This pathway is inspired by the LIPID MAPS>Eicosanoids Pathway expended pathway display [https://lipidmaps.org/pathway/pathways_maps] and extended with the bottom left side of Figure 1 from Dennis and Norris (2015 [https://www.ncbi.nlm.nih.gov/pubmed/26139350]). Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX)[https://www.wikipathways.org/index.php/Pathway:WP4347], lipooxygenases(LOX)[https://www.wikipathways.org/index.php/Pathway:WP4348], or cytochrome P450 monooxygenases (CYP)[https://www.wikipathways.org/index.php/Pathway:WP4349]. This pathway visualises the third route, via CYP. Orange boxes represent peroxisome-proliferator activating receptors (PPARs) potentially activated by the eicosanoids.

Authors

Eoin Fahy , Ryan Miller , Denise Slenter , Egon Willighagen , and Eric Weitz

Cited In

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Organism

Mus musculus

Communities

Lipids and LIPID MAPS

Annotations

Pathway Ontology: eicosanoid metabolic pathway eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma cytochrome P450 monooxygenase mediated pathway of arachidonic acid metabolism

Participants

Label	Type	Compact Identifier
Arachidonic acid	Metabolite	lipidmaps:LMFA01030001
16-HETE	Metabolite	lipidmaps:LMFA03090010
17-HETE	Metabolite	lipidmaps:LMFA03060091
18-HETE	Metabolite	lipidmaps:LMFA03060092
19-HETE	Metabolite	lipidmaps:LMFA03060106
20-HETE	Metabolite	lipidmaps:LMFA03060009
5,6-EpETrE	Metabolite	lipidmaps:LMFA03080002
8,9-EpETrE	Metabolite	lipidmaps:LMFA03080003
11,12-EpETrE	Metabolite	lipidmaps:LMFA03090010
14,15-EpETrE	Metabolite	lipidmaps:LMFA03080005
5,6-DiHETrE	Metabolite	lipidmaps:LMFA03050004
8,9-DiHETrE	Metabolite	lipidmaps:LMFA03050006
11,12-DiHETrE	Metabolite	lipidmaps:LMFA03050008
14,15-DiHETrE	Metabolite	lipidmaps:LMFA03050010
Ephx2	GeneProduct	ncbigene:13850
Cyp4a10	GeneProduct	ncbigene:13117
Cyp4a12a	GeneProduct	ncbigene:277753
Cyp4a12b	GeneProduct	ncbigene:13118
Cyp4f14	GeneProduct	ncbigene:64385
Cyp4f18	GeneProduct	ncbigene:72054
PPAR gamma	Protein	uniprot:P37238
Cyp2c29	Protein	ncbigene:13095
Cyp2c37	Protein	ncbigene:13096
Cyp2c38	Protein	ncbigene:13097
Cyp2c39	Protein	ncbigene:13098
Cyp2c40	Protein	ncbigene:13099
Cyp2c44	Protein	ncbigene:226143
Cyp2c54	Protein	ncbigene:404195
Cyp2c55	Protein	ncbigene:72082
Cyp2j5	Protein	ncbigene:13109
PPAR alpha	Protein	uniprot:P23204

References

1. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. A mouse macrophage lipidome. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia
2. Dennis EA, Norris PC. Eicosanoid storm in infection and inflammation. Nat Rev Immunol. 2015 Aug;15(8):511–23. PubMed Europe PMC Scholia