Metabolic reprogramming in colon cancer (WP4290)

Metabolic reprogramming in colon cancer. This pathway was created from a figure by Vasaikar S and Zhang B, Baylor College of Medicine, June 2018.
last edited

Authors

Khanspers, Egonw, AlexanderPico, and MaintBot

Cited In

Organism

Homo sapiens

Communities

CPTAC Diseases

Annotations

Pathway Ontology: altered carbohydrate metabolic pathway cancer pathway

Disease Ontology: colorectal cancer

Participants

Label Type Compact Identifier
NH3 Metabolite chebi:16134
Phosphoserine Metabolite chebi:45522
IC Metabolite chebi:16087
glucose Metabolite chebi:17234
GOT2 GeneProduct ensembl:ENSG00000125166
lipids Metabolite chebi:18059
IMP Metabolite chebi:17202
glutamate Metabolite chebi:14321
PPAT GeneProduct ensembl:ENSG00000128059
KG Metabolite chebi:16810
Cell cycleProliferation Pathway None
PSAT1 GeneProduct ensembl:ENSG00000135069
GLUD1 GeneProduct ensembl:ENSG00000148672
G6PD GeneProduct ensembl:ENSG00000160211
3PHP Metabolite chebi:18110
GLS GeneProduct ensembl:ENSG00000115419
SLC1A5 GeneProduct ensembl:ENSG00000105281
Asparagine Metabolite chebi:17196
PYCR1 GeneProduct ensembl:ENSG00000183010
G6P Metabolite chebi:4170
F6P Metabolite chebi:16084
HK3 GeneProduct ensembl:ENSG00000160883
GPI GeneProduct ensembl:ENSG00000105220
TIGAR GeneProduct ensembl:ENSG00000078237
PFKL GeneProduct ensembl:ENSG00000141959
G3P Metabolite hmdb:HMDB0001112
F1,6P Metabolite hmdb:HMDB0001058
GAPDH GeneProduct ensembl:ENSG00000111640
2PG Metabolite hmdb:HMDB0000362
1,3BPG Metabolite hmdb:HMDB0001270
3PG Metabolite hmdb:HMDB0000807
ALDOB GeneProduct ensembl:ENSG00000136872
PGK1 GeneProduct ensembl:ENSG00000102144
PGAM1 GeneProduct ensembl:ENSG00000171314
LDHA GeneProduct ensembl:ENSG00000134333
Lactate Metabolite hmdb:HMDB0000190
ENO1 GeneProduct ensembl:ENSG00000074800
Pyruvate Metabolite hmdb:HMDB0000243
PEP Metabolite hmdb:HMDB0000263
PKM GeneProduct ensembl:ENSG00000067225
SLC16A3 GeneProduct ensembl:ENSG00000141526
Lactate Metabolite hmdb:HMDB0000190
Acetyl-CoA Metabolite hmdb:HMDB0001206
PDHA1 GeneProduct ensembl:ENSG00000131828
Malate Metabolite hmdb:HMDB0000744
PDHB GeneProduct ensembl:ENSG00000168291
OAA Metabolite hmdb:HMDB0000223
ACO2 GeneProduct ensembl:ENSG00000100412
SUCLG2 GeneProduct ensembl:ENSG00000172340
DLST GeneProduct ensembl:ENSG00000119689
IDH2 GeneProduct ensembl:ENSG00000182054
citrate Metabolite hmdb:HMDB0000094
FH GeneProduct ensembl:ENSG00000091483
fumarate Metabolite hmdb:HMDB0000134
MDH2 GeneProduct ensembl:ENSG00000146701
S-CoA Metabolite hmdb:HMDB0001022
SDHB GeneProduct ensembl:ENSG00000117118
IDH3A GeneProduct ensembl:ENSG00000166411
Acetyl-CoA Metabolite hmdb:HMDB0001206
ACLY GeneProduct ensembl:ENSG00000131473
FASN GeneProduct ensembl:ENSG00000169710
PSPH GeneProduct ensembl:ENSG00000146733
SHMT2 GeneProduct ensembl:ENSG00000182199
PAICS GeneProduct ensembl:ENSG00000128050
serine Metabolite chebi:17822
glycine Metabolite chebi:15428
GART GeneProduct ensembl:ENSG00000159131
S7P Metabolite cas:2646-35-7
R5P Metabolite cas:3615-55-2
6PGA Metabolite hmdb:HMDB0001316
E4P Metabolite hmdb:HMDB0001321
Ri5P Metabolite cas:4151-19-3
TALDO1 GeneProduct ensembl:ENSG00000177156
RPIA GeneProduct ensembl:ENSG00000153574
TKT GeneProduct ensembl:ENSG00000163931
PGD GeneProduct ensembl:ENSG00000142657
glutamine Metabolite chebi:28300
Glutathione Metabolite chebi:16856
ROS Metabolite wikidata:Q424361
glutamine Metabolite chebi:28300
Proline Metabolite chebi:26271
PYCR2 GeneProduct ensembl:ENSG00000143811
SLC2A1 GeneProduct ensembl:ENSG00000117394
Purine synthesis Pathway None
Nucleotide synthesis Pathway None
Amino acid synthesis Pathway None

References

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  2. Greksák M, Lopes-Cardozo M, van den Bergh SG. Citrate synthesis in intact rat-liver mitochondria is irreversible. Eur J Biochem. 1982 Feb;122(2):423–7. PubMed Europe PMC Scholia
  3. Des Rosiers C, Di Donato L, Comte B, Laplante A, Marcoux C, David F, et al. Isotopomer analysis of citric acid cycle and gluconeogenesis in rat liver. Reversibility of isocitrate dehydrogenase and involvement of ATP-citrate lyase in gluconeogenesis. J Biol Chem. 1995 Apr 28;270(17):10027–36. PubMed Europe PMC Scholia
  4. Fernandez CA, Des Rosiers C. Modeling of liver citric acid cycle and gluconeogenesis based on 13C mass isotopomer distribution analysis of intermediates. J Biol Chem. 1995 Apr 28;270(17):10037–42. PubMed Europe PMC Scholia
  5. Johnson JD, Muhonen WW, Lambeth DO. Characterization of the ATP- and GTP-specific succinyl-CoA synthetases in pigeon. The enzymes incorporate the same alpha-subunit. J Biol Chem. 1998 Oct 16;273(42):27573–9. PubMed Europe PMC Scholia
  6. Sheu KF, Blass JP. The alpha-ketoglutarate dehydrogenase complex. Ann N Y Acad Sci. 1999;893:61–78. PubMed Europe PMC Scholia
  7. KREBS HA, HOLZACH O. The conversion of citrate into cis-aconitate and isocitrate in the presence of aconitase. Biochem J. 1952 Nov;52(3):527–8. PubMed Europe PMC Scholia