Mitochondrial complex I assembly model OXPHOS system (WP4324)

This pathway shows how all 45 different subunits are assembled into complex 1 (relevant for the electron transport chain, also known as OXPHOS system), which chaperones(visualised with a small circle and a "C') and which post-translational modifications (a dimethylation on NDUFS2 and hydroxylation on NDUFS7, both in the Q-module) are needed for this assembly. Most of the steps involved in this intricate process have been described in separate literature references, which have been combined in a review by Alba Signes and Erika Fernandez-Vizarra[https://doi.org/10.1042/EBC20170098]. If possible (based on the size of the protein in KD and available protein structures in Uniprot), the colour of the protein structure drawings have been matched to the annotated protein DataNodes. Abbreviations: IM, inner membrane; IMS, intermembrane space.
last edited

Authors

DeSl

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: electron transport chain pathway oxidative phosphorylation pathway

Participants

Label Type Compact Identifier
MT-ND5 Protein uniprot:P03915
NDUFB2 Protein uniprot:O95178
NDUFB3 Protein uniprot:O43676
NDUFB7 Protein uniprot:P17568
NDUFB8 Protein uniprot:O95169
NDUFB9 Protein uniprot:Q9Y6M9
NDUFAB1 Protein uniprot:O14561
DMAC1 Protein uniprot:Q96GE9
NDUFAF2 Protein uniprot:Q8N183
NDUFS3 Protein uniprot:O75489
NDUFB5 Protein uniprot:O43674
TIMMDC1 Protein uniprot:Q9NPL8
Electron Transport Chain PW Pathway wikipathways:WP111
MT-ND4 Protein uniprot:P03905
NDUFAF3 Protein uniprot:Q9BU61
DMAC1 Protein uniprot:Q96GE9
FOXRED1 Protein uniprot:Q96CU9
[4Fe-4A]clusters Metabolite chebi:64607
NDUFV1 Protein uniprot:P49821
NDUFA5 Protein uniprot:Q16718
MT-ND1 Protein uniprot:P03886
NDUFAF2 Protein uniprot:Q8N183
NDUFA1 Protein uniprot:O15239
COA1 Protein uniprot:Q9GZY4
MT-ND3 Protein uniprot:Q9GZY4
TMEM126B Protein uniprot:Q8IUX1
NDUFS1 Protein uniprot:P28331
TMEM186 Protein uniprot:Q96B77
NDUFA6 Protein uniprot:P56556
NDUFA3 Protein uniprot:O95167
MT-ND5 Protein uniprot:P03915
NDUFV2 Protein uniprot:P19404
NDUFA2 Protein uniprot:O43678
NDUFV1 Protein uniprot:P49821
NDUFV2 Protein uniprot:P19404
NDUFS1 Protein uniprot:P28331
NDUFA2 Protein uniprot:O43678
NDUFA7 Protein uniprot:O95182
NDUFA12 Protein uniprot:Q9UI09
NDUFS4 Protein uniprot:O43181
NDUFS6 Protein uniprot:O75380
NDUFV3 Protein uniprot:P56181
NDUFB10 Protein uniprot:O96000
NDUFB11 Protein uniprot:Q9NX14
NDUFB6 Protein uniprot:O95139
NDUFB5 Protein uniprot:O43674
NDUFB10 Protein uniprot:O96000
NDUFB11 Protein uniprot:Q9NX14
NDUFB6 Protein uniprot:O95139
