Sphingolipid metabolism overview (WP4344)
This pathway is inspired by the Lipidmaps>Sphingolipids pathway [https://lipidmaps.org/pathway/pathways_maps]. Sphingolipids are a class of lipids, which act as signal transduction and cell recognition molecules. This pathway provides an overview of the different tail lengths (on the right), which are used to convert sphinganine to DH-ceramide. All products are annotated with a lipid-class identifier. The integrated pathway can be found [https://www.wikipathways.org/index.php/Pathway:WP4690 here].
Authors
Denise Slenter , Egon Willighagen , Maintenance bot , and Eric WeitzCited In
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Organism
Mus musculusCommunities
Lipids and LIPID MAPSAnnotations
Pathway Ontology: sphingolipid biosynthetic pathway sphingomyelin metabolic pathway sphingolipid metabolic pathway
Participants
| Label | Type | Compact Identifier |
|---|---|---|
| ATP | Metabolite | chebi:30616 |
| 3-keto-sphinganine | Metabolite | lipidmaps:LMSP01020002 |
| Palmitoyl-CoA | Metabolite | lipidmaps:LMFA07050360 |
| Serine | Metabolite | pubchem.compound:5951 |
| Hexadecanal | Metabolite | lipidmaps:LMFA06000088 |
| Ethanolamine-phosphate | Metabolite | pubchem.compound:1015 |
| H2O | Metabolite | chebi:15377 |
| Sphingosine | Metabolite | lipidmaps:LMSP01010001 |
| Sphinganine | Metabolite | lipidmaps:LMSP01020001 |
| Sphinganine-1-phosphate | Metabolite | lipidmaps:LMSP01050002 |
| DH-Ceramide | Metabolite | lipidmaps:LMSP02020000 |
| Ceramide | Metabolite | lipidmaps:LMSP02010000 |
| Cer-1-P | Metabolite | lipidmaps:LMSP02050000 |
| DH-Cer-1-P | Metabolite | lipidmaps:LMSP020500A0 |
| SM | Metabolite | lipidmaps:LMSP0301 |
| Glc-Cer | Metabolite | lipidmaps:LMSP0501AA00 |
| DH-SM | Metabolite | lipidmaps:LMSP030100A0 |
| Gal-Cer | Metabolite | lipidmaps:LMSP0501AC00 |
| Sphingosine-1-phosphate | Metabolite | lipidmaps:LMSP01050001 |
| 1-Hexadecenal | Metabolite | lipidmaps:LMFA06000088 |
| CoA(16:0) | Metabolite | lipidmaps:LMFA07050360 |
| CoA(18:0) | Metabolite | chebi:15541 |
| CoA(20:0) | Metabolite | chebi:15527 |
| CoA(22:0) | Metabolite | cas:24330-89-0 |
| CoA(24:0) | Metabolite | cas:24305-30-4 |
| CoA(24:1) | Metabolite | cas:88362-35-0 |
| CoA(16:0) | Metabolite | lipidmaps:LMFA07050360 |
| CoA(18:0) | Metabolite | chebi:15541 |
| CoA(20:0) | Metabolite | chebi:15527 |
| CoA(22:0) | Metabolite | cas:24330-89-0 |
| CoA(24:0) | Metabolite | cas:24305-30-4 |
| CoA(24:1) | Metabolite | cas:88362-35-0 |
| DH-Ceramide | Metabolite | lipidmaps:LMSP02020000 |
| DH-Ceramide | Metabolite | lipidmaps:LMSP02020000 |
| DH-Ceramide | Metabolite | lipidmaps:LMSP02020000 |
| DH-Ceramide | Metabolite | lipidmaps:LMSP02020000 |
| CoA(26:0) | Metabolite | cas:99313-57-2 |
| DH-Ceramide | Metabolite | lipidmaps:LMSP02020000 |
| CoA(26:0) | Metabolite | cas:99313-57-2 |
| ADP | Metabolite | chebi:456216 |
| Ppap2a | Protein | ncbigene:19012 |
| Cerk | Protein | ncbigene:223753 |
| Sgpp1 | Protein | uniprot:Q9JI99 |
| Asah1 | Protein | uniprot:Q9WV54 |
| Sgms1 | Protein | ncbigene:208449 |
| Sphk2 | Protein | uniprot:Q9JIA7 |
| Sgpl1 | Protein | ncbigene:20397 |
| Ugcg | Protein | ncbigene:22234 |
| Sptlc1 | Protein | ncbigene:268656 |
| Sphk1 | Protein | uniprot:Q8CI15 |
| Degs1 | Protein | ncbigene:13244 |
| Kdsr | Protein | uniprot:Q6GV12 |
| Sptlc2 | Protein | uniprot:P97363 |
| CerS4 | Protein | ncbigene:67260 |
| CerS5 | Protein | ncbigene:67260 |
| CerS6 | Protein | ncbigene:241447 |
| Smpd1 | Protein | ncbigene:20597 |
| Degs2 | Protein | ncbigene:70059 |
| Sgms2 | Protein | ncbigene:74442 |
| Ppap2b | Protein | ncbigene:67916 |
| Ppap2c | Protein | ncbiprotein:50784 |
| Ugt8a | Protein | ncbigene:22239 |
| CerS1 | Protein | uniprot:P27545 |
| CerS4 | Protein | ncbigene:67260 |
| Cers2 | Protein | ncbigene:76893 |
| Cers3 | Protein | uniprot:Q1A3B0 |
| Sgpp2 | Protein | uniprot:Q810K3 |
References
- Le Stunff H, Peterson C, Thornton R, Milstien S, Mandala SM, Spiegel S. Characterization of murine sphingosine-1-phosphate phosphohydrolase. J Biol Chem. 2002 Mar 15;277(11):8920–7. PubMed Europe PMC Scholia
- Merrill AH Jr. De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway. J Biol Chem. 2002 Jul 19;277(29):25843–6. PubMed Europe PMC Scholia
- Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. A mouse macrophage lipidome. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia