Omega-3 / omega-6 fatty acid synthesis (WP4350)

This pathway is inspired by the Lipidmaps>Omega-3 and omega-6 fatty acids) [https://lipidmaps.org/pathway/pathways_maps]. Omega-3 and omega-6 FAs (Fatty acids) are important fats obtained from diet, and are both polyunsaturated (indicating many double bonds in the lipid tail).The position of the double bond is given in the name of the lipid, for example 22:2(13Z,16Z) means a tail length of 22 carbons, with 2 double bond. One double bond is at the 13 Carbon, the second on the 16th.This number is counted from the tail end of the lipid chain (indicating that the example lipid is a 22 - 16 = omega-6 FA).
last edited

Authors

Eoin Fahy , Ryan Miller , Denise Slenter , Egon Willighagen , Eric Weitz , and Conroy lipids

Cited In

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Organism

Mus musculus

Communities

Lipids and LIPID MAPS

Annotations

Pathway Ontology: fatty acid omega degradation pathway fatty acid elongation pathway unsaturated fatty acid biosynthetic pathway fatty acid metabolic pathway

Participants

Label Type Compact Identifier
Glycerophospholipids Metabolite chebi:37739
Arachidonic acid Metabolite lipidmaps:LMFA01030001
Linoleic acid Metabolite lipidmaps:LMFA01030120
CoA(18:2(9Z,12Z)) Metabolite lipidmaps:LMFA07050343
CoA(18:3(6Z,9Z,12Z)) Metabolite lipidmaps:LMFA07050322
CoA(20:2(11Z,14Z)) Metabolite lipidmaps:LMFA07050036
CoA(20:3(8Z,11Z,14Z)) Metabolite lipidmaps:LMFA07050278
Arachidonoyl-CoA Metabolite lipidmaps:LMFA07050288
gamma-Linolenic acid Metabolite lipidmaps:LMFA01030141
CoA(22:4) Metabolite lipidmaps:LMFA07050129
CoA(24:4) Metabolite lipidmaps:LMFA07050139
20:2(11Z,14Z) Metabolite lipidmaps:LMFA01031043
Bishomo-gamma-linolenic acid Metabolite lipidmaps:LMFA01030158
CoA(22:5(4Z,7Z,10Z,13Z,16Z)) Metabolite lipidmaps:LMFA07050043
alpha-Linolenic acid Metabolite lipidmaps:LMFA01030152
CoA(18:3(9Z,12Z,15Z)) Metabolite lipidmaps:LMFA07050286
CoA(18:4(6Z,9Z,12Z,15Z)) Metabolite lipidmaps:LMFA07050123
CoA(20:4(8Z,11Z,14Z,17Z)) Metabolite lipidmaps:LMFA07050134
CoA(20:5) Metabolite lipidmaps:LMFA07050122
CoA(22:5(7Z,10Z,13Z,16Z,19Z)) Metabolite lipidmaps:LMFA07050131
CoA(22:6) Metabolite lipidmaps:LMFA07050121
CoA(24:5(9Z,12Z,15Z,18Z,21Z)) Metabolite lipidmaps:LMFA07050141
CoA(24:6) Metabolite lipidmaps:LMFA07050127
DHA Metabolite lipidmaps:LMFA01030185
24:6(6Z,9Z,12Z,15Z,18Z,21Z) Metabolite lipidmaps:LMFA01030822
24:5(9Z,12Z,15Z,18Z,21Z) Metabolite lipidmaps:LMFA01030821
22:5(7Z,10Z,13Z,16Z,19Z) Metabolite lipidmaps:LMFA04000044
20:5(5Z,8Z,11Z,14Z,17Z) Metabolite lipidmaps:LMFA01030759
20:4(8Z,11Z,14Z,17Z) Metabolite lipidmaps:LMFA01030818
Stearidonic acid Metabolite lipidmaps:LMFA01030357
22:5(4Z,7Z,10Z,13Z,16Z) Metabolite lipidmaps:LMFA04000064
22:4(7Z,10Z,13Z,16Z) Metabolite lipidmaps:LMFA01030178
24:4(9Z,12Z,15Z,18Z) Metabolite lipidmaps:LMFA01030819
CoA(22:2(13Z,16Z)) Metabolite lipidmaps:LMFA07050037
22:2(13Z,16Z) Metabolite lipidmaps:LMFA01030405
CoA(20:3(11Z,14Z,17Z)) Metabolite lipidmaps:LMFA07050044
20:3(11Z,14Z,17Z) Metabolite lipidmaps:LMFA01030378
CoA(24:5(6Z,9Z,12Z,15Z,18Z)) Metabolite lipidmaps:LMFA07050042
24:5(6Z,9Z,12Z,15Z,18Z) Metabolite lipidmaps:LMFA01030820
Fads2 GeneProduct ncbigene:56473
Acsl1 GeneProduct ncbigene:14081
Fads2 GeneProduct ncbigene:56473
Acls3 GeneProduct ncbigene:74205
Acls4 GeneProduct ncbigene:50790
Elovl2 GeneProduct ncbigene:54326
Elovl5 GeneProduct ncbigene:68801
Fads1 GeneProduct ncbigene:76267
Acox1 GeneProduct ncbigene:11430
Acox3 GeneProduct ncbigene:80911
Fads1 GeneProduct ncbigene:76267
Acot1 GeneProduct ncbigene:26897
Acot2 GeneProduct ncbigene:171210
Fads2 GeneProduct ncbigene:56473
Elovl2 GeneProduct ncbigene:54326
Elovl5 GeneProduct ncbigene:68801
Acsl1 GeneProduct ncbigene:14081
Acsl3 GeneProduct ncbigene:74205
Acsl4 GeneProduct ncbigene:50790
Fads2 GeneProduct ncbigene:56473
Acox1 GeneProduct ncbigene:11430
Acox3 GeneProduct ncbigene:80911
Elovl2 GeneProduct ncbigene:54326
Elovl5 GeneProduct ncbigene:68801
Acot1 GeneProduct ncbigene:26897
Acot2 GeneProduct ncbigene:171210
Pla2g5 Protein ncbigene:18784
Pla2g6 Protein ncbigene:53357
Pla2g4a Protein ncbigene:18783
Pla2g4b Protein ncbigene:211429
Pla2g5 Protein ncbigene:18784
Pla2g6 Protein ncbigene:53357
Pla2g4a Protein ncbigene:18783
Pla2g4b Protein ncbigene:211429

References

  1. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. A mouse macrophage lipidome. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia