Omega-3 / omega-6 fatty acid synthesis (WP4350)
This pathway is inspired by the Lipidmaps>Omega-3 and omega-6 fatty acids) [https://lipidmaps.org/pathway/pathways_maps]. Omega-3 and omega-6 FAs (Fatty acids) are important fats obtained from diet, and are both polyunsaturated (indicating many double bonds in the lipid tail).The position of the double bond is given in the name of the lipid, for example 22:2(13Z,16Z) means a tail length of 22 carbons, with 2 double bond. One double bond is at the 13 Carbon, the second on the 16th.This number is counted from the tail end of the lipid chain (indicating that the example lipid is a 22 - 16 = omega-6 FA).
Authors
Eoin Fahy , Ryan Miller , Denise Slenter , Egon Willighagen , Eric Weitz , and Conroy lipidsCited In
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Organism
Mus musculusCommunities
Lipids and LIPID MAPSAnnotations
Pathway Ontology: fatty acid omega degradation pathway fatty acid elongation pathway unsaturated fatty acid biosynthetic pathway fatty acid metabolic pathway
Participants
| Label | Type | Compact Identifier |
|---|---|---|
| Glycerophospholipids | Metabolite | chebi:37739 |
| Arachidonic acid | Metabolite | lipidmaps:LMFA01030001 |
| Linoleic acid | Metabolite | lipidmaps:LMFA01030120 |
| CoA(18:2(9Z,12Z)) | Metabolite | lipidmaps:LMFA07050343 |
| CoA(18:3(6Z,9Z,12Z)) | Metabolite | lipidmaps:LMFA07050322 |
| CoA(20:2(11Z,14Z)) | Metabolite | lipidmaps:LMFA07050036 |
| CoA(20:3(8Z,11Z,14Z)) | Metabolite | lipidmaps:LMFA07050278 |
| Arachidonoyl-CoA | Metabolite | lipidmaps:LMFA07050288 |
| gamma-Linolenic acid | Metabolite | lipidmaps:LMFA01030141 |
| CoA(22:4) | Metabolite | lipidmaps:LMFA07050129 |
| CoA(24:4) | Metabolite | lipidmaps:LMFA07050139 |
| 20:2(11Z,14Z) | Metabolite | lipidmaps:LMFA01031043 |
| Bishomo-gamma-linolenic acid | Metabolite | lipidmaps:LMFA01030158 |
| CoA(22:5(4Z,7Z,10Z,13Z,16Z)) | Metabolite | lipidmaps:LMFA07050043 |
| alpha-Linolenic acid | Metabolite | lipidmaps:LMFA01030152 |
| CoA(18:3(9Z,12Z,15Z)) | Metabolite | lipidmaps:LMFA07050286 |
| CoA(18:4(6Z,9Z,12Z,15Z)) | Metabolite | lipidmaps:LMFA07050123 |
| CoA(20:4(8Z,11Z,14Z,17Z)) | Metabolite | lipidmaps:LMFA07050134 |
| CoA(20:5) | Metabolite | lipidmaps:LMFA07050122 |
| CoA(22:5(7Z,10Z,13Z,16Z,19Z)) | Metabolite | lipidmaps:LMFA07050131 |
| CoA(22:6) | Metabolite | lipidmaps:LMFA07050121 |
| CoA(24:5(9Z,12Z,15Z,18Z,21Z)) | Metabolite | lipidmaps:LMFA07050141 |
| CoA(24:6) | Metabolite | lipidmaps:LMFA07050127 |
| DHA | Metabolite | lipidmaps:LMFA01030185 |
| 24:6(6Z,9Z,12Z,15Z,18Z,21Z) | Metabolite | lipidmaps:LMFA01030822 |
| 24:5(9Z,12Z,15Z,18Z,21Z) | Metabolite | lipidmaps:LMFA01030821 |
| 22:5(7Z,10Z,13Z,16Z,19Z) | Metabolite | lipidmaps:LMFA04000044 |
| 20:5(5Z,8Z,11Z,14Z,17Z) | Metabolite | lipidmaps:LMFA01030759 |
| 20:4(8Z,11Z,14Z,17Z) | Metabolite | lipidmaps:LMFA01030818 |
| Stearidonic acid | Metabolite | lipidmaps:LMFA01030357 |
| 22:5(4Z,7Z,10Z,13Z,16Z) | Metabolite | lipidmaps:LMFA04000064 |
| 22:4(7Z,10Z,13Z,16Z) | Metabolite | lipidmaps:LMFA01030178 |
| 24:4(9Z,12Z,15Z,18Z) | Metabolite | lipidmaps:LMFA01030819 |
| CoA(22:2(13Z,16Z)) | Metabolite | lipidmaps:LMFA07050037 |
| 22:2(13Z,16Z) | Metabolite | lipidmaps:LMFA01030405 |
| CoA(20:3(11Z,14Z,17Z)) | Metabolite | lipidmaps:LMFA07050044 |
| 20:3(11Z,14Z,17Z) | Metabolite | lipidmaps:LMFA01030378 |
| CoA(24:5(6Z,9Z,12Z,15Z,18Z)) | Metabolite | lipidmaps:LMFA07050042 |
| 24:5(6Z,9Z,12Z,15Z,18Z) | Metabolite | lipidmaps:LMFA01030820 |
| Fads2 | GeneProduct | ncbigene:56473 |
| Acsl1 | GeneProduct | ncbigene:14081 |
| Fads2 | GeneProduct | ncbigene:56473 |
| Acls3 | GeneProduct | ncbigene:74205 |
| Acls4 | GeneProduct | ncbigene:50790 |
| Elovl2 | GeneProduct | ncbigene:54326 |
| Elovl5 | GeneProduct | ncbigene:68801 |
| Fads1 | GeneProduct | ncbigene:76267 |
| Acox1 | GeneProduct | ncbigene:11430 |
| Acox3 | GeneProduct | ncbigene:80911 |
| Fads1 | GeneProduct | ncbigene:76267 |
| Acot1 | GeneProduct | ncbigene:26897 |
| Acot2 | GeneProduct | ncbigene:171210 |
| Fads2 | GeneProduct | ncbigene:56473 |
| Elovl2 | GeneProduct | ncbigene:54326 |
| Elovl5 | GeneProduct | ncbigene:68801 |
| Acsl1 | GeneProduct | ncbigene:14081 |
| Acsl3 | GeneProduct | ncbigene:74205 |
| Acsl4 | GeneProduct | ncbigene:50790 |
| Fads2 | GeneProduct | ncbigene:56473 |
| Acox1 | GeneProduct | ncbigene:11430 |
| Acox3 | GeneProduct | ncbigene:80911 |
| Elovl2 | GeneProduct | ncbigene:54326 |
| Elovl5 | GeneProduct | ncbigene:68801 |
| Acot1 | GeneProduct | ncbigene:26897 |
| Acot2 | GeneProduct | ncbigene:171210 |
| Pla2g5 | Protein | ncbigene:18784 |
| Pla2g6 | Protein | ncbigene:53357 |
| Pla2g4a | Protein | ncbigene:18783 |
| Pla2g4b | Protein | ncbigene:211429 |
| Pla2g5 | Protein | ncbigene:18784 |
| Pla2g6 | Protein | ncbigene:53357 |
| Pla2g4a | Protein | ncbigene:18783 |
| Pla2g4b | Protein | ncbigene:211429 |
References
- Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. A mouse macrophage lipidome. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia