Metabolic reprogramming in colon cancer (WP4290)

Metabolic reprogramming in colon cancer. This pathway was created from a figure by Vasaikar S and Zhang B, Baylor College of Medicine, June 2018.
last edited


Khanspers, Egonw, AlexanderPico, and MaintBot

Cited In


Homo sapiens


CPTAC Diseases


Pathway Ontology: altered carbohydrate metabolic pathway cancer pathway

Disease Ontology: colorectal cancer


Label Type Compact Identifier
NH3 Metabolite chebi:16134
Phosphoserine Metabolite chebi:45522
IC Metabolite chebi:16087
glucose Metabolite chebi:17234
GOT2 GeneProduct ensembl:ENSG00000125166
lipids Metabolite chebi:18059
IMP Metabolite chebi:17202
glutamate Metabolite chebi:14321
PPAT GeneProduct ensembl:ENSG00000128059
KG Metabolite chebi:16810
Cell cycleProliferation Pathway None
PSAT1 GeneProduct ensembl:ENSG00000135069
GLUD1 GeneProduct ensembl:ENSG00000148672
G6PD GeneProduct ensembl:ENSG00000160211
3PHP Metabolite chebi:18110
GLS GeneProduct ensembl:ENSG00000115419
SLC1A5 GeneProduct ensembl:ENSG00000105281
Asparagine Metabolite chebi:17196
PYCR1 GeneProduct ensembl:ENSG00000183010
G6P Metabolite chebi:4170
F6P Metabolite chebi:16084
HK3 GeneProduct ensembl:ENSG00000160883
GPI GeneProduct ensembl:ENSG00000105220
TIGAR GeneProduct ensembl:ENSG00000078237
PFKL GeneProduct ensembl:ENSG00000141959
G3P Metabolite hmdb:HMDB0001112
F1,6P Metabolite hmdb:HMDB0001058
GAPDH GeneProduct ensembl:ENSG00000111640
2PG Metabolite hmdb:HMDB0000362
1,3BPG Metabolite hmdb:HMDB0001270
3PG Metabolite hmdb:HMDB0000807
ALDOB GeneProduct ensembl:ENSG00000136872
PGK1 GeneProduct ensembl:ENSG00000102144
PGAM1 GeneProduct ensembl:ENSG00000171314
LDHA GeneProduct ensembl:ENSG00000134333
Lactate Metabolite hmdb:HMDB0000190
ENO1 GeneProduct ensembl:ENSG00000074800
Pyruvate Metabolite hmdb:HMDB0000243
PEP Metabolite hmdb:HMDB0000263
PKM GeneProduct ensembl:ENSG00000067225
SLC16A3 GeneProduct ensembl:ENSG00000141526
Lactate Metabolite hmdb:HMDB0000190
Acetyl-CoA Metabolite hmdb:HMDB0001206
PDHA1 GeneProduct ensembl:ENSG00000131828
Malate Metabolite hmdb:HMDB0000744
PDHB GeneProduct ensembl:ENSG00000168291
OAA Metabolite hmdb:HMDB0000223
ACO2 GeneProduct ensembl:ENSG00000100412
SUCLG2 GeneProduct ensembl:ENSG00000172340
DLST GeneProduct ensembl:ENSG00000119689
IDH2 GeneProduct ensembl:ENSG00000182054
citrate Metabolite hmdb:HMDB0000094
FH GeneProduct ensembl:ENSG00000091483
fumarate Metabolite hmdb:HMDB0000134
MDH2 GeneProduct ensembl:ENSG00000146701
S-CoA Metabolite hmdb:HMDB0001022
SDHB GeneProduct ensembl:ENSG00000117118
IDH3A GeneProduct ensembl:ENSG00000166411
Acetyl-CoA Metabolite hmdb:HMDB0001206
ACLY GeneProduct ensembl:ENSG00000131473
FASN GeneProduct ensembl:ENSG00000169710
PSPH GeneProduct ensembl:ENSG00000146733
SHMT2 GeneProduct ensembl:ENSG00000182199
PAICS GeneProduct ensembl:ENSG00000128050
serine Metabolite chebi:17822
glycine Metabolite chebi:15428
GART GeneProduct ensembl:ENSG00000159131
S7P Metabolite cas:2646-35-7
R5P Metabolite cas:3615-55-2
6PGA Metabolite hmdb:HMDB0001316
E4P Metabolite hmdb:HMDB0001321
Ri5P Metabolite cas:4151-19-3
TALDO1 GeneProduct ensembl:ENSG00000177156
RPIA GeneProduct ensembl:ENSG00000153574
TKT GeneProduct ensembl:ENSG00000163931
PGD GeneProduct ensembl:ENSG00000142657
glutamine Metabolite chebi:28300
Glutathione Metabolite chebi:16856
ROS Metabolite wikidata:Q424361
glutamine Metabolite chebi:28300
Proline Metabolite chebi:26271
PYCR2 GeneProduct ensembl:ENSG00000143811
SLC2A1 GeneProduct ensembl:ENSG00000117394
Purine synthesis Pathway None
Nucleotide synthesis Pathway None
Amino acid synthesis Pathway None


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