Eicosanoid metabolism via lipoxygenases (LOX) (WP4348)

This pathway is inspired by the Lipidmaps>Eicosanoids Pathway expended pathway display [https://lipidmaps.org/pathway/pathways_maps]. Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX)[https://www.wikipathways.org/index.php/Pathway:WP4347], lipooxygenases(LOX)[https://www.wikipathways.org/index.php/Pathway:WP4348], or cytochrome P450 monooxygenases (CYP)[https://www.wikipathways.org/index.php/Pathway:WP4349]. This pathway visualises the second route, via LOX. Green and orange boxes represent receptors, where the orange colour depicts peroxisome-proliferator activating receptors (PPARs) potentially activated by the eicosanoids.
last edited

Authors

Eoin Fahy , Ryan Miller , Denise Slenter , Egon Willighagen , and Eric Weitz

Cited In

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Organism

Mus musculus

Communities

Lipids and LIPID MAPS

Annotations

Pathway Ontology: eicosanoid metabolic pathway lipoxygenase mediated pathway of arachidonic acid metabolism

Participants

Label Type Compact Identifier
12(R)-HpETE Metabolite lipidmaps:LMFA03060070
LTA4 Metabolite lipidmaps:LMFA03020023
Arachidonic acid Metabolite lipidmaps:LMFA01030001
15-HpETE Metabolite lipidmaps:LMFA03060014
15-HETE Metabolite lipidmaps:LMFA03060087
8-HpETE Metabolite lipidmaps:LMFA03060073
8-HETE Metabolite lipidmaps:LMFA03060086
15-oxoETE Metabolite lipidmaps:LMFA03060051
LXA4 Metabolite lipidmaps:LMFA03040001
12-HpETE Metabolite lipidmaps:LMFA03060013
12-HETE Metabolite lipidmaps:LMFA03060088
12-oxoETE Metabolite lipidmaps:LMFA03060019
HXB3 Metabolite lipidmaps:LMFA03090003
HXA3 Metabolite lipidmaps:LMFA03090005
TXA3 Metabolite lipidmaps:LMFA03030005
TXB3 Metabolite lipidmaps:LMFA03030006
LXB4 Metabolite lipidmaps:LMFA03040002
LTB4 Metabolite lipidmaps:LMFA03020001
12-epi-LTB4 Metabolite lipidmaps:LMFA03020015
6-trans-12-epi-delta-LTB4 Metabolite lipidmaps:LMFA03020014
6-trans-delta-LTB4 Metabolite lipidmaps:LMFA03020013
LTC4 Metabolite lipidmaps:LMFA03020003
LTD4 Metabolite lipidmaps:LMFA03020006
LTE4 Metabolite lipidmaps:LMFA03020002
EXC4 Metabolite lipidmaps:LMFA03020031
EXD4 Metabolite lipidmaps:LMFA03020032
EXE4 Metabolite lipidmaps:LMFA03020033
20-hydroxy-LTB4 Metabolite lipidmaps:LMFA03020018
20-carboxy-LTB4 Metabolite lipidmaps:LMFA03020016
18-carboxy-dinor-LTB4 Metabolite lipidmaps:LMFA03020056
11-trans-LTC4 Metabolite lipidmaps:LMFA03020020
11-trans-LTD4 Metabolite lipidmaps:LMFA03020021
11-trans-LTE4 Metabolite lipidmaps:LMFA03020022
5-HpETE Metabolite lipidmaps:LMFA03060108
5-HETE Metabolite lipidmaps:LMFA03060084
5-oxoETE Metabolite lipidmaps:LMFA03060011
15-oxo-LXA4 Metabolite lipidmaps:LMFA03040009
13,14-dihydro-15-oxo-LXA4 Metabolite lipidmaps:LMFA03040008
12-oxo-LTB4 Metabolite lipidmaps:LMFA03020024
LXB4 Metabolite lipidmaps:LMFA03040002
15-HETE Metabolite lipidmaps:LMFA03060087
5,12-diHETE Metabolite lipidmaps:LMFA03060052
Cyp4a10 GeneProduct ncbigene:13117
Lta4h GeneProduct ncbigene:16993
Alox5 GeneProduct ncbigene:11689
Alox15 GeneProduct ncbigene:11687
Hpgd GeneProduct ncbigene:15446
Alox12 GeneProduct ncbigene:11684
Ltc4s GeneProduct ncbigene:17001
Cyp4a12a GeneProduct ncbigene:277753
Cyp4a12b GeneProduct ncbigene:13118
Cyp4f14 GeneProduct ncbigene:64385
Cyp4f18 GeneProduct ncbigene:72054
Acox1 GeneProduct ncbigene:11430
Acox2 GeneProduct ncbigene:93732
Acox3 GeneProduct ncbigene:80911
Ehhadh GeneProduct ncbigene:74147
Acaa1a GeneProduct ncbigene:113868
Ggt1 GeneProduct ncbigene:14598
Ggt5 GeneProduct ncbigene:23887
Dpep1 GeneProduct ncbigene:13479
Dpep2 GeneProduct ncbigene:319446
Ptgr1 GeneProduct ncbigene:67103
Ptgr2 GeneProduct ncbigene:77219
Alox12 GeneProduct ncbigene:11684
Alox5 GeneProduct ncbigene:11689
Ptgr1 GeneProduct ncbigene:67103
Ptgr2 GeneProduct ncbigene:77219
Hpgd GeneProduct ncbigene:15446
Alox5 GeneProduct ncbigene:11689
Lta4h GeneProduct ncbigene:16993
Ltc4s GeneProduct ncbigene:17001
BLT1 Protein uniprot:O88855
MBD Protein eccode:3.4.13.19
8/15-LOX Protein uniprot:O35936
GGT Protein eccode:2.3.2.2
BLT2 Protein uniprot:Q9JJL9
PPAR alpha Protein uniprot:P23204
CYSLT1 Protein uniprot:Q99JA4
CYSLT2 Protein uniprot:Q920A1
ALX Protein uniprot:O88536
8/15-LOX Protein uniprot:O35936
12/15-LOX Protein uniprot:P39654
12/15-LOX Protein uniprot:P39654
12-LOX Protein uniprot:P39655
12(R)-LOX Protein uniprot:P39655
PPAR alpha Protein uniprot:P23204
PPAR beta Protein uniprot:P35396
TRPA1 Protein uniprot:Q8BLA8
TRPV1 Protein uniprot:Q704Y3
5-LOX Protein uniprot:P48999
5-LOX Protein uniprot:P48999
15-LOX Protein uniprot:P39654
12-LOX Protein uniprot:P39655
15-LOX Protein uniprot:P39654
8/15-LOX Protein uniprot:O35936
12/15-LOX Protein uniprot:P39654
12-LOX Protein uniprot:P39655
12(R)-LOX Protein uniprot:P39655

References

  1. Moreno JJ. New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development. Biochem Pharmacol. 2009 Jan 1;77(1):1–10. PubMed Europe PMC Scholia
  2. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. A mouse macrophage lipidome. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia
  3. Dennis EA, Norris PC. Eicosanoid storm in infection and inflammation. Nat Rev Immunol. 2015 Aug;15(8):511–23. PubMed Europe PMC Scholia