Acute viral myocarditis (WP4298)

Viral myocarditis is a rare cardiac disease associated with the inflammation and injury of the myocardium. The downstream effects are a product of cooperation between viral processes and both the adaptive as innate host's immune response. Acute appearance of myocarditis is mostly idiopathic, i.e. of unknown origin. Primarily established on clinical observation and limited epidemiologic studies. Most studied cases are coxsackie, adeno and human immunodeficiency virus. Grey compartments describe extracellular matrix. Direct lines indicate downstream effects and dashed lines indicate speculative research.
last edited


Olivier.traets, Fehrhart, Egonw, Khanspers, MaintBot, Marvin M2, Eweitz, and Finterly

Cited In


Homo sapiens


Diseases Rare Diseases


Pathway Ontology: myocarditis pathway disease pathway cardiomyopathy pathway

Disease Ontology: viral infectious disease myocarditis

Cell Type Ontology: cardiac muscle cell


Label Type Compact Identifier
SOCS1 GeneProduct ensembl:ENSG00000185338
Nitric oxide synthase Protein uniprot:B3VK56
IFNG GeneProduct ensembl:ENSG00000111537
TGFB1 GeneProduct ensembl:ENSG00000105329
JAK1 GeneProduct ensembl:ENSG00000162434
STAT1 GeneProduct ensembl:ENSG00000115415
ECM-receptor interaction Pathway kegg.pathway:hsa04512
IL10 GeneProduct ensembl:ENSG00000136634
IL6 GeneProduct ensembl:ENSG00000136244
ganglioside GM1 Metabolite chebi:18216
Endothelin-1 Protein uniprot:P05305
STAT3 GeneProduct ensembl:ENSG00000168610
EIF4G2 GeneProduct ensembl:ENSG00000110321
CASP8 Protein ensembl:ENSG00000064012
ACTB GeneProduct ensembl:ENSG00000075624
prostaglandin E2 Metabolite chebi:606564
BAX GeneProduct ensembl:ENSG00000087088
ATF-2 Protein uniprot:P16951
SGCB GeneProduct ensembl:ENSG00000163069
ILK GeneProduct ensembl:ENSG00000166333
CD4 GeneProduct ensembl:ENSG00000010610
3C^PRO GeneProduct None
FYN GeneProduct ensembl:ENSG00000010810
MMP9 GeneProduct ensembl:ENSG00000100985
DAF Protein uniprot:A0A1U8D6D6
RAC2 GeneProduct ensembl:ENSG00000128340
ABL1 GeneProduct ensembl:ENSG00000097007
BCL2L1 GeneProduct ensembl:ENSG00000171552
RAF-1 Metabolite hmdb:HMDB0003213
CASP2 GeneProduct ensembl:ENSG00000106144
MK2 Protein None
pro-IL-1beta GeneProduct None
CASP6 GeneProduct ensembl:ENSG00000138794
Tyrosine kinase Protein None
CASP7 GeneProduct ensembl:ENSG00000165806
NOD2 Protein uniprot:E9PLF7
CCR5 GeneProduct ensembl:ENSG00000160791
TLR3 GeneProduct ensembl:ENSG00000164342
CYCS GeneProduct ensembl:ENSG00000172115
MEK 1/2 Protein None
PTCRA GeneProduct ensembl:ENSG00000171611
p53 Protein uniprot:A0A0R4J1K8
TNF-a Protein ensembl:ENSG00000232810
BH3 Bid Protein uniprot:A8ASI8
peptidoglycan muramyl dipeptide GeneProduct None
Catenin beta-1 Protein uniprot:E9PW26
IgG GeneProduct None
Herbimycin A Metabolite chebi:5674
glycophosphatidylinositol Metabolite chebi:63419
Pro-IL-18 GeneProduct None
IL1 GeneProduct pfam:PF00340
CHRAC1 GeneProduct ensembl:ENSG00000104472
MKK 3/6 Protein None
Ca2+ Metabolite hmdb:HMDB0000464
AIF1 GeneProduct ensembl:ENSG00000204472
CCND1 GeneProduct ensembl:ENSG00000110092
JNK1 Protein uniprot:A0A087WVY6
