Wnt signaling (WP428)

Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. Source: [http://www.genome.jp/kegg/pathway/hsa/hsa04310.html KEGG]. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP428 CPTAC Assay Portal]
last edited

Authors

M.Lieberman, MaintBot, AlexanderPico, MartijnVanIersel, Khanspers, Thomas, Ewexler, Zari, Mkutmon, Fehrhart, Egonw, DeSl, and Eweitz

Cited In

Organism

Homo sapiens

Communities

CPTAC

Annotations

Pathway Ontology: Wnt signaling, canonical pathway Wnt signaling pathway

Participants

Label Type Compact Identifier
DVL3 GeneProduct ncbigene:1857
RHOA GeneProduct ncbigene:387
RAC1 GeneProduct ncbigene:5879
PLAU GeneProduct ncbigene:5328
PRKCB GeneProduct ensembl:ENSG00000166501
CAMK2D GeneProduct ensembl:ENSG00000145349
FRAT1 GeneProduct ncbigene:10023
GSK3B GeneProduct ncbigene:2932
CSNK2B GeneProduct ensembl:ENSG00000204435
APC GeneProduct ncbigene:324
WNT3A GeneProduct ncbigene:89780
PPP3R1 GeneProduct ensembl:ENSG00000221823
PPP3R2 GeneProduct ensembl:ENSG00000188386
FZD3 GeneProduct ncbigene:7976
MAPK9 GeneProduct ncbigene:5601
LEF1 GeneProduct ensembl:ENSG00000138795
CSNK1E GeneProduct ncbigene:1454
CCND1 GeneProduct ncbigene:595
FZD8 GeneProduct ncbigene:8325
TCF7L1 GeneProduct ensembl:ENSG00000152284
WNT7A GeneProduct ncbigene:7476
TCF7L2 GeneProduct ensembl:ENSG00000148737
WNT11 GeneProduct ncbigene:7481
WNT1 GeneProduct ncbigene:7471
PRKCA GeneProduct ncbigene:5578
JUN GeneProduct ncbigene:3725
LRP5 GeneProduct ncbigene:4041
FZD10 GeneProduct ncbigene:11211
FZD7 GeneProduct ncbigene:8324
PPP3CC GeneProduct ensembl:ENSG00000120910
WNT5B GeneProduct ncbigene:81029
PPP3CA GeneProduct ensembl:ENSG00000138814
CTNNB1 GeneProduct ncbigene:1499
WNT2 GeneProduct ncbigene:7472
CSNK1A1 GeneProduct ensembl:ENSG00000113712
WNT2B GeneProduct ncbigene:7482
FZD4 GeneProduct ncbigene:6424
PRKCG GeneProduct ncbigene:5582
CAMK2B GeneProduct ensembl:ENSG00000058404
DVL2 GeneProduct ncbigene:1856
WNT6 GeneProduct ncbigene:7475
CCND3 GeneProduct ncbigene:896
WNT5A GeneProduct ncbigene:7474
ROR1 GeneProduct ncbigene:4919
FZD1 GeneProduct ncbigene:8321
LRP6 GeneProduct ncbigene:4040
KREM1 GeneProduct ncbigene:83999
WNT16 GeneProduct ncbigene:51384
FZD6 GeneProduct ncbigene:8323
CAMK2G GeneProduct ensembl:ENSG00000148660
RYK GeneProduct ncbigene:6259
WNT4 GeneProduct ncbigene:54361
CAMK2A GeneProduct ensembl:ENSG00000070808
WNT3 GeneProduct ncbigene:7473
CSNK2A1 GeneProduct ensembl:ENSG00000101266
AXIN1 GeneProduct ncbigene:8312
WNT10B GeneProduct ncbigene:7480
FZD5 GeneProduct ncbigene:7855
WNT7B GeneProduct ncbigene:7477
DVL1 GeneProduct ncbigene:1855
CHD8 GeneProduct ensembl:ENSG00000100888
PPP3CB GeneProduct ensembl:ENSG00000107758
WNT10A GeneProduct ncbigene:80326
CSNK1A1L GeneProduct ensembl:ENSG00000180138
CSNK2A3 GeneProduct ensembl:ENSG00000254598
FOSL1 GeneProduct ncbigene:8061
Focal Adhesion Pathway wikipathways:WP306
MAPK10 GeneProduct ensembl:ENSG00000050748
26S Proteasome Degradation Pathway wikipathways:WP183
MYC GeneProduct ncbigene:4609
CSNK2A2 GeneProduct ensembl:ENSG00000070770
CCND2 GeneProduct ncbigene:894
FZD9 GeneProduct ncbigene:8326
Ca2+ Metabolite hmdb:HMDB0000464
