Non-genomic actions of 1,25 dihydroxyvitamin D3 (WP4341)

The pathway summarizes the knowlegde on the non-genomic actions of the hormonally active form of vitamin D, 1,25 dihydroxyvitamin D3. It is based the pathway figure published by Hii and Ferrante (Nutrients, 2016).
last edited

Authors

Susan and MaintBot

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: vitamin D signaling pathway

Participants

Label Type Compact Identifier
CaMK2A GeneProduct ensembl:ENSG00000070808
CaMK2B GeneProduct ensembl:ENSG00000058404
CaMK2G GeneProduct ensembl:ENSG00000148660
PLCB1 GeneProduct ensembl:ENSG00000182621
PLCB2 GeneProduct ensembl:ENSG00000137841
PLCB3 GeneProduct ensembl:ENSG00000149782
PLCB4 GeneProduct ensembl:ENSG00000101333
PLCG1 GeneProduct ensembl:ENSG00000187091
PLCD1 GeneProduct ensembl:ENSG00000187091
PLCD3 GeneProduct ensembl:ENSG00000187091
PLCD4 GeneProduct ensembl:ENSG00000187091
PLCE1 GeneProduct ensembl:ENSG00000138193
TLR2 GeneProduct ensembl:ENSG00000137462
TLR8 GeneProduct ensembl:ENSG00000101916
PRKCE GeneProduct ensembl:ENSG00000171132
PRKCH GeneProduct ensembl:ENSG00000027075
PRKCQ GeneProduct ensembl:ENSG00000065675
PIK3CA GeneProduct insdc:ENSG00000121879
PIK3CB GeneProduct insdc:ENSG00000051382
PIK3CG GeneProduct insdc:ENSG00000105851
PIK3CD GeneProduct insdc:ENSG00000171608
PIK3R1 GeneProduct insdc:ENSG00000145675
PIK3R3 GeneProduct insdc:ENSG00000117461
PIK3R4 GeneProduct insdc:ENSG00000196455
PIK3R5 GeneProduct insdc:ENSG00000141506
PIK3C2A GeneProduct insdc:ENSG00000011405
PIK3C2B GeneProduct insdc:ENSG00000133056
PIK3C2G GeneProduct insdc:ENSG00000139144 
AKT1 GeneProduct insdc:ENSG00000142208
AKT2 GeneProduct insdc:ENSG00000105221
AKT3 GeneProduct insdc:ENSG00000117020
RXRB GeneProduct ensembl:ENSG00000204231
STAT1 GeneProduct ensembl:ENSG00000115415
STAT2 GeneProduct ensembl:ENSG00000170581
JAK1 GeneProduct ensembl:ENSG00000162434
IFI44L GeneProduct ensembl:ENSG00000137959
ISG15 GeneProduct ensembl:ENSG00000187608
OAS1 GeneProduct ensembl:ENSG00000089127 
OAS2 GeneProduct ensembl:ENSG00000111335
OAS3 GeneProduct ensembl:ENSG00000111331 
RSAD2 GeneProduct ensembl:ENSG00000134321
IKK2 GeneProduct ensembl:ENSG00000104365
PIK3R2 GeneProduct insdc:ENSG00000105647
Caveolin-1 Protein uniprot:Q03135
AA Metabolite hmdb:HMDB0001043
MED1 GeneProduct ensembl:ENSG00000125686
PLA2G1B GeneProduct insdc:ENSG00000170890
PLCG2 GeneProduct ensembl:ENSG00000197943
IFI27L GeneProduct ensembl:ENSG00000119632
PIK3C3 GeneProduct insdc:ENSG00000078142 
CYP27B1 GeneProduct ensembl:ENSG00000111012
25D Metabolite hmdb:HMDB0003550
SP3 GeneProduct ensembl:ENSG00000172845
PRKCG GeneProduct ensembl:ENSG00000126583
PRKCB GeneProduct ensembl:ENSG00000166501
PRKCA GeneProduct ensembl:ENSG00000154229
RXRG GeneProduct ensembl:ENSG00000143171
VSE GeneProduct None
CD40LG GeneProduct ensembl:ENSG00000102245
DAG GeneProduct MGI
PRKCD GeneProduct ensembl:ENSG00000163932
1,25D Metabolite hmdb:HMDB0001903
VDR GeneProduct ensembl:ENSG00000111424
PMA Metabolite chebi:37537
IFNR gamma GeneProduct None
RXRA GeneProduct ensembl:ENSG00000186350
CaMK2D GeneProduct ensembl:ENSG00000145349
ETS1 GeneProduct ensembl:ENSG00000134954
TLR4 GeneProduct ensembl:ENSG00000136869
25D Metabolite hmdb:HMDB0003550
VDRn GeneProduct ensembl:ENSG00000111424
CD40 GeneProduct ensembl:ENSG00000101017
INF gamma Protein uniprot:P01579
INF alpha Protein uniprot:P01563
IFNR alpha GeneProduct None
CYP27B1 GeneProduct ensembl:ENSG00000111012
VDR GeneProduct ensembl:ENSG00000111424
TYK2 GeneProduct ensembl:ENSG00000105397
STAT2 GeneProduct ensembl:ENSG00000170581
STAT1 GeneProduct ensembl:ENSG00000115415
AA Metabolite hmdb:HMDB0001043
1,25D Metabolite hmdb:HMDB0001903
VDRm/n GeneProduct ensembl:ENSG00000111424
VDR GeneProduct ensembl:ENSG00000111424
VDRn GeneProduct ensembl:ENSG00000111424
SP1 GeneProduct ensembl:ENSG00000185591
VDR GeneProduct ensembl:ENSG00000111424
cJUN GeneProduct ensembl:ENSG00000177606
KRAS GeneProduct ensembl:ENSG00000133703
HRAS GeneProduct ensembl:ENSG00000174775
NRAS GeneProduct ensembl:ENSG00000213281
MAPK3 GeneProduct ensembl:ENSG00000102882
MAPK1 GeneProduct ensembl:ENSG00000100030
MAPK7 GeneProduct ensembl:ENSG00000166484
MAPK8 GeneProduct ensembl:ENSG00000107643
MAPK9 GeneProduct ensembl:ENSG00000050748
PKC zeta GeneProduct ensembl:ENSG00000067606
VDRn GeneProduct ensembl:ENSG00000111424
NFKB1 GeneProduct ensembl:ENSG00000109320
RELB GeneProduct ensembl:ENSG00000104856
NFKB2 GeneProduct ensembl:ENSG00000077150
NFKB1 GeneProduct ensembl:ENSG00000109320
RELB GeneProduct ensembl:ENSG00000104856
NFKB2 GeneProduct ensembl:ENSG00000077150
MAPK8 GeneProduct ensembl:ENSG00000107643
MAPK9 GeneProduct ensembl:ENSG00000050748
TNFR1 GeneProduct ensembl:ENSG00000067182
TNF GeneProduct ensembl:ENSG00000232810
MAPK11 GeneProduct ensembl:ENSG00000185386
MAPK14 GeneProduct ensembl:ENSG00000112062
MAPK13 GeneProduct ensembl:ENSG00000156711
MAPK12 GeneProduct ensembl:ENSG00000188130
MAPK11 GeneProduct ensembl:ENSG00000185386
MAPK14 GeneProduct ensembl:ENSG00000112062
MAPK13 GeneProduct ensembl:ENSG00000156711
MAPK12 GeneProduct ensembl:ENSG00000188130
CYP24A1 GeneProduct ensembl:ENSG00000019186
CAMP GeneProduct ensembl:ENSG00000164047
DEFB4A GeneProduct ensembl:ENSG00000171711
NOD2 GeneProduct ensembl:ENSG00000167207
VDR GeneProduct ensembl:ENSG00000111424
CCL2 GeneProduct ensembl:ENSG00000108691
CXCL8 GeneProduct ensembl:ENSG00000169429
IL-6 GeneProduct ensembl:ENSG00000136244

References

  1. Hii CS, Ferrante A. The Non-Genomic Actions of Vitamin D. Nutrients. 2016 Mar 2;8(3):135. PubMed Europe PMC Scholia