Omega-9 fatty acid synthesis (WP4351)
This pathway is inspired by the Lipidmaps>Omega-9 and other fatty acids [https://lipidmaps.org/pathway/pathways_maps]. Omega-9 FAs (Fatty acids) are fats which can be obtained from diet, but also produced endogenously. These lipids are monounsaturated (indicating one double bonds in the lipid tail).The position of the double bond is counted from the tail end of the lipid chain. This pathway also indicated saturated fats (without a double bond), such as stearic acid, arachidic acid etc.
Authors
Eoin Fahy , Ryan Miller , Denise Slenter , Eric Weitz , Egon Willighagen , and Conroy lipidsCited In
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Organism
Mus musculusCommunities
Lipids and LIPID MAPSAnnotations
Pathway Ontology: fatty acid metabolic pathway unsaturated fatty acid biosynthetic pathway fatty acid elongation pathway
Participants
| Label | Type | Compact Identifier |
|---|---|---|
| CoA(20:0) | Metabolite | lipidmaps:LMFA07050329 |
| Lauric acid | Metabolite | lipidmaps:LMFA01010012 |
| Myristic acid | Metabolite | lipidmaps:LMFA01010014 |
| CoA(16:0) | Metabolite | lipidmaps:LMFA07050360 |
| CoA(16:1(9Z)) | Metabolite | lipidmaps:LMFA07050359 |
| CoA(18:1(9Z)) | Metabolite | lipidmaps:LMFA07050356 |
| CoA(18:2(6Z,9Z)) | Metabolite | lipidmaps:LMFA07050060 |
| CoA(20:1(11Z)) | Metabolite | lipidmaps:LMFA07050093 |
| CoA(20:2(8Z,11Z)) | Metabolite | lipidmaps:LMFA07050061 |
| 18:2(6Z,9Z) | Metabolite | lipidmaps:LMFA07050060 |
| Stearic acid | Metabolite | lipidmaps:LMFA01010018 |
| 16:1(9Z) | Metabolite | lipidmaps:LMFA01030056 |
| CoA(18:0) | Metabolite | lipidmaps:LMFA07050369 |
| Palmitic acid | Metabolite | lipidmaps:LMFA01010001 |
| CoA(22:0) | Metabolite | lipidmaps:LMFA07050289 |
| CoA(24:0) | Metabolite | lipidmaps:LMFA07050372 |
| CoA(26:0) | Metabolite | lipidmaps:LMFA07050327 |
| Arachidic acid | Metabolite | lipidmaps:LMFA01010020 |
| Behenic acid | Metabolite | lipidmaps:LMFA01010022 |
| Lignoceric acid | Metabolite | lipidmaps:LMFA01010024 |
| Cerotic acid | Metabolite | lipidmaps:LMFA01010026 |
| CoA(22:1(13Z)) | Metabolite | lipidmaps:LMFA07050318 |
| CoA(24:1(15Z)) | Metabolite | lipidmaps:LMFA07050098 |
| 20:2(8Z,11Z) | Metabolite | lipidmaps:LMFA01030377 |
| CoA(20:3(5Z,8Z,11Z)) | Metabolite | lipidmaps:LMFA07050062 |
| 20:3(5Z,8Z,11Z) | Metabolite | lipidmaps:LMFA01030381 |
| Oleic acid | Metabolite | lipidmaps:LMFA01030002 |
| 24:1(15Z)) | Metabolite | lipidmaps:LMFA01030377 |
| cis-erucic acid | Metabolite | cas:112-86-7 |
| Fads1 | GeneProduct | ncbigene:76267 |
| Acsl1 | GeneProduct | ncbigene:14081 |
| Fasn | GeneProduct | ncbigene:14104 |
| Acsl3 | GeneProduct | ncbigene:74205 |
| Acsl4 | GeneProduct | ncbigene:50790 |
| Elovl2 | GeneProduct | ncbigene:54326 |
| Elovl5 | GeneProduct | ncbigene:68801 |
| Elovl6 | GeneProduct | ncbigene:170439 |
| Elovl3 | GeneProduct | ncbigene:12686 |
| Elovl1 | GeneProduct | ncbigene:54325 |
| Scd2 | GeneProduct | ncbigene:20250 |
| Fads2 | GeneProduct | ncbigene:56473 |
| Acot1 | GeneProduct | ncbigene:26897 |
| Acot2 | GeneProduct | ncbigene:171210 |
| Acot1 | GeneProduct | ncbigene:26897 |
References
- Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. A mouse macrophage lipidome. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia