Ethanol metabolism production of ROS by CYP2E1 (WP4269)

Metabolism of Ethanol resulting in production of ROS by CYP2E1. Also includes a list of other CYP2E1 substrates and their metabolite outcomes. This pathway is also available for rat and mouse.
last edited

Authors

AdoBioInfo, Egonw, Marvin M2, Fehrhart, MaintBot, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Participants

Label Type Compact Identifier
Staurosporine Metabolite chebi:57491
MAPK8 GeneProduct ensembl:ENSG00000107643
CYP2E1 GeneProduct ensembl:ENSG00000130649
Acetaldehyde Metabolite chebi:15343
Ethanol Metabolite chebi:16236
CYP2E1 GeneProduct ensembl:ENSG00000130649
SP1 GeneProduct ensembl:ENSG00000185591
MAP2K2 GeneProduct ensembl:ENSG00000126934
Vitamin C Metabolite chebi:38290
Diallyl sulfide Metabolite chebi:4489
MAFF GeneProduct ensembl:ENSG00000185022
MAFG GeneProduct ensembl:ENSG00000197063
Protein kinase C Protein uniprot:A0A087X0I9
MAP2K1 GeneProduct ensembl:ENSG00000169032
U0126 Metabolite chebi:90693
MAFK GeneProduct ensembl:ENSG00000198517
NFE2L2 GeneProduct ensembl:ENSG00000116044
SP1 GeneProduct ensembl:ENSG00000185591
CYP2E1 GeneProduct ensembl:ENSG00000130649
NFE2L2 GeneProduct ensembl:ENSG00000116044
Fluoride Metabolite chebi:17051
Enflurane Metabolite hmdb:HMDB0014373
Halothane Metabolite chebi:5615
Sevoflurane Metabolite chebi:9130
6-Hydroxychlorzoxazone Metabolite hmdb:HMDB0060998
Isoflurane Metabolite chebi:6015
NAPQI Metabolite chebi:29132
Methoxyflurane Metabolite chebi:6843
Acetaminophen Metabolite chebi:46195
Chlorzoxazone Metabolite chebi:3655
Trifluoroacetic acid Metabolite chebi:45892
Fluoride Metabolite chebi:17051
Fluoride Metabolite chebi:17051

References

  1. Jin M, Ande A, Kumar A, Kumar S. Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway. Cell Death Dis. 2013 Mar 21;4(3):e554. PubMed Europe PMC Scholia