schughart LA, Weber A, Rehli M, Gottfried E, Brockhoff G, Krause SW, et al. The “classical” macrophage marker CD68 is strongly expressed in primary human fibroblasts. Verh Dtsch Ges Pathol. 2003;87:215–23. PubMed Europe PMC Scholia