Immune response to tuberculosis (WP4197)

This pathway is published in "The human immune response to tuberculosis and its treatment: a view from the blood" (PMID: 25703554). Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP4197 CPTAC Assay Portal].
last edited

Authors

Andra, Egonw, Khanspers, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Disease Ontology: tuberculosis

Participants

Label Type Compact Identifier
IRF9 GeneProduct ensembl:ENSG00000213928
IFNG Protein None
PSMB8 GeneProduct ensembl:ENSG00000204264
OAS1 GeneProduct ensembl:ENSG00000089127
MX1 GeneProduct ensembl:ENSG00000157601
IRF1 GeneProduct ensembl:ENSG00000125347
SOCS1 GeneProduct ensembl:ENSG00000185338
GIP2 GeneProduct None
STAT1 GeneProduct ensembl:ENSG00000115415
PIAS1 GeneProduct ensembl:ENSG00000033800
STAT1 GeneProduct ensembl:ENSG00000115415
IFITM1 GeneProduct ensembl:ENSG00000185885
IRF9 GeneProduct ensembl:ENSG00000213928
PSMB8 GeneProduct ensembl:ENSG00000204264
IFNGR1 GeneProduct ensembl:ENSG00000027697
IRF9 GeneProduct ensembl:ENSG00000213928
PTPN2 GeneProduct ensembl:ENSG00000175354
TAP1 GeneProduct ensembl:ENSG00000168394
DRIP150 Complex uniprot:O60244
IFI35 GeneProduct ensembl:ENSG00000068079
IFIT1 GeneProduct ensembl:ENSG00000185745
IFITM1 GeneProduct ensembl:ENSG00000185885
IFI35 GeneProduct ensembl:ENSG00000068079
TYK2 GeneProduct ensembl:ENSG00000105397
JAK1 GeneProduct ensembl:ENSG00000162434
IFIT3 GeneProduct ensembl:ENSG00000119917
STAT1 GeneProduct ensembl:ENSG00000115415
STAT1 GeneProduct ensembl:ENSG00000115415
STAT1 GeneProduct ensembl:ENSG00000115415
STAT1 GeneProduct ensembl:ENSG00000115415
STAT2 GeneProduct ensembl:ENSG00000170581
STAT1 GeneProduct ensembl:ENSG00000115415
STAT2 GeneProduct ensembl:ENSG00000170581
GIP3 GeneProduct None
JAK2 GeneProduct ensembl:ENSG00000096968
PTPN2 GeneProduct ensembl:ENSG00000175354
JAK1 GeneProduct ensembl:ENSG00000162434
JAK2 GeneProduct ensembl:ENSG00000096968
JAK1 GeneProduct ensembl:ENSG00000162434
STAT1 GeneProduct ensembl:ENSG00000115415
STAT2 GeneProduct ensembl:ENSG00000170581
PTPN2 GeneProduct ensembl:ENSG00000175354
IFNGR2 GeneProduct ensembl:ENSG00000159128
IFNGR1 GeneProduct ensembl:ENSG00000027697
IFNGR2 GeneProduct ensembl:ENSG00000159128
IFNAR1 GeneProduct ensembl:ENSG00000142166
IFNAR2 GeneProduct ensembl:ENSG00000159110
IFNa/IFNb Protein None

References

  1. Berry MPR, Graham CM, McNab FW, Xu Z, Bloch SAA, Oni T, et al. An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Nature. 2010 Aug 19;466(7309):973–7. PubMed Europe PMC Scholia
  2. Cliff JM, Lee J-S, Constantinou N, Cho J-E, Clark TG, Ronacher K, et al. Distinct phases of blood gene expression pattern through tuberculosis treatment reflect modulation of the humoral immune response. J Infect Dis. 2013 Jan 1;207(1):18–29. PubMed Europe PMC Scholia
  3. Bloom CI, Graham CM, Berry MPR, Rozakeas F, Redford PS, Wang Y, et al. Transcriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, pneumonias and lung cancers. PLoS One. 2013 Aug 5;8(8):e70630. PubMed Europe PMC Scholia
  4. Cliff JM, Kaufmann SHE, McShane H, van Helden P, O’Garra A. The human immune response to tuberculosis and its treatment: a view from the blood. Immunol Rev. 2015 Mar;264(1):88–102. PubMed Europe PMC Scholia