NDUFB1 Protein uniprot:O75438
NDUFB4 Protein uniprot:O95168
NDUFB5 Protein uniprot:O43674
NDUFB10 Protein uniprot:O96000
NDUFB11 Protein uniprot:Q9NX14
NDUFB6 Protein uniprot:O95139
MT-ND4 Protein uniprot:P03905
NDUFB1 Protein uniprot:O75438
NDUFB4 Protein uniprot:O95168
ATP5SL Protein uniprot:Q9NW81
TMEM70 Protein uniprot:Q9BUB7
MTND2 Protein uniprot:P03891
NDUFC1 Protein uniprot:O43677
NDUFC2 Protein uniprot:O95298
NDUFAF1 Protein uniprot:Q9Y375
ECSIT Protein uniprot:Q9BQ95
ACAD9 Protein uniprot:Q9H845
MT-ND3 Protein uniprot:Q9GZY4
MT-ND6 Protein uniprot:P03923
MT-ND4L Protein uniprot:P03901
MT-ND6 Protein uniprot:P03923
MT-ND4L Protein uniprot:P03901
MTND2 Protein uniprot:P03891
NDUFC1 Protein uniprot:O43677
NDUFC2 Protein uniprot:O95298
NDUFAF1 Protein uniprot:Q9Y375
ECSIT Protein uniprot:Q9BQ95
ACAD9 Protein uniprot:Q9H845
MT-ND3 Protein uniprot:Q9GZY4
MTND2 Protein uniprot:P03891
NDUFC1 Protein uniprot:O43677
NDUFC2 Protein uniprot:O95298
NDUFAF1 Protein uniprot:Q9Y375
ECSIT Protein uniprot:Q9BQ95
ACAD9 Protein uniprot:Q9H845
COA1 Protein uniprot:Q9GZY4
COA1 Protein uniprot:Q9GZY4
TMEM186 Protein uniprot:Q96B77
COA1 Protein uniprot:Q9GZY4
NDUFA10 Protein uniprot:O95299
NDUFS5 Protein uniprot:O43920
MT-ND6 Protein uniprot:P03923
MT-ND4L Protein uniprot:P03901
MT-ND3 Protein uniprot:Q9GZY4
MTND2 Protein uniprot:P03891
NDUFC1 Protein uniprot:O43677
NDUFC2 Protein uniprot:O95298
NDUFAF1 Protein uniprot:Q9Y375
ECSIT Protein uniprot:Q9BQ95
ACAD9 Protein uniprot:Q9H845
NDUFA1 Protein uniprot:O15239
NDUFA10 Protein uniprot:O95299
NDUFS5 Protein uniprot:O43920
TMEM186 Protein uniprot:Q96B77
COA1 Protein uniprot:Q9GZY4
TMEM126B Protein uniprot:Q8IUX1
NDUFAF1 Protein uniprot:Q9Y375
ECSIT Protein uniprot:Q9BQ95
ACAD9 Protein uniprot:Q9H845
NDUFAF6 Protein uniprot:Q330K2
NUBPL Protein uniprot:Q8TB37
NDUFS2 Protein uniprot:O75306
NDUFAF7 Protein uniprot:Q7L592
[4Fe-4A]clusters Metabolite chebi:64607
NUBPL Protein uniprot:Q8TB37
[4Fe-4A]clusters Metabolite chebi:64607
NDUFS2 Protein uniprot:O75306
NDUFS8 Protein uniprot:O
NDUFAF5 Protein uniprot:Q
NDUFS7 Protein uniprot:O
NDUFS7 Protein uniprot:O
NDUFAF4 Protein uniprot:Q9P032
[4Fe-4A]clusters Metabolite chebi:64607
NDUFS3 Protein uniprot:O75489
NDUFA5 Protein uniprot:Q16718
NDUFS2 Protein uniprot:O75306
NDUFS8 Protein uniprot:O
NDUFS7 Protein uniprot:O
NDUFAF6 Protein uniprot:Q330K2
NDUFAF3 Protein uniprot:Q9BU61
NDUFAF4 Protein uniprot:Q9P032
NDUFA8 Protein uniprot:P51970
NDUFA13 Protein uniprot:Q9P0J0
[4Fe-4A]clusters Metabolite chebi:64607
NDUFS3 Protein uniprot:O75489
NDUFA5 Protein uniprot:Q16718
