White fat cell differentiation (WP4149)

The transcription factors involved in white fat cell differentiation are shown, specifically their pattern of activity from the preadipocyte to the adipocyte (fat cells) stage. Adipose tissue, composed of white and brown adipose tissue, is composed of adipocytes. This pathway is primarily studied to understand factors that contribute to obesity and diabetes. Transcriptional and hormonal regulators of adipocyte formation are indicated.
last edited

Authors

Mkutmon and MaintBot

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: signaling pathway

Cell Type Ontology: white fat cell

Participants

Label Type Compact Identifier
WNT10B GeneProduct ensembl:ENSG00000169884
EBF1 GeneProduct ensembl:ENSG00000164330
SREBF1 GeneProduct ensembl:ENSG00000072310
CEBPA GeneProduct ensembl:ENSG00000245848
CEBPB GeneProduct ensembl:ENSG00000172216
MECOM GeneProduct ensembl:ENSG00000085276
FBS Metabolite None
RORA GeneProduct ensembl:ENSG00000069667
DDIT3 GeneProduct ensembl:ENSG00000175197
CREB1 GeneProduct ensembl:ENSG00000118260
IRF3 GeneProduct ensembl:ENSG00000126456
STAT5B GeneProduct ensembl:ENSG00000173757
KLF15 GeneProduct ensembl:ENSG00000163884
KLF5 GeneProduct ensembl:ENSG00000102554
GATA2 GeneProduct ensembl:ENSG00000179348
TCF7L1 GeneProduct ensembl:ENSG00000152284
ZNF423 GeneProduct ensembl:ENSG00000102935
EGR2 GeneProduct ensembl:ENSG00000122877
GATA3 GeneProduct ensembl:ENSG00000107485
NR2F2 GeneProduct ensembl:ENSG00000185551
PPARG GeneProduct ensembl:ENSG00000132170
NR1H3 GeneProduct ensembl:ENSG00000025434
CEBPD GeneProduct ensembl:ENSG00000221869
CTNNA1 GeneProduct ensembl:ENSG00000044115
KLF4 GeneProduct ensembl:ENSG00000136826
cAMP Metabolite chebi:17489
RARA GeneProduct ensembl:ENSG00000131759
FOXO1 GeneProduct ensembl:ENSG00000150907
STAT5A GeneProduct ensembl:ENSG00000126561
TLE3 GeneProduct ensembl:ENSG00000140332
INS GeneProduct ensembl:ENSG00000254647
Glucocorticoids Metabolite chebi:24261
NR3C1 GeneProduct ensembl:ENSG00000113580
IRF4 GeneProduct ensembl:ENSG00000137265
KLF2 GeneProduct ensembl:ENSG00000127528

References

  1. Rosen ED, Spiegelman BM. Molecular regulation of adipogenesis. Annu Rev Cell Dev Biol. 2000;16:145–71. PubMed Europe PMC Scholia
  2. Rosen ED, MacDougald OA. Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol. 2006 Dec;7(12):885–96. PubMed Europe PMC Scholia
  3. Villanueva CJ, Waki H, Godio C, Nielsen R, Chou W-L, Vargas L, et al. TLE3 is a dual-function transcriptional coregulator of adipogenesis. Cell Metab. 2011 Apr 6;13(4):413–27. PubMed Europe PMC Scholia
  4. Siersbæk R, Nielsen R, Mandrup S. Transcriptional networks and chromatin remodeling controlling adipogenesis. Trends Endocrinol Metab. 2012 Feb;23(2):56–64. PubMed Europe PMC Scholia
  5. Gubelmann C, Schwalie PC, Raghav SK, Röder E, Delessa T, Kiehlmann E, et al. Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network. Elife. 2014 Aug 27;3:e03346. PubMed Europe PMC Scholia