TICAM1 GeneProduct hgnc.symbol:TICAM1
SOS1 GeneProduct ensembl:ENSG00000115904
MAPK1 GeneProduct ensembl:ENSG00000100030
RASA1 GeneProduct ensembl:ENSG00000145715
SRC Protein ensembl:ENSG00000197122
SGCA GeneProduct ensembl:ENSG00000108823
TNFRSM5 Protein uniprot:P27512
DFFB-45 GeneProduct ensembl:ENSG00000169598
GSK3B GeneProduct ensembl:ENSG00000082701
AKT1 GeneProduct ensembl:ENSG00000142208
MHCII Protein None
MHC-1 Protein uniprot:A0A024RCL3
CD55 GeneProduct ensembl:ENSG00000196352
CARCXADR Protein ensembl:ENSG00000154639
Viral entryCVB3 GeneProduct None
T cell receptor alpha chain V region GeneProduct None
SGCD GeneProduct ensembl:ENSG00000170624
HLA-DMA GeneProduct ensembl:ENSG00000204257
ENDOG GeneProduct ensembl:ENSG00000167136
TLR4 GeneProduct ensembl:ENSG00000136869
IL1 Protein uniprot:G3V169
PYCARD GeneProduct ensembl:ENSG00000103490
DFFA/ICAD GeneProduct ensembl:ENSG00000160049
hsp27 Protein None
c-Jun Protein uniprot:Q9WVI9
Perforin-1 Protein uniprot:P10820
PIK3 GeneProduct ensembl:ENSG00000145675
Cd28 GeneProduct ncbigene:12487
ITGAL GeneProduct ensembl:ENSG00000005844
LAMA2 GeneProduct ensembl:ENSG00000196569
CREB1 GeneProduct ensembl:ENSG00000118260
CXCR4 GeneProduct ensembl:ENSG00000121966
ITGB2 GeneProduct ensembl:ENSG00000160255
NFKB2 GeneProduct ensembl:ENSG00000077150
CASP3 GeneProduct ensembl:ENSG00000164305
Matrix metalloproteinases Protein None
IL12A GeneProduct ensembl:ENSG00000168811
KRT8 GeneProduct ensembl:ENSG00000170421
MYH6 GeneProduct ensembl:ENSG00000197616
IL2 Protein uniprot:P60568
RAC3 GeneProduct ensembl:ENSG00000169750
DMD GeneProduct ensembl:ENSG00000198947
135 S A-particle Rna None
BCL2 GeneProduct ensembl:ENSG00000171791
DAP5 GeneProduct ensembl:ENSG00000110321
2A^PRO GeneProduct None
DAG1-B GeneProduct ncbigene:1605
TLR5 GeneProduct ensembl:ENSG00000187554
T-cell receptor beta chain V region GeneProduct None
Striated muscle contraction Pathway wikipathways:WP383
NLRP3 GeneProduct None
CASP9 GeneProduct ensembl:ENSG00000132906
MKK 4/7 Protein None
CCR3 GeneProduct ensembl:ENSG00000183625
Dystrophin Protein uniprot:A2A9Z1
DAG1-a GeneProduct ensembl:ENSG00000173402
Macrophage GeneProduct None
EIF4G1 GeneProduct ensembl:ENSG00000114867
SGCG GeneProduct ensembl:ENSG00000102683
CD40LG GeneProduct ensembl:ENSG00000102245
BNIP2 GeneProduct ensembl:ENSG00000140299
PAR Metabolite None
Myocarditis Pathway kegg.pathway:map05416
ABL2 GeneProduct ensembl:ENSG00000143322
reactive oxygen species generators Metabolite chebi:70982
NF-kB GeneProduct None
MAPK3 GeneProduct ensembl:ENSG00000102882
CD80 GeneProduct ensembl:ENSG00000121594
CAV1 GeneProduct ensembl:ENSG00000105974
IgG GeneProduct None
cd86 Protein uniprot:D3Z363
glycophosphatidylinositol Metabolite chebi:63419
BH3 Bid Protein uniprot:A8ASI8
Ca2+ Metabolite hmdb:HMDB0000464
PTCRA GeneProduct ensembl:ENSG00000171611
CAAP1 GeneProduct ensembl:ENSG00000120159
PARP1 GeneProduct ensembl:ENSG00000143799
PABPC1 GeneProduct ensembl:ENSG00000070756
Proteasome Pathway kegg.pathway:hsa03050
MAPK1 GeneProduct ensembl:ENSG00000100030
IL12B GeneProduct ensembl:ENSG00000113302


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