Eicosanoid metabolism via cytochrome P450 monooxygenases (WP4349)

This pathway is inspired by the LIPID MAPS>Eicosanoids Pathway expended pathway display [https://lipidmaps.org/pathway/pathways_maps] and extended with the bottom left side of Figure 1 from Dennis and Norris (2015 [https://www.ncbi.nlm.nih.gov/pubmed/26139350]). Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX)[https://www.wikipathways.org/index.php/Pathway:WP4347], lipooxygenases(LOX)[https://www.wikipathways.org/index.php/Pathway:WP4348], or cytochrome P450 monooxygenases (CYP)[https://www.wikipathways.org/index.php/Pathway:WP4349]. This pathway visualises the third route, via CYP. Orange boxes represent peroxisome-proliferator activating receptors (PPARs) potentially activated by the eicosanoids.
last edited

Authors

Eoin Fahy , Ryan Miller , Denise Slenter , Egon Willighagen , and Eric Weitz

Cited In

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Organism

Mus musculus

Communities

Lipids and LIPID MAPS

Annotations

Pathway Ontology: eicosanoid metabolic pathway eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma cytochrome P450 monooxygenase mediated pathway of arachidonic acid metabolism

Participants

Label Type Compact Identifier
Arachidonic acid Metabolite lipidmaps:LMFA01030001
16-HETE Metabolite lipidmaps:LMFA03090010
17-HETE Metabolite lipidmaps:LMFA03060091
18-HETE Metabolite lipidmaps:LMFA03060092
19-HETE Metabolite lipidmaps:LMFA03060106
20-HETE Metabolite lipidmaps:LMFA03060009
5,6-EpETrE Metabolite lipidmaps:LMFA03080002
8,9-EpETrE Metabolite lipidmaps:LMFA03080003
11,12-EpETrE Metabolite lipidmaps:LMFA03090010
14,15-EpETrE Metabolite lipidmaps:LMFA03080005
5,6-DiHETrE Metabolite lipidmaps:LMFA03050004
8,9-DiHETrE Metabolite lipidmaps:LMFA03050006
11,12-DiHETrE Metabolite lipidmaps:LMFA03050008
14,15-DiHETrE Metabolite lipidmaps:LMFA03050010
Ephx2 GeneProduct ncbigene:13850
Cyp4a10 GeneProduct ncbigene:13117
Cyp4a12a GeneProduct ncbigene:277753
Cyp4a12b GeneProduct ncbigene:13118
Cyp4f14 GeneProduct ncbigene:64385
Cyp4f18 GeneProduct ncbigene:72054
PPAR gamma Protein uniprot:P37238
Cyp2c29 Protein ncbigene:13095
Cyp2c37 Protein ncbigene:13096
Cyp2c38 Protein ncbigene:13097
Cyp2c39 Protein ncbigene:13098
Cyp2c40 Protein ncbigene:13099
Cyp2c44 Protein ncbigene:226143
Cyp2c54 Protein ncbigene:404195
Cyp2c55 Protein ncbigene:72082
Cyp2j5 Protein ncbigene:13109
PPAR alpha Protein uniprot:P23204

References

  1. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. A mouse macrophage lipidome. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia
  2. Dennis EA, Norris PC. Eicosanoid storm in infection and inflammation. Nat Rev Immunol. 2015 Aug;15(8):511–23. PubMed Europe PMC Scholia