Wnt signaling in kidney disease (WP4150)

This pathway is modeled after Figure 5 of the article "Glomerulocystic kidney disease" (Bissler, et al. 2010). The gene product Wnt signals two different paths titled canonical and non-canonical. The non-canonical path is mediated by the membrane bound protein Disheveled (Dvl) which then controls the planar cell Polarity. The canonical path on the other hand is mediated by the cytoplasmic protein Disheveled (Dvl) and then is effected through b-catenin transcription. The complex of Nphp2 and Nphp3 seem to help facilitate the process by controlling the Wnt signaling. Bergmann, et al. (2008) showed that Nphp3 deficiency in Xenopus resulted to planar cell polarity defects. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP4150 CPTAC Assay Portal].
last edited

Authors

Martina Summer-Kutmon , Kristina Hanspers , Maintenance bot , and Eric Weitz

Cited In

Organism

Homo sapiens

Communities

Diseases Renal Genomics Pathways

Annotations

Disease Ontology: kidney disease

Pathway Ontology: signaling pathway Wnt signaling pathway Wnt signaling, the planar cell polarity pathway

Participants

Label Type Compact Identifier
Calcium Metabolite hmdb:HMDB0000464
NPHP3-ACAD11 GeneProduct ensembl:ENSG00000274810
RHOA GeneProduct ensembl:ENSG00000067560
CTNNB1 GeneProduct ensembl:ENSG00000168036
INVS GeneProduct ensembl:ENSG00000119509
LRP5 GeneProduct ensembl:ENSG00000162337
LRP6 GeneProduct ensembl:ENSG00000070018
WNT1 GeneProduct ensembl:ENSG00000125084
WNT10A GeneProduct ensembl:ENSG00000135925
WNT10B GeneProduct ensembl:ENSG00000169884
WNT7A GeneProduct ensembl:ENSG00000154764
WNT16 GeneProduct ensembl:ENSG00000002745
WNT6 GeneProduct ensembl:ENSG00000115596
WNT5A GeneProduct ensembl:ENSG00000114251
WNT2B GeneProduct ensembl:ENSG00000134245
WNT11 GeneProduct ensembl:ENSG00000085741
WNT4 GeneProduct ensembl:ENSG00000162552
WNT3A GeneProduct ensembl:ENSG00000154342
WNT5B GeneProduct ensembl:ENSG00000111186
WNT9B GeneProduct ensembl:ENSG00000158955
WNT2 GeneProduct ensembl:ENSG00000105989
WNT3 GeneProduct ensembl:ENSG00000108379
WNT7B GeneProduct ensembl:ENSG00000188064
FZD1 GeneProduct ensembl:ENSG00000157240
FZD8 GeneProduct ensembl:ENSG00000177283
FZD4 GeneProduct ensembl:ENSG00000174804
FZD2 GeneProduct ensembl:ENSG00000180340
FZD7 GeneProduct ensembl:ENSG00000155760
FZD9 GeneProduct ensembl:ENSG00000188763
FZD5 GeneProduct ensembl:ENSG00000163251
FZD6 GeneProduct ensembl:ENSG00000164930
FZD3 GeneProduct ensembl:ENSG00000104290
FZD1 GeneProduct ensembl:ENSG00000157240
FZD8 GeneProduct ensembl:ENSG00000177283
FZD4 GeneProduct ensembl:ENSG00000174804
FZD2 GeneProduct ensembl:ENSG00000180340
FZD7 GeneProduct ensembl:ENSG00000155760
FZD9 GeneProduct ensembl:ENSG00000188763
FZD5 GeneProduct ensembl:ENSG00000163251
FZD6 GeneProduct ensembl:ENSG00000164930
FZD3 GeneProduct ensembl:ENSG00000104290
DVL2 GeneProduct ensembl:ENSG00000004975
DVL3 GeneProduct ensembl:ENSG00000161202
DVL1 GeneProduct ensembl:ENSG00000107404
MAPK9 GeneProduct ensembl:ENSG00000050748
MAPK10 GeneProduct ensembl:ENSG00000109339
MAPK8 GeneProduct ensembl:ENSG00000107643
DVL2 GeneProduct ensembl:ENSG00000004975
DVL3 GeneProduct ensembl:ENSG00000161202
DVL1 GeneProduct ensembl:ENSG00000107404

References

  1. Bergmann C, Fliegauf M, Brüchle NO, Frank V, Olbrich H, Kirschner J, et al. Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia. Am J Hum Genet. 2008 Apr;82(4):959–70. PubMed Europe PMC Scholia
  2. Bissler JJ, Siroky BJ, Yin H. Glomerulocystic kidney disease. Pediatr Nephrol. 2010 Oct;25(10):2049–56; quiz 2056–9. PubMed Europe PMC Scholia