MAP3K7 GeneProduct ensembl:ENSG00000135341
TCF7 GeneProduct ensembl:ENSG00000081059
WNT16 GeneProduct ncbigene:51384
FZD2 GeneProduct ncbigene:2535
ROR2 GeneProduct ncbigene:4920
CTNNB1 GeneProduct ncbigene:1499
CTNNB1 GeneProduct ncbigene:1499
DKK1 GeneProduct ensembl:ENSG00000107984
DKK2 GeneProduct ensembl:ENSG00000155011
DKK4 GeneProduct ensembl:ENSG00000104371
SOST GeneProduct ensembl:ENSG00000167941
SERPINF1 GeneProduct ensembl:ENSG00000132386
FRAT2 GeneProduct ensembl:ENSG00000181274
CTNNB1 GeneProduct ncbigene:1499
SFRP1 GeneProduct ensembl:ENSG00000104332
SFRP2 GeneProduct ensembl:ENSG00000145423
SFRP4 GeneProduct ensembl:ENSG00000106483
SFRP5 GeneProduct ensembl:ENSG00000120057
NOTUM GeneProduct ensembl:ENSG00000185269
CER1 GeneProduct ensembl:ENSG00000147869
WIF1 GeneProduct ensembl:ENSG00000156076
PORCN GeneProduct ensembl:ENSG00000102312
WNT5B GeneProduct ncbigene:81029
WNT5A GeneProduct ncbigene:7474
FZD3 GeneProduct ncbigene:7976
FZD8 GeneProduct ncbigene:8325
FZD10 GeneProduct ncbigene:11211
FZD7 GeneProduct ncbigene:8324
FZD4 GeneProduct ncbigene:6424
FZD1 GeneProduct ncbigene:8321
FZD6 GeneProduct ncbigene:8323
FZD5 GeneProduct ncbigene:7855
FZD9 GeneProduct ncbigene:8326
FZD2 GeneProduct ncbigene:2535
PLCB1 GeneProduct ensembl:ENSG00000182621
PLCB2 GeneProduct ensembl:ENSG00000137841
PLCB3 GeneProduct ensembl:ENSG00000149782
PLCB4 GeneProduct ensembl:ENSG00000101333
NFATC1 GeneProduct ensembl:ENSG00000131196
NFATC2 GeneProduct ensembl:ENSG00000101096
NFATC3 GeneProduct ensembl:ENSG00000072736
NFATC4 GeneProduct ensembl:ENSG00000100968
NFATC1 GeneProduct ensembl:ENSG00000131196
NFATC2 GeneProduct ensembl:ENSG00000101096
NFATC3 GeneProduct ensembl:ENSG00000072736
NFATC4 GeneProduct ensembl:ENSG00000100968
FZD3 GeneProduct ncbigene:7976
FZD8 GeneProduct ncbigene:8325
FZD10 GeneProduct ncbigene:11211
FZD7 GeneProduct ncbigene:8324
FZD4 GeneProduct ncbigene:6424
FZD1 GeneProduct ncbigene:8321
FZD6 GeneProduct ncbigene:8323
FZD5 GeneProduct ncbigene:7855
FZD9 GeneProduct ncbigene:8326
FZD2 GeneProduct ncbigene:2535
GPC4 GeneProduct ensembl:ENSG00000076716
VANGL1 GeneProduct ensembl:ENSG00000173218
VANGL2 GeneProduct ensembl:ENSG00000162738
WNT11 GeneProduct ncbigene:7481
DVL3 GeneProduct ncbigene:1857
DVL2 GeneProduct ncbigene:1856
DVL1 GeneProduct ncbigene:1855
INVS GeneProduct ensembl:ENSG00000119509
PRICKLE1 GeneProduct ensembl:ENSG00000139174
PRICKLE2 GeneProduct ensembl:ENSG00000163637
NKD1 GeneProduct ensembl:ENSG00000140807
NKD2 GeneProduct ensembl:ENSG00000145506
DAAM1 GeneProduct ensembl:ENSG00000100592
DAAM2 GeneProduct ensembl:ENSG00000146122
ROCK2 GeneProduct ensembl:ENSG00000134318
MAPK8 GeneProduct ensembl:ENSG00000107643
MAPK SignalingPathway Pathway wikipathways:WP382
CXXC4 GeneProduct ensembl:ENSG00000168772
SENP2 GeneProduct ensembl:ENSG00000163904
NLK GeneProduct ensembl:ENSG00000087095
CTNNBIP1 GeneProduct ensembl:ENSG00000178585
SOX17 GeneProduct ensembl:ENSG00000164736
CTBP1 GeneProduct ensembl:ENSG00000159692
CTBP2 GeneProduct ensembl:ENSG00000175029

References

  1. Nusse R. Wnt signaling in disease and in development. Cell Res. 2005 Jan;15(1):28–32. PubMed Europe PMC Scholia