TCA cycle (WP434)

The [[wikipedia:citric_acid_cycle|citric acid cycle]], also known as the tricarboxylic acid cycle (TCA cycle) or the Krebs cycle, (or rarely, the Szent-Gyorgyi-Krebs cycle) is a series of enzyme-catalysed chemical reactions of central importance in all living cells that use oxygen as part of cellular respiration. In eukaryotes, the citric acid cycle occurs in the matrix of the mitochondrion. The components and reactions of the citric acid cycle were established by seminal work from both [[wikipedia:Albert_Szent-Gyorgyi|Albert Szent-Gyorgyi]] and [[wikipedia:Hans_Krebs|Hans Krebs]]. [From [[wikipedia:Main_Page|Wikipedia]]]
last edited


Kdahlquist, MaintBot, M.Braymer, AdrienDefay, MartijnVanIersel, Mkutmon, Ddigles, Egonw, and Eweitz

Cited In


Mus musculus



Pathway Ontology: citric acid cycle pathway


Label Type Compact Identifier
Pcx GeneProduct ncbigene:18563
Pdha1 GeneProduct ncbigene:18597
Pdhb GeneProduct ncbigene:68263
Oxaloacetate Metabolite hmdb:HMDB0000223
Pdk4 GeneProduct ncbigene:27273
Idh3b GeneProduct ncbigene:170718
Pdhx GeneProduct ncbigene:27402
Dlat GeneProduct ncbigene:235339
Fatty Acid Synthesis Pathway wikipathways:WP336
Dld GeneProduct ncbigene:13382
Sdha GeneProduct ncbigene:66945
Glycolysis Pathway wikipathways:WP157
Malate Metabolite hmdb:HMDB0000156
Isocitrate Metabolite hmdb:HMDB0000193
Mdh1 GeneProduct ncbigene:17449
Suclg2 GeneProduct ncbigene:20917
Aco2 GeneProduct ncbigene:11429
Ppm2c GeneProduct ncbigene:381511
Malate Metabolite hmdb:HMDB0000156
Suclg1 GeneProduct ncbigene:56451
Dlst GeneProduct ncbigene:78920
Succinate Metabolite hmdb:HMDB0000254
Pdk2 GeneProduct ncbigene:18604
Idh3g GeneProduct ncbigene:15929
Oxaloacetate Metabolite hmdb:HMDB0000223
Sdhc GeneProduct ncbigene:66052
Pdk1 GeneProduct ncbigene:228026
Pyruvate Metabolite hmdb:HMDB0000243
Acetyl-CoA Metabolite hmdb:HMDB0001206
alpha-Ketoglutarate Metabolite None
Gluconeogenesis Pathway wikipathways:WP157
Sdhd GeneProduct ncbigene:66925
Sdhb GeneProduct ncbigene:67680
Cs GeneProduct ncbigene:12974
Citrate Metabolite hmdb:HMDB0000094
Electron Transport Chain Pathway wikipathways:WP295
Sucla2 GeneProduct ncbigene:20916
Idh3a GeneProduct ncbigene:67834
Degradation of Fatty Acids Containing an Even Number of Carbons Pathway wikipathways:WP1269
Pdk3 GeneProduct ncbigene:236900
Dld GeneProduct ncbigene:13382
Idh2 GeneProduct ncbigene:269951
Ogdh GeneProduct ncbigene:18293
Pdha2 GeneProduct ncbigene:18598
4833426J09Rik GeneProduct ncbigene:382051
Fh1 GeneProduct ncbigene:14194
Fumarate Metabolite hmdb:HMDB0000134
Mdh2 GeneProduct ncbigene:17448
Succinyl-CoA Metabolite hmdb:HMDB0001022
Degradation of Fatty Acids Containing an Even Number of Carbons Pathway wikipathways:WP1269