Neovascularisation processes (WP4331)

Neovascularisation (aka new vessel formation) is a crucial process related to wound healing. It supplies oxygen and nutrients to, and carries waste from, damaged tissue. Angiogenesis is a subpart of Neovascularisation, being a vital process in growth, development and wound healing.
last edited


Carlosaxg, Fehrhart, and DeSl

Cited In


Homo sapiens



Pathway Ontology: cardiovascular system homeostasis pathway

Cell Type Ontology: endothelial cell


Label Type Compact Identifier
NFKB1 Protein uniprot:P19838
Notch1 GeneProduct uniprot:P46531
De novo arteriogenesis Pathway None
VEGFR3 GeneProduct ensembl:ENSG00000037280
VEGFR2 GeneProduct ensembl:ENSG00000128052
VEGF GeneProduct interpro:IPR000072
DLL2 GeneProduct None
FAK GeneProduct interpro:IPR036137
EPHB4 GeneProduct ensembl:ENSG00000196411
Proliferation Pathway None
Tube formation Pathway None
Migration Pathway None
Apoptosis Pathway None
Angiogenesis Pathway None
Integrins GeneProduct None
NO GeneProduct None
MMP9 GeneProduct ensembl:ENSG00000100985
mKitL GeneProduct ensembl:ENSG00000049130
sKitL GeneProduct ensembl:ENSG00000049130
cKit GeneProduct ensembl:ENSG00000157404
Arteriolar specification Pathway None
VEGF signalling Pathway None
Notch signalling Pathway None
DLL4 GeneProduct ensembl:ENSG00000128917
JAG1 GeneProduct ensembl:ENSG00000101384
Sprouting angiogenesis Pathway None
NOTCH3 GeneProduct ensembl:ENSG00000074181
CXCR4 GeneProduct ensembl:ENSG00000121966
SDF-1 GeneProduct ensembl:ENSG00000107562
Vasculogenesis Pathway None
EPHB4 GeneProduct ensembl:ENSG00000196411
Cell recruitment Pathway None
Vessel maturation Pathway None
PDGF-BB GeneProduct interpro:IPR000072
Remodeling arteriogenesis Pathway None
Ang-1 GeneProduct ensembl:ENSG00000154188
VEGFR GeneProduct uniprot:IPR009135
HIF-1alpha GeneProduct ensembl:ENSG00000100644
Shear stress Pathway None
Cell differentiation Pathway None
Matrix and collagendeposition Pathway None
TGF-beta1 GeneProduct ensembl:ENSG00000105329
TGF-beta2 GeneProduct ensembl:ENSG00000092969
TGF-beta3 GeneProduct ensembl:ENSG00000119699
SMAD1 GeneProduct ensembl:ENSG00000170365
SMAD2 GeneProduct ensembl:ENSG00000175387
TbetaR GeneProduct ensembl:ENSG00000106799
ALK1 GeneProduct ensembl:ENSG00000139567
ALK5 GeneProduct ensembl:ENSG00000106799
TGF-beta signalling Pathway None
EPHB2 GeneProduct ensembl:ENSG00000133216
ERK1 GeneProduct ensembl:ENSG00000102882
ERK2 GeneProduct ensembl:ENSG00000100030
PI3K GeneProduct interpro:IPR000403
Akt GeneProduct ncbigene:207
JNK2 GeneProduct uniprot:P45984
JNK1 GeneProduct ensembl:ENSG00000107643
SMAD5 GeneProduct ensembl:ENSG00000113658
Smad8 GeneProduct ensembl:ENSG00000120693
SMAD3 GeneProduct ensembl:ENSG00000166949
NFKB2 Protein uniprot:Q00653
RELA Protein uniprot:Q04206
RELB Protein uniprot:Q01201
REL Protein uniprot:Q04864
PDGF-beta GeneProduct ensembl:ENSG00000100311
Notch4 GeneProduct uniprot:Q99466
VEGF GeneProduct None
SDF- GeneProduct ensembl:ENSG00000107562


  1. Murakami M, Simons M. Fibroblast growth factor regulation of neovascularization. Curr Opin Hematol. 2008 May;15(3):215–20. PubMed Europe PMC Scholia