NDUFS2 Protein uniprot:O75306
NDUFS8 Protein uniprot:O
NDUFS7 Protein uniprot:O
NDUFAF6 Protein uniprot:Q330K2
NDUFAF3 Protein uniprot:Q9BU61
NDUFAF4 Protein uniprot:Q9P032
MT-ND1 Protein uniprot:P03886
TIMMDC1 Protein uniprot:Q9NPL8
[4Fe-4A]clusters Metabolite chebi:64607
NDUFS3 Protein uniprot:O75489
NDUFA5 Protein uniprot:Q16718
NDUFS2 Protein uniprot:O75306
NDUFS8 Protein uniprot:O
NDUFS7 Protein uniprot:O
NDUFAF6 Protein uniprot:Q330K2
NDUFAF3 Protein uniprot:Q9BU61
NDUFAF4 Protein uniprot:Q9P032
MT-ND1 Protein uniprot:P03886
TIMMDC1 Protein uniprot:Q9NPL8
NDUFA3 Protein uniprot:O95167
NDUFA8 Protein uniprot:P51970
NDUFA13 Protein uniprot:Q9P0J0
NDUFB2 Protein uniprot:O95178
NDUFB3 Protein uniprot:O43676
NDUFB7 Protein uniprot:P17568
NDUFB8 Protein uniprot:O95169
NDUFB9 Protein uniprot:Q9Y6M9
NDUFAB1 Protein uniprot:O14561
MT-ND5 Protein uniprot:P03915
NDUFB2 Protein uniprot:O95178
NDUFB3 Protein uniprot:O43676
NDUFB7 Protein uniprot:P17568
NDUFB8 Protein uniprot:O95169
NDUFB9 Protein uniprot:Q9Y6M9
NDUFAB1 Protein uniprot:O14561
DMAC1 Protein uniprot:Q96GE9
MT-ND6 Protein uniprot:P03923
MT-ND4L Protein uniprot:P03901
MT-ND3 Protein uniprot:Q9GZY4
MTND2 Protein uniprot:P03891
NDUFC1 Protein uniprot:O43677
NDUFC2 Protein uniprot:O95298
NDUFAF1 Protein uniprot:Q9Y375
ECSIT Protein uniprot:Q9BQ95
ACAD9 Protein uniprot:Q9H845
NDUFA1 Protein uniprot:O15239
NDUFA10 Protein uniprot:O95299
NDUFS5 Protein uniprot:O43920
COA1 Protein uniprot:Q9GZY4
COA1 Protein uniprot:Q9GZY4
TMEM186 Protein uniprot:Q96B77
COA1 Protein uniprot:Q9GZY4
TMEM186 Protein uniprot:Q96B77
COA1 Protein uniprot:Q9GZY4
FOXRED1 Protein uniprot:Q96CU9
ATP5SL Protein uniprot:Q9NW81
TMEM70 Protein uniprot:Q9BUB7
TMEM186 Protein uniprot:Q96B77
COA1 Protein uniprot:Q9GZY4
MT-ND6 Protein uniprot:P03923
MT-ND4L Protein uniprot:P03901
MT-ND3 Protein uniprot:Q9GZY4
MTND2 Protein uniprot:P03891
NDUFC1 Protein uniprot:O43677
NDUFC2 Protein uniprot:O95298
NDUFAF1 Protein uniprot:Q9Y375
ECSIT Protein uniprot:Q9BQ95
ACAD9 Protein uniprot:Q9H845
NDUFA1 Protein uniprot:O15239
NDUFA10 Protein uniprot:O95299
NDUFS5 Protein uniprot:O43920
FOXRED1 Protein uniprot:Q96CU9
ATP5SL Protein uniprot:Q9NW81
TMEM70 Protein uniprot:Q9BUB7
TMEM186 Protein uniprot:Q96B77
COA1 Protein uniprot:Q9GZY4
[4Fe-4A]clusters Metabolite chebi:64607
NDUFS3 Protein uniprot:O75489
NDUFA5 Protein uniprot:Q16718
NDUFS2 Protein uniprot:O75306
NDUFS8 Protein uniprot:O
NDUFS7 Protein uniprot:O
NDUFAF6 Protein uniprot:Q330K2
NDUFAF3 Protein uniprot:Q9BU61
NDUFAF4 Protein uniprot:Q9P032
MT-ND1 Protein uniprot:P03886
TIMMDC1 Protein uniprot:Q9NPL8
NDUFA3 Protein uniprot:O95167
NDUFA8 Protein uniprot:P51970
NDUFA13 Protein uniprot:Q9P0J0
MT-ND6 Protein uniprot:P03923
MT-ND4L Protein uniprot:P03901
MT-ND3 Protein uniprot:Q9GZY4
MTND2 Protein uniprot:P03891
NDUFC1 Protein uniprot:O43677
NDUFC2 Protein uniprot:O95298
NDUFAF1 Protein uniprot:Q9Y375
ECSIT Protein uniprot:Q9BQ95
ACAD9 Protein uniprot:Q9H845
NDUFA1 Protein uniprot:O15239
NDUFA10 Protein uniprot:O95299
NDUFS5 Protein uniprot:O43920
FOXRED1 Protein uniprot:Q96CU9
ATP5SL Protein uniprot:Q9NW81
TMEM70 Protein uniprot:Q9BUB7
TMEM186 Protein uniprot:Q96B77
COA1 Protein uniprot:Q9GZY4
[4Fe-4A]clusters Metabolite chebi:64607
NDUFS3 Protein uniprot:O75489
NDUFA5 Protein uniprot:Q16718
NDUFS2 Protein uniprot:O75306
NDUFS8 Protein uniprot:O
NDUFS7 Protein uniprot:O
NDUFAF6 Protein uniprot:Q330K2
NDUFAF3 Protein uniprot:Q9BU61
NDUFAF4 Protein uniprot:Q9P032
MT-ND1 Protein uniprot:P03886
TIMMDC1 Protein uniprot:Q9NPL8
NDUFA3 Protein uniprot:O95167
NDUFA8 Protein uniprot:P51970
NDUFA13 Protein uniprot:Q9P0J0
MT-ND5 Protein uniprot:P03915
NDUFB2 Protein uniprot:O95178
NDUFB3 Protein uniprot:O43676
NDUFB7 Protein uniprot:P17568
NDUFB8 Protein uniprot:O95169
NDUFB9 Protein uniprot:Q9Y6M9
NDUFAB1 Protein uniprot:O14561
DMAC1 Protein uniprot:Q96GE9
NDUFAF2 Protein uniprot:Q8N183
MT-ND6 Protein uniprot:P03923
MT-ND4L Protein uniprot:P03901
MT-ND3 Protein uniprot:Q9GZY4
MTND2 Protein uniprot:P03891
NDUFC1 Protein uniprot:O43677
NDUFC2 Protein uniprot:O95298
NDUFAF1 Protein uniprot:Q9Y375
ECSIT Protein uniprot:Q9BQ95
ACAD9 Protein uniprot:Q9H845
NDUFA1 Protein uniprot:O15239
NDUFA10 Protein uniprot:O95299
NDUFS5 Protein uniprot:O43920
FOXRED1 Protein uniprot:Q96CU9
ATP5SL Protein uniprot:Q9NW81
TMEM70 Protein uniprot:Q9BUB7
TMEM186 Protein uniprot:Q96B77
COA1 Protein uniprot:Q9GZY4
[4Fe-4A]clusters Metabolite chebi:64607
NDUFS3 Protein uniprot:O75489
NDUFA5 Protein uniprot:Q16718
NDUFS2 Protein uniprot:O75306
NDUFS8 Protein uniprot:O
NDUFS7 Protein uniprot:O
NDUFAF6 Protein uniprot:Q330K2
NDUFAF3 Protein uniprot:Q9BU61
NDUFAF4 Protein uniprot:Q9P032
MT-ND1 Protein uniprot:P03886
TIMMDC1 Protein uniprot:Q9NPL8
NDUFA3 Protein uniprot:O95167
NDUFA8 Protein uniprot:P51970
NDUFA13 Protein uniprot:Q9P0J0
NDUFA6 Protein uniprot:P56556
NDUFA7 Protein uniprot:O95182
NDUFA12 Protein uniprot:Q9UI09
NDUFS4 Protein uniprot:O43181
NDUFS6 Protein uniprot:O75380
NDUFV3 Protein uniprot:P56181
NDUFV1 Protein uniprot:P49821
NDUFV2 Protein uniprot:P19404
NDUFS1 Protein uniprot:P28331
NDUFA2 Protein uniprot:O43678
TMEM126B Protein uniprot:Q8IUX1

References

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