Hedgehog signaling pathway (WP4249)

In the absence of the Hh ligand, the receptor PTCH (Patched) acts to prevent high expression and activity of SMO (Smoothened). When Hh is bound, the repression of SMO is relieved which leads to activation of the GLI transcription factors: activators Gli1 and Gli2 and repressor Gli3. Activated GLI then controls the transcription of hedgehog target genes. Pathway adapted from [http://www.genome.jp/kegg-bin/show_pathway?hsa04340 KEGG]
last edited

Authors

Khanspers, AlexanderPico, and Eweitz

Cited In

Organism

Homo sapiens

Communities

CPTAC

Annotations

Pathway Ontology: Hedgehog signaling pathway signaling pathway pertinent to development signaling pathway

Participants

Label Type Compact Identifier
CSNK1G2 GeneProduct ensembl:ENSG00000133275
GRK2 GeneProduct ensembl:ENSG00000173020
FBXL17 GeneProduct ensembl:ENSG00000145743
GAS1 GeneProduct ensembl:ENSG00000180447
SUFU GeneProduct ensembl:ENSG00000107882
CSNK1A1L GeneProduct ensembl:ENSG00000180138
HHIP GeneProduct ensembl:ENSG00000164161
ARRB1 GeneProduct ensembl:ENSG00000137486
PRKACA GeneProduct ensembl:ENSG00000072062
GLI1 GeneProduct ensembl:ENSG00000111087
KIF3A GeneProduct ensembl:ENSG00000131437
CSNK1A1 GeneProduct ensembl:ENSG00000113712
PTCH1 GeneProduct ensembl:ENSG00000185920
SMO GeneProduct ensembl:ENSG00000128602
EVC GeneProduct hgnc.symbol:EVC
CSNK1G3 GeneProduct ensembl:ENSG00000151292
CSNK1D GeneProduct ensembl:ENSG00000141551
CSNK1G1 GeneProduct ensembl:ENSG00000169118
CSNK1E GeneProduct ensembl:ENSG00000213923
DHH GeneProduct ensembl:ENSG00000139549
SHH GeneProduct ensembl:ENSG00000164690
IHH GeneProduct ensembl:ENSG00000163501
PTCH2 GeneProduct ensembl:ENSG00000117425
HHIP GeneProduct ensembl:ENSG00000164161
PTCH1 GeneProduct ensembl:ENSG00000185920
PTCH2 GeneProduct ensembl:ENSG00000117425
SMURF1 GeneProduct ensembl:ENSG00000198742
SMURF2 GeneProduct ensembl:ENSG00000108854
LRP2 GeneProduct ensembl:ENSG00000081479
CDON GeneProduct ensembl:ENSG00000064309
BOC GeneProduct ensembl:ENSG00000144857
SMO GeneProduct ensembl:ENSG00000128602
EVC2 GeneProduct ensembl:ENSG00000173040
PRKACB GeneProduct ensembl:ENSG00000142875
PRKACG GeneProduct ensembl:ENSG00000165059
GRK3 GeneProduct ensembl:ENSG00000100077
ARRB2 GeneProduct ensembl:ENSG00000141480
GLI2 GeneProduct ensembl:ENSG00000074047
GLI3 GeneProduct ensembl:ENSG00000106571
GLI1 GeneProduct ensembl:ENSG00000111087
GLI2 GeneProduct ensembl:ENSG00000074047
GLI3 GeneProduct ensembl:ENSG00000106571
KIF7 GeneProduct ensembl:ENSG00000166813
GPR161 GeneProduct ensembl:ENSG00000143147
GPR161 GeneProduct ensembl:ENSG00000143147
SUFU GeneProduct ensembl:ENSG00000107882
SPOP GeneProduct ensembl:ENSG00000121067
SPOPL GeneProduct ensembl:ENSG00000144228
CUL3 GeneProduct ensembl:ENSG00000036257
SPOP GeneProduct ensembl:ENSG00000121067
SPOPL GeneProduct ensembl:ENSG00000144228
CUL3 GeneProduct ensembl:ENSG00000036257
GLI1 GeneProduct ensembl:ENSG00000111087
GLI2 GeneProduct ensembl:ENSG00000074047
GLI3 GeneProduct ensembl:ENSG00000106571
PTCH1 GeneProduct ensembl:ENSG00000185920
PTCH2 GeneProduct ensembl:ENSG00000117425
CCND1 GeneProduct ensembl:ENSG00000110092
CCND2 GeneProduct ensembl:ENSG00000118971
BCL2 GeneProduct ensembl:ENSG00000171791
SMO GeneProduct ensembl:ENSG00000128602

References

  1. Raducu M, Fung E, Serres S, Infante P, Barberis A, Fischer R, et al. SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development. EMBO J. 2016 Jul 1;35(13):1400–16. PubMed Europe PMC Scholia