This pathway is inspired by the Lipidmaps>Glycerolipids and Glycerophospholipids Pathways expended pathway display [https://lipidmaps.org/pathway/pathways_maps]. Glycerolipids are composed of mono-, di-, and tri-substituted glycerols, which all function as energy storage. Glycerophospholipids are also based on glycerol phospholipids, and serve as the main component of biological membranes.

Authors

Eoin Fahy , Ryan Miller , Egon Willighagen , Denise Slenter , Eric Weitz , and Conroy lipids

Cited In

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Organism

Mus musculus

Communities

Lipids and LIPID MAPS

Annotations

Pathway Ontology: glycerophospholipid metabolic pathway glycerolipid metabolic pathway

Participants

Label	Type	Compact Identifier
CoA(16:0)	Metabolite	cas:1763-10-6
CoA	Metabolite	chebi:15346
PA	Metabolite	lipidmaps:LMGP10010000
Glycerol-3-P	Metabolite	pubchem.compound:439162
1-acyl-LPA	Metabolite	lipidmaps:LMGP10050000
Choline	Metabolite	pubchem.compound:305
CDP-Etn	Metabolite	pubchem.compound:123727
PE	Metabolite	lipidmaps:LMGP02010000
Acyl-CoA	Metabolite	lipidmaps:LMFA07050000
DAG	Metabolite	lipidmaps:LMGL02010000
CDP-DAG	Metabolite	lipidmaps:LMGP13010000
PGP	Metabolite	lipidmaps:LMGP05010000
PG	Metabolite	lipidmaps:LMGP04010000
CL	Metabolite	lipidmaps:LMGP12010000
PI	Metabolite	lipidmaps:LMGP06010000
PC	Metabolite	lipidmaps:LMGP01010000
Choline-P	Metabolite	pubchem.compound:135437
CDP-Choline	Metabolite	pubchem.compound:13804
PS	Metabolite	lipidmaps:LMGP03010000
1-acyl-LPC	Metabolite	lipidmaps:LMGP01050000
PE-Me	Metabolite	lipidmaps:LMGP0201AA00
PE-Me2	Metabolite	lipidmaps:LMGP0201AB00
Etn-P	Metabolite	pubchem.compound:1015
Etn	Metabolite	pubchem.compound:700
TAG	Metabolite	lipidmaps:LMGL03010000
2-acyl-PA	Metabolite	lipidmaps:LMGP1005AA00
1-acyl-PE	Metabolite	lipidmaps:LMGP02050000
CoA(18:0)	Metabolite	cas:362-66-3
CoA(20:0)	Metabolite	cas:15895-27-9
CoA(16:0)	Metabolite	cas:1763-10-6
CoA(16:0)	Metabolite	cas:1763-10-6
CoA(16:0)	Metabolite	cas:1763-10-6
CoA(16:0)	Metabolite	cas:1763-10-6
CoA(18:0)	Metabolite	cas:362-66-3
CoA(18:0)	Metabolite	cas:362-66-3
CoA(18:0)	Metabolite	cas:362-66-3
CoA(18:0)	Metabolite	cas:362-66-3
CoA(18:0)	Metabolite	cas:362-66-3
CoA(18:0)	Metabolite	cas:362-66-3
LPG	Metabolite	lipidmaps:LMGP04050000
LPI	Metabolite	lipidmaps:LMGP06050000
LPC	Metabolite	lipidmaps:LMGP01050000
LPS	Metabolite	lipidmaps:LMGP03050000
LPE	Metabolite	lipidmaps:LMGP02050000
Gpam	GeneProduct	ncbigene:14732
PPap2a	GeneProduct	ncbigene:19012
Crls1	GeneProduct	ncbigene:66586
Chpt1	GeneProduct	ncbigene:212862
Pcyt2	GeneProduct	ncbigene:68671
Cds1	GeneProduct	ncbigene:74596
Pisd	GeneProduct	ncbigene:320951
Dgat1	GeneProduct	ncbigene:13350
Ptdss2	GeneProduct	ncbigene:27388
Pnpla2	GeneProduct	ncbigene:66853
Pld1	GeneProduct	ncbigene:18805
Dgkz	GeneProduct	ncbigene:104418
Ptdss1	GeneProduct	ncbigene:19210
Pemt	GeneProduct	ncbigene:18618
Agpat4	GeneProduct	ncbigene:68262
Cdipt	GeneProduct	ncbigene:52858
Chkb	GeneProduct	ncbigene:12651
Pcyt1a	GeneProduct	ncbigene:13026
Etnk1	GeneProduct	ncbigene:75320
Agpat6	GeneProduct	ncbigene:102247
Dgat2	GeneProduct	ncbigene:67800
Pla2g1b	GeneProduct	ncbigene:18778
Pla2g1b	GeneProduct	ncbigene:18778
Pnpla3	Protein	ncbigene:116939

References

1. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. A mouse macrophage lipidome. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia
2. Yamashita A, Hayashi Y, Matsumoto N, Nemoto-Sasaki Y, Oka S, Tanikawa T, et al. Glycerophosphate/Acylglycerophosphate acyltransferases. Biology (Basel). 2014 Nov 19;3(4):801–30. PubMed Europe PMC